{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T02:00:55Z","timestamp":1793152855161,"version":"4.5.0"},"reference-count":31,"publisher":"American Academy of Pediatrics (AAP)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,1,1]]},"abstract":"<jats:sec>\n                  <jats:title\/>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONTEXT:<\/jats:title>\n                  <jats:p>The International Liaison Committee on Resuscitation prioritized to rigorously review the initial fraction of inspired oxygen (Fio2) during resuscitation of newborns.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>OBJECTIVE:<\/jats:title>\n                  <jats:p>This systematic review and meta-analysis provides the scientific summary of initial Fio2 in term and late preterm newborns (\u226535 weeks\u2019 gestation) who receive respiratory support at birth.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>DATA SOURCES:<\/jats:title>\n                  <jats:p>Medline, Embase, Evidence Based Medicine Reviews, and Cumulative Index to Nursing and Allied Health Literature were searched between January 1, 1980 and August 10, 2018.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>STUDY SELECTION:<\/jats:title>\n                  <jats:p>Studies were selected by pairs of independent reviewers in 2 stages, with a Cohen\u2019s \u03ba of 0.8 and 1.0.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>DATA EXTRACTION:<\/jats:title>\n                  <jats:p>Pairs of independent reviewers extracted data, appraised risk of bias, and assessed Grading of Recommendations Assessment, Development and Evaluation certainty of evidence.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS:<\/jats:title>\n                  <jats:p>Five randomized controlled trials (RCTs) and 5 quasi RCTs included 2164 patients. Room air (Fio2 0.21) was associated with a statistically significant benefit in short-term mortality compared with 100% oxygen (Fio2 1.0) (7 RCTs; n = 1469; risk ratio [RR] = 0.73; 95% confidence interval [CI]: 0.57 to 0.94). No significant differences were observed in neurodevelopmental impairment (2 RCTs; n = 360; RR = 1.41; 95% CI: 0.77 to 2.60) or hypoxic-ischemic encephalopathy (5 RCTs; n = 1315; RR = 0.89; 95% CI: 0.68 to 1.18).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>LIMITATIONS:<\/jats:title>\n                  <jats:p>The Grading of Recommendations Assessment, Development and Evaluation certainty of evidence was low for short-term mortality and hypoxic-ischemic encephalopathy and very low for neurodevelopmental impairment.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS:<\/jats:title>\n                  <jats:p>Room air has a 27% relative reduction in short-term mortality compared with Fio2 1.0 for initiating neonatal resuscitation \u226535 weeks\u2019 gestation.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1542\/peds.2018-1825","type":"journal-article","created":{"date-parts":[[2018,12,21]],"date-time":"2018-12-21T13:46:27Z","timestamp":1545399987000},"source":"Crossref","is-referenced-by-count":59,"title":["Room Air for Initiating Term Newborn Resuscitation: A Systematic Review With Meta-analysis"],"prefix":"10.1542","volume":"143","author":[{"given":"Michelle","family":"Welsford","sequence":"first","affiliation":[{"name":"Division of Emergency Medicine, McMaster University, Hamilton, Ontario, Canada;"},{"name":"Hamilton Health Sciences, Centre for Paramedic Education and Research, Hamilton, Ontario, Canada;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chika","family":"Nishiyama","sequence":"additional","affiliation":[{"name":"Department of Critical Care Nursing, Graduate School of Human Health Science, Kyoto University, Kyoto, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colleen","family":"Shortt","sequence":"additional","affiliation":[{"name":"Hamilton Health Sciences, Centre for Paramedic Education and Research, Hamilton, Ontario, Canada;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuya","family":"Isayama","sequence":"additional","affiliation":[{"name":"Division of Neonatalogy, National Center for Child Health and Development, Tokyo, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer Anne","family":"Dawson","sequence":"additional","affiliation":[{"name":"Neonatal Services, The Royal Women\u2019s Hospital and University of Melbourne, Melbourne, Australia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary","family":"Weiner","sequence":"additional","affiliation":[{"name":"Pediatrics and Communicable Diseases, University of Michigan and C. 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Mott Children\u2019s Hospital, Ann Arbor, Michigan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles Christoph","family":"Roehr","sequence":"additional","affiliation":[{"name":"Medical Sciences Division, Department of Paediatrics, University of Oxford, Oxford, United Kingdom;"},{"name":"Newborn Services, John Radcliffe Hospital, Oxford University Hospitals, National Health Service Foundation Trust, Oxford, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myra H.","family":"Wyckoff","sequence":"additional","affiliation":[{"name":"Division of Neonatal-Perinatal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yacov","family":"Rabi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Calgary, Calgary, Alberta, Canada; and"},{"name":"Alberta Children\u2019s Hospital Research Institute, Calgary, Alberta, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"on behalf of the International Liaison Committee on Resuscitation Neonatal Life Support Task Force","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"417","published-online":{"date-parts":[[2019,1,1]]},"reference":[{"issue":"3","key":"2021121012445933800_B1","article-title":"International guidelines for neonatal resuscitation: an excerpt from the guidelines 2000 for cardiopulmonary resuscitation and emergency cardiovascular care: international consensus on science. 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