{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T22:40:59Z","timestamp":1793572859126,"version":"4.5.0"},"reference-count":54,"publisher":"American Academy of Pediatrics (AAP)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,12,1]]},"abstract":"<jats:sec>\n                    <jats:title>OBJECTIVES:<\/jats:title>\n                    <jats:p>Adult obesity is linked to asthma cases and is estimated to lead to 250\u2009000 new cases yearly. Similar incidence and attributable risk (AR) estimates have not been developed for children. We sought to describe the relationship between overweight and obesity and incident asthma in childhood and quantify AR statistics in the United States for overweight and obesity on pediatric asthma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>The PEDSnet clinical data research network was used to conduct a retrospective cohort study (January 2009\u2013December 2015) to compare asthma incidence among overweight and\/or obese versus healthy weight 2- to 17-year-old children. Asthma incidence was defined as \u22652 encounters with a diagnosis of asthma and \u22651 asthma controller prescription. Stricter diagnostic criteria involved confirmation by spirometry. We used multivariable Poisson regression analyses to estimate incident asthma rates and risk ratios and accepted formulas for ARs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>Data from 507\u2009496 children and 19\u2009581\u2009972 encounters were included. The mean participant observation period was 4 years. The adjusted risk for incident asthma was increased among children who were overweight (relative risk [RR]: 1.17; 95% confidence interval [CI]: 1.10\u20131.25) and obese (RR: 1.26; 95% CI: 1.18\u20131.34). The adjusted risk for spirometry-confirmed asthma was increased among children with obesity (RR: 1.29; 95% CI: 1.16\u20131.42). An estimated 23% to 27% of new asthma cases in children with obesity is directly attributable to obesity. In the absence of overweight and obesity, 10% of all cases of asthma would be avoided.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>Obesity is a major preventable risk factor for pediatric asthma.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1542\/peds.2018-2119","type":"journal-article","created":{"date-parts":[[2018,11,26]],"date-time":"2018-11-26T08:25:13Z","timestamp":1543220713000},"source":"Crossref","is-referenced-by-count":141,"title":["Being Overweight or Obese and the Development of Asthma"],"prefix":"10.1542","volume":"142","author":[{"given":"Jason E.","family":"Lang","sequence":"first","affiliation":[{"name":"Nemours Children\u2019s Hospital, Nemours Children\u2019s Health System, Orlando, Florida;"},{"name":"Divisions of Allergy and Immunology and"},{"name":"Pulmonary Medicine, School of Medicine, Duke University and Duke Children\u2019s Hospital and Health Center, Durham, North Carolina;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. Timothy","family":"Bunnell","sequence":"additional","affiliation":[{"name":"Department of Biomedical Research, Nemours Alfred I. DuPont Hospital for Children, Wilmington, Delaware;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md Jobayer","family":"Hossain","sequence":"additional","affiliation":[{"name":"Department of Biomedical Research, Nemours Alfred I. DuPont Hospital for Children, Wilmington, Delaware;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim","family":"Wysocki","sequence":"additional","affiliation":[{"name":"Centers for Health Care Delivery Science and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John J.","family":"Lima","sequence":"additional","affiliation":[{"name":"Pharmacogenomics and Translational Research, Nemours Children\u2019s Health System, Jacksonville, Florida;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terri H.","family":"Finkel","sequence":"additional","affiliation":[{"name":"Nemours Children\u2019s Hospital, Nemours Children\u2019s Health System, Orlando, Florida;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonard","family":"Bacharier","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Washington University, St Louis, 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An 8-year update.","volume":"189","author":"Rosser","year":"2014","journal-title":"Am J Respir Crit Care Med"},{"issue":"4","key":"2021121020542922400_B50","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1016\/j.jaci.2017.09.043","article-title":"Overweight\/obesity status in preschool children associates with worse asthma but robust improvement on inhaled corticosteroids.","volume":"141","author":"Lang","year":"2018","journal-title":"J Allergy Clin Immunol"},{"issue":"4","key":"2021121020542922400_B51","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1016\/j.jaci.2014.08.029","article-title":"Overweight children report qualitatively distinct asthma symptoms: analysis of validated symptom measures.","volume":"135","author":"Lang","year":"2015","journal-title":"J Allergy Clin Immunol"},{"issue":"5","key":"2021121020542922400_B52","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1016\/j.jaci.2011.06.031","article-title":"The association of obesity and asthma severity and control in children.","volume":"128","author":"Quinto","year":"2011","journal-title":"J Allergy Clin Immunol"},{"issue":"23","key":"2021121020542922400_B53","doi-asserted-by":"crossref","first-page":"2410","DOI":"10.1001\/jama.2018.5158","article-title":"Differences in obesity prevalence by demographics and urbanization in US children and adolescents, 2013-2016.","volume":"319","author":"Ogden","year":"2018","journal-title":"JAMA"},{"key":"2021121020542922400_B54","unstructured":"Lang\u2008JE, Bunnell\u2008T, Hossain\u2008MJ, et al. Demonstrating the value of PEDSnet EHR-generated data: defining key determinants on the path from obesity to asthma in children (KOACH). 2017. Available at: https:\/\/pedsnet.org\/research\/pedsnet-studies-active\/demonstrating-value-pedsnet-ehr-generated-data-defining-key-determinants-path-obesity-asthma-children-koach\/. Accessed November 14, 2017"}],"container-title":["Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/publications.aap.org\/pediatrics\/article-pdf\/doi\/10.1542\/peds.2018-2119\/1075691\/peds_20182119.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/publications.aap.org\/pediatrics\/article-pdf\/doi\/10.1542\/peds.2018-2119\/1075691\/peds_20182119.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,11]],"date-time":"2021-12-11T01:42:37Z","timestamp":1639186957000},"score":1,"resource":{"primary":{"URL":"https:\/\/publications.aap.org\/pediatrics\/article\/142\/6\/e20182119\/37481\/Being-Overweight-or-Obese-and-the-Development-of"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12,1]]},"references-count":54,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2018,12,1]]},"published-print":{"date-parts":[[2018,12,1]]}},"URL":"https:\/\/doi.org\/10.1542\/peds.2018-2119","relation":{},"ISSN":["0031-4005","1098-4275"],"issn-type":[{"value":"0031-4005","type":"print"},{"value":"1098-4275","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,12,1]]},"article-number":"e20182119"}}