{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,5]],"date-time":"2025-08-05T13:03:28Z","timestamp":1754399008963,"version":"3.41.2"},"reference-count":42,"publisher":"American Academy of Pediatrics (AAP)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,4,1]]},"abstract":"<jats:p>ABO blood group incompatibility between mother and fetus can lead to hemolytic disease of the fetus and newborn (HDFN). We present the first case of severe O\/A HDFN associated with extremely high-titer (1:32\u2009000) immunoglobulin G anti-A antibodies in a Cameroon mother. Cord blood analysis revealed severe fetal hemolytic anemia and conjugated hyperbilirubinemia. After exclusion of an underlying disease and other risk factors, cholestasis resolved after treatment with ursodeoxycholic acid, a red blood cell transfusion, and intravenous immunoglobulins. This case is presented to create awareness for a more severe course of ABO HDFN in nonwhite and non-European mother-child pairs.<\/jats:p>","DOI":"10.1542\/peds.2018-2859","type":"journal-article","created":{"date-parts":[[2019,3,14]],"date-time":"2019-03-14T12:25:20Z","timestamp":1552566320000},"source":"Crossref","is-referenced-by-count":14,"title":["Severe Fetal Hemolysis and Cholestasis Due to High-Titer Maternal IgG Anti-A Antibodies"],"prefix":"10.1542","volume":"143","author":[{"given":"Rens","family":"Zonneveld","sequence":"first","affiliation":[{"name":"Department of Pediatrics and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"van der Meer-Kapelle","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc","family":"Sylva","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Sophia Children\u2019s Hospital, Erasmus Medical Center, 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