{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T06:21:27Z","timestamp":1792131687829,"version":"4.4.0"},"reference-count":22,"publisher":"American Academy of Pediatrics (AAP)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,10,1]]},"abstract":"\n \n <\/jats:sec>\n \n BACKGROUND:<\/jats:title>\n Newborn screening provides early diagnosis for children with sickle cell disease (SCD), reducing disease-related mortality. We hypothesized that rapid point-of-care (POC) Sickle SCAN would be reliable in Haiti and would assist newborn screening.<\/jats:p>\n <\/jats:sec>\n \n METHODS:<\/jats:title>\n Dried blood specimens were obtained from infant heel sticks and analyzed by isoelectric focusing (IEF) at a public hospital in Cap-Ha\u00eftien during a 1-year period. A total of 360 Guthrie cards were also analyzed for quality assurance by high-performance liquid chromatography at the Florida Newborn Screening Laboratory. In addition, two-thirds of the infants were also screened by the POC to assess differences with the IEF. The hemoglobinopathy incidence and the specificity and sensitivity of the POC scan were assessed.<\/jats:p>\n <\/jats:sec>\n \n RESULTS:<\/jats:title>\n Overall, 1.48% of the children screened positive for SCD. The specificity and the sensitivity of POC Sickle SCAN were 0.97 (confidence interval 0.95\u20130.99) and 0.90 (confidence interval 0.55\u20131.00), respectively, relative to high-performance liquid chromatography gold standard. The confirmatory testing rate was 75% before POC and improved to 87% after POC was added for dual screening. Confirmatory testing revealed that 0.83% of children screened had SCD. Children who screened positive for SCD by POC started penicillin earlier, had their first pediatric follow-up a median of 38 days earlier, and received antipneumococcal vaccination on time when compared with those who screened positive for SCD by IEF alone.<\/jats:p>\n <\/jats:sec>\n \n CONCLUSIONS:<\/jats:title>\n The observational study revealed a high incidence of SCD among Haitian newborns. Sickle SCAN had excellent specificity and sensitivity to detect SCD during newborn screening and shortened health care access for children positive for SCD.<\/jats:p>\n <\/jats:sec>","DOI":"10.1542\/peds.2018-4105","type":"journal-article","created":{"date-parts":[[2019,9,17]],"date-time":"2019-09-17T08:25:12Z","timestamp":1568708712000},"source":"Crossref","is-referenced-by-count":40,"title":["Newborn Screening for Sickle Cell Disease Using Point-of-Care Testing in Low-Income Setting"],"prefix":"10.1542","volume":"144","author":[{"given":"Ofelia A.","family":"Alvarez","sequence":"first","affiliation":[{"name":"aDivision of Pediatric Hematology, Department of Pediatrics, and"},{"name":"cH\u00f4pital Universitaire Justinien, Cap-Ha\u00eftien, Haiti"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tally","family":"Hustace","sequence":"additional","affiliation":[{"name":"aDivision of Pediatric Hematology, Department of Pediatrics, and"},{"name":"cH\u00f4pital Universitaire Justinien, Cap-Ha\u00eftien, Haiti"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mimose","family":"Voltaire","sequence":"additional","affiliation":[{"name":"cH\u00f4pital Universitaire Justinien, Cap-Ha\u00eftien, Haiti"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro","family":"Mantero","sequence":"additional","affiliation":[{"name":"bDepartment of Public Health, University of Miami, Miami, Florida; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrick","family":"Liberus","sequence":"additional","affiliation":[{"name":"cH\u00f4pital Universitaire Justinien, Cap-Ha\u00eftien, Haiti"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rony","family":"Saint Fleur","sequence":"additional","affiliation":[{"name":"cH\u00f4pital Universitaire Justinien, Cap-Ha\u00eftien, Haiti"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"417","published-online":{"date-parts":[[2019,10,1]]},"reference":[{"issue":"9","key":"2025062311020194100_B1","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1001\/jama.1987.03400090089040","article-title":"Consensus conference. Newborn screening for sickle cell disease and other hemoglobinopathies","volume":"258","year":"1987","journal-title":"JAMA"},{"issue":"7","key":"2025062311020194100_B2","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1097\/DBP.0b013e3181eedf01","article-title":"An overview of newborn screening","volume":"31","author":"Levy","year":"2010","journal-title":"J Dev Behav Pediatr"},{"key":"2025062311020194100_B3","unstructured":"National Institutes of Health\n . Uniform sceening panel. Available at: https:\/\/www.hrsa.gov\/advisory-committees\/heritable-disorders\/index.html. Accessed November 22, 2018"},{"key":"2025062311020194100_B4","volume-title":"L\u2019An\u00e9mie Falciforme. Trait\u00e9 \u00c0 L\u2019Usage Des G\u00e9n\u00e9ralistes et Des \u00c9tudiants En Sciences de La Sant\u00e9 D\u2019 Ha\u00efti","author":"Fleurival","year":"2015"},{"key":"2025062311020194100_B5","unstructured":"World Population Review. Haiti population 2019. Available at: http:\/\/worldpopulationreview.com\/countries\/haiti-population\/. Accessed February 27, 2019"},{"key":"2025062311020194100_B6","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1186\/s12916-015-0473-6","article-title":"Validation of a novel point of care testing device for sickle cell disease","volume":"13","author":"Kanter","year":"2015","journal-title":"BMC Med"},{"issue":"4","key":"2025062311020194100_B7","first-page":"416","article-title":"Sickle SCANTM (BioMedomics) fulfills analytical conditions for neonatal screening of sickle cell disease","volume":"76","author":"Nguyen-Khoa","year":"2018","journal-title":"Ann Biol Clin (Paris)"},{"issue":"5","key":"2025062311020194100_B8","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1182\/blood.V51.5.971.971","article-title":"Isoelectric focusing of human hemoglobin: its application to screening, to the characterization of 70 variants, and to the study of modified fractions of normal hemoglobins","volume":"51","author":"Basset","year":"1978","journal-title":"Blood"},{"issue":"7","key":"2025062311020194100_B9","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1093\/clinchem\/45.7.969","article-title":"Evaluation of cation-exchange HPLC compared with isoelectric focusing for neonatal hemoglobinopathy screening","volume":"45","author":"Campbell","year":"1999","journal-title":"Clin Chem"},{"key":"2025062311020194100_B10","volume-title":"NBS01-A6: Blood Collection on Filter Paper for Newborn Screening Programs; Approved Standards","author":"Clinical and Laboratory Standards Institute","year":"2013","edition":"6th ed"},{"issue":"6943","key":"2025062311020194100_B11","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.1136\/bmj.308.6943.1552","article-title":"Diagnostic tests. 1: sensitivity and specificity","volume":"308","author":"Altman","year":"1994","journal-title":"BMJ"},{"key":"2025062311020194100_B12","volume-title":"UEP12-A2: User Protocol for Evaluation of Qualitative Test Performance; Approved Guideline","author":"Clinical and Laboratory Standards Institute","year":"2008","edition":"2nd Ed"},{"issue":"6","key":"2025062311020194100_B13","doi-asserted-by":"crossref","first-page":"e20182997","DOI":"10.1542\/peds.2018-2997","article-title":"The role of pediatricians in global health","volume":"142","author":"Suchdev","year":"2018","journal-title":"Pediatrics"},{"key":"2025062311020194100_B14","unstructured":"Centers for Disease and Prevention\n . Data & statistics on sickle cell disease. Available at: https:\/\/www.cdc.gov\/ncbddd\/sicklecell\/data.html. 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