{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T22:18:50Z","timestamp":1791497930646,"version":"4.3.4"},"reference-count":58,"publisher":"American Academy of Pediatrics (AAP)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,8,1]]},"abstract":"<jats:sec><jats:title>BACKGROUND AND OBJECTIVES:<\/jats:title><jats:p>Whether BMI captures adiposity and cardiometabolic risk in Down syndrome (DS), a condition associated with obesity, short stature, and altered body proportions, is not known. We compared cardiometabolic risk measures in youth with DS and typically developing matched controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS:<\/jats:title><jats:p>Youth with (n = 150) and without (n = 103) DS of comparable age (10\u201320 years), sex, race, ethnicity, and BMI percentile underwent whole-body dual-energy X-ray absorptiometry, fasting glucose, insulin, lipids, lipoprotein particles, inflammatory factors, and when BMI percentile \u226585, an oral glucose tolerance test.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS:<\/jats:title><jats:p>Sixty-four percent of youth with DS had BMI percentile \u226585. Among these, no difference in glucose, insulin, or insulin resistance was detected, but prediabetes was more prevalent with DS (26.4% vs 10.3%; P = .025) after adjustment for demographics, pubertal status, and BMI z score (odds ratio = 3.2; P = .026). Among all participants, those with DS had higher low-density lipoprotein cholesterol (median 107 [interquartile range 89\u2013128] vs 88.5 [79\u2013103] mg\/dL; P &amp;lt; .00005), triglycerides (89.5 [73\u2013133] vs 71.5 [56\u2013104] mg\/dL; P &amp;lt; .00005), non\u2013high-density lipoprotein cholesterol (non-HDL-C; 128 [104\u2013153] vs 107 [92\u2013123] mg\/dL; P &amp;lt; .00005), and triglycerides\/HDL-C (2.2 [1.6\u20133.4] vs 1.7 [1.1\u20132.5] mg\/dL; P = .0003) and lower levels of HDL-C (41 [36.5\u201347] vs 45 [37\u201353] mg\/dL; P = .012). DS youth had higher high-sensitivity C-reactive protein, interleukin-6, small low-density lipoprotein particles (LDL-P), and total LDL-P, but similar LDL-P size. Youth with DS had less visceral fat (VFAT), fat mass, and lean mass for BMI z score, but greater VFAT at higher fat mass. However, VFAT did not fully explain the increased prevalence of dyslipidemia or prediabetes in youth with DS.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS:<\/jats:title><jats:p>Despite similar insulin resistance, youth with DS had greater prevalence of dyslipidemia and prediabetes than typically developing youth, which was not fully explained by VFAT.<\/jats:p><\/jats:sec>","DOI":"10.1542\/peds.2019-0137","type":"journal-article","created":{"date-parts":[[2019,7,17]],"date-time":"2019-07-17T12:25:12Z","timestamp":1563366312000},"source":"Crossref","is-referenced-by-count":52,"title":["Cardiometabolic Risk and Body Composition in Youth With Down Syndrome"],"prefix":"10.1542","volume":"144","author":[{"given":"Sheela N.","family":"Magge","sequence":"first","affiliation":[{"name":"Division of Endocrinology and Diabetes, School of Medicine and Health Sciences, The George Washington University and Clinical and Translational Science Institute at Children\u2019s National, Children\u2019s Research Institute, Children\u2019s National Health System, Washington, District of Columbia; Divisions of"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Babette S.","family":"Zemel","sequence":"additional","affiliation":[{"name":"Gastroenterology, Hepatology, and Nutrition,"},{"name":"Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary E.","family":"Pipan","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania; and"},{"name":"Developmental Behavioral Pediatrics, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel S.","family":"Gidding","sequence":"additional","affiliation":[{"name":"Familial Hypercholesterolemia Foundation, Pasadena, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Kelly","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania; and"},{"name":"Endocrinology and Diabetes, Children\u2019s Hospital of Philadelphia, Philadelphia, Pennsylvania;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"417","published-online":{"date-parts":[[2019,8,1]]},"reference":[{"issue":"7","key":"2021121018253243200_B1","doi-asserted-by":"crossref","first-page":"M470","DOI":"10.1093\/gerona\/57.7.M470","article-title":"The influence of intellectual disability on life expectancy.","volume":"57","author":"Bittles","year":"2002","journal-title":"J Gerontol A Biol Sci Med Sci"},{"issue":"4","key":"2021121018253243200_B2","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1111\/j.1469-8749.2004.tb00483.x","article-title":"Clinical, social, and ethical implications of changing life expectancy in Down syndrome.","volume":"46","author":"Bittles","year":"2004","journal-title":"Dev Med Child Neurol"},{"issue":"6081","key":"2021121018253243200_B3","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1136\/bmj.2.6081.226","article-title":"Down\u2019s syndrome: an atheroma-free model?","volume":"2","author":"Murdoch","year":"1977","journal-title":"Br Med J"},{"issue":"2\u20133","key":"2021121018253243200_B4","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/0021-9150(89)90110-X","article-title":"Down\u2019s syndrome and atherosclerosis.","volume":"76","author":"Yl\u00e4-Herttuala","year":"1989","journal-title":"Atherosclerosis"},{"issue":"6","key":"2021121018253243200_B5","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1001\/archinte.163.6.705","article-title":"Mortality and cancer incidence among individuals with Down syndrome.","volume":"163","author":"Hill","year":"2003","journal-title":"Arch Intern Med"},{"issue":"pt 2","key":"2021121018253243200_B6","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1046\/j.1469-1809.2001.6520167.x","article-title":"Mortality and cancer incidence in persons with Down\u2019s syndrome, their parents and siblings.","volume":"65","author":"Hermon","year":"2001","journal-title":"Ann Hum Genet"},{"issue":"3","key":"2021121018253243200_B7","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1017\/S0012162205000319","article-title":"Mortality and causes of death in persons with Down syndrome in California.","volume":"47","author":"Day","year":"2005","journal-title":"Dev Med Child Neurol"},{"issue":"9365","key":"2021121018253243200_B8","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1016\/S0140-6736(03)12987-X","article-title":"Down\u2019s syndrome.","volume":"361","author":"Roizen","year":"2003","journal-title":"Lancet"},{"issue":"2","key":"2021121018253243200_B9","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1053\/jada.2003.50025","article-title":"Prevalence of obesity in International Special Olympic athletes as determined by body mass index.","volume":"103","author":"Harris","year":"2003","journal-title":"J Am Diet Assoc"},{"issue":"pt 5","key":"2021121018253243200_B10","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1111\/j.1365-2788.1995.tb00548.x","article-title":"Overweight and obesity amongst Down\u2019s syndrome adults.","volume":"39","author":"Prasher","year":"1995","journal-title":"J Intellect Disabil Res"},{"issue":"246","key":"2021121018253243200_B11","first-page":"1","article-title":"2000 CDC Growth Charts for the United States: methods and development.","author":"Kuczmarski","year":"2002","journal-title":"Vital Health Stat 11"},{"issue":"5","key":"2021121018253243200_B12","doi-asserted-by":"crossref","DOI":"10.1542\/peds.2015-1652","article-title":"Growth charts for children with Down syndrome in the United States.","volume":"136","author":"Zemel","year":"2015","journal-title":"Pediatrics"},{"issue":"4","key":"2021121018253243200_B13","doi-asserted-by":"crossref","first-page":"e20160541","DOI":"10.1542\/peds.2016-0541","article-title":"Body composition and BMI growth charts in children with Down syndrome.","volume":"138","author":"Hatch-Stein","year":"2016","journal-title":"Pediatrics"},{"issue":"9","key":"2021121018253243200_B14","doi-asserted-by":"crossref","first-page":"3208","DOI":"10.1210\/jc.2014-1684","article-title":"A comparison of fat and lean body mass index to BMI for the identification of metabolic syndrome in children and adolescents.","volume":"99","author":"Weber","year":"2014","journal-title":"J Clin Endocrinol Metab"},{"key":"2021121018253243200_B15","unstructured":"Centers for Disease Control and Prevention . Modified z-scores in the CDC growth charts. Available at: https:\/\/www.cdc.gov\/nccdphp\/dnpa\/growthcharts\/resources\/BIV-cutoffs.pdf. Accessed June 26, 2018"},{"issue":"7","key":"2021121018253243200_B16","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1001\/jamapediatrics.2017.0460","article-title":"Tri-ponderal mass index vs body mass index in estimating body fat during adolescence.","volume":"171","author":"Peterson","year":"2017","journal-title":"JAMA Pediatr"},{"issue":"3","key":"2021121018253243200_B17","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1007\/BF02088471","article-title":"Validation of a self-administered instrument to assess stage of adolescent development.","volume":"9","author":"Morris","year":"1980","journal-title":"J Youth Adolesc"},{"issue":"8","key":"2021121018253243200_B18","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1089\/met.2014.0050","article-title":"Lipoprotein insulin resistance index: a lipoprotein particle-derived measure of insulin resistance.","volume":"12","author":"Shalaurova","year":"2014","journal-title":"Metab Syndr Relat Disord"},{"issue":"10","key":"2021121018253243200_B19","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.2337\/diacare.19.10.1138","article-title":"A prospective analysis of the HOMA model. The Mexico City Diabetes Study.","volume":"19","author":"Haffner","year":"1996","journal-title":"Diabetes Care"},{"key":"2021121018253243200_B20","doi-asserted-by":"crossref","first-page":"S62","DOI":"10.2337\/dc10-S062","article-title":"Diagnosis and classification of diabetes mellitus [published correction appears in Diabetes Care. 2010;33(4):e57].","volume":"33","author":"American Diabetes Association","year":"2010","journal-title":"Diabetes Care"},{"issue":"7","key":"2021121018253243200_B21","doi-asserted-by":"crossref","first-page":"e93","DOI":"10.2337\/dc10-0646","article-title":"Reduced time points to calculate the composite index.","volume":"33","author":"DeFronzo","year":"2010","journal-title":"Diabetes Care"},{"issue":"11","key":"2021121018253243200_B22","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1001\/archinte.161.11.1413","article-title":"Non-high-density lipoprotein cholesterol level as a predictor of cardiovascular disease mortality.","volume":"161","author":"Cui","year":"2001","journal-title":"Arch Intern Med"},{"issue":"20","key":"2021121018253243200_B23","doi-asserted-by":"crossref","first-page":"2537","DOI":"10.1161\/01.CIR.0000038496.57570.06","article-title":"Non-high-density lipoprotein cholesterol levels predict five-year outcome in the Bypass Angioplasty Revascularization Investigation (BARI).","volume":"106","author":"Bittner","year":"2002","journal-title":"Circulation"},{"issue":"1","key":"2021121018253243200_B24","doi-asserted-by":"crossref","first-page":"16","DOI":"10.2337\/diacare.26.1.16","article-title":"Non-HDL cholesterol as a predictor of cardiovascular disease in type 2 diabetes: the strong heart study.","volume":"26","author":"Lu","year":"2003","journal-title":"Diabetes Care"},{"issue":"1","key":"2021121018253243200_B25","doi-asserted-by":"crossref","first-page":"6","DOI":"10.5551\/jat.11.6","article-title":"Non-HDL cholesterol as a measure of atherosclerotic risk.","volume":"11","author":"Packard","year":"2004","journal-title":"J Atheroscler Thromb"},{"issue":"21","key":"2021121018253243200_B26","doi-asserted-by":"crossref","first-page":"2341","DOI":"10.1001\/archinte.166.21.2341","article-title":"Prediction of coronary artery calcium in young adults using the Pathobiological Determinants of Atherosclerosis in Youth (PDAY) risk score: the CARDIA study [published correction appears in Arch Intern Med. 2007;167(4):373].","volume":"166","author":"Gidding","year":"2006","journal-title":"Arch Intern Med"},{"issue":"1","key":"2021121018253243200_B27","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1002\/ajmg.a.38512","article-title":"Co-occurring medical conditions in adults with Down syndrome: a systematic review toward the development of health care guidelines.","volume":"176","author":"Capone","year":"2018","journal-title":"Am J Med Genet A"},{"issue":"3","key":"2021121018253243200_B28","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.arcmed.2005.01.005","article-title":"Regulation of plasma triglycerides in insulin resistance and diabetes.","volume":"36","author":"Ginsberg","year":"2005","journal-title":"Arch Med Res"},{"issue":"6","key":"2021121018253243200_B29","doi-asserted-by":"crossref","DOI":"10.1542\/peds.2011-1262","article-title":"Lipid profiles of children with Down syndrome compared with their siblings.","volume":"129","author":"Adelekan","year":"2012","journal-title":"Pediatrics"},{"issue":"pt 4","key":"2021121018253243200_B30","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1111\/j.1365-2788.1992.tb00535.x","article-title":"Lipids and lipoproteins in persons with Down\u2019s syndrome.","volume":"36","author":"Pueschel","year":"1992","journal-title":"J Intellect Disabil Res"},{"issue":"6","key":"2021121018253243200_B31","doi-asserted-by":"crossref","first-page":"464","DOI":"10.4093\/dmj.2014.38.6.464","article-title":"A cross-sectional study of the phenotypes of obesity and insulin resistance in adults with Down syndrome.","volume":"38","author":"Real de Asua","year":"2014","journal-title":"Diabetes Metab J"},{"key":"2021121018253243200_B32","article-title":"Descriptive analysis of anthropometric parameters, lipid profile, glucose and insulin in Mexican population with DOWN syndrome","volume-title":"Proceedings from the 98th Annual Meeting of the Endocrine Society","author":"De la Garza-Hernandez"},{"issue":"9","key":"2021121018253243200_B33","doi-asserted-by":"crossref","first-page":"e0137093","DOI":"10.1371\/journal.pone.0137093","article-title":"Risk of major cardiovascular events in people with Down syndrome.","volume":"10","author":"Sobey","year":"2015","journal-title":"PLoS One"},{"key":"2021121018253243200_B34","doi-asserted-by":"crossref","first-page":"375","DOI":"10.2147\/VHRM.S21273","article-title":"Stiffness of the large arteries in individuals with and without Down syndrome.","volume":"7","author":"Rodrigues","year":"2011","journal-title":"Vasc Health Risk Manag"},{"issue":"10","key":"2021121018253243200_B35","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1016\/j.amjcard.2010.06.079","article-title":"Comparison of intima-media thickness of the carotid artery and cardiovascular disease risk factors in adults with versus without the Down syndrome.","volume":"106","author":"Draheim","year":"2010","journal-title":"Am J Cardiol"},{"issue":"2","key":"2021121018253243200_B36","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1111\/jch.12890","article-title":"Atherosclerotic surrogate markers in adults with Down syndrome: a case-control study.","volume":"19","author":"Parra","year":"2017","journal-title":"J Clin Hypertens (Greenwich)"},{"key":"2021121018253243200_B37","unstructured":"National Down Syndrome Society . Alzheimer\u2019s disease & Down syndrome. 2018. Available at: https:\/\/www.ndss.org\/resources\/alzheimers\/. Accessed June 26, 2018"},{"issue":"22","key":"2021121018253243200_B38","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.1056\/NEJM198906013202203","article-title":"Amyloid A4 protein and its precursor in Down\u2019s syndrome and Alzheimer\u2019s disease.","volume":"320","author":"Rumble","year":"1989","journal-title":"N Engl J Med"},{"key":"2021121018253243200_B39","doi-asserted-by":"crossref","first-page":"170276","DOI":"10.1155\/2012\/170276","article-title":"Neuroinflammation in the aging down syndrome brain; lessons from Alzheimer\u2019s disease.","volume":"2012","author":"Wilcock","year":"2012","journal-title":"Curr Gerontol Geriatr Res"},{"issue":"3","key":"2021121018253243200_B40","first-page":"353","article-title":"Alzheimer\u2019s disease in Down syndrome.","volume":"1","author":"Head","year":"2012","journal-title":"Eur J Neurodegener Dis"},{"issue":"5","key":"2021121018253243200_B41","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1097\/01.JGP.0000310778.20870.ae","article-title":"Cholesterol as a risk factor for dementia and cognitive decline: a systematic review of prospective studies with meta-analysis.","volume":"16","author":"Anstey","year":"2008","journal-title":"Am J Geriatr Psychiatry"},{"issue":"2","key":"2021121018253243200_B42","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1002\/ana.22055","article-title":"Atherosclerosis, dementia, and Alzheimer disease in the Baltimore Longitudinal Study of Aging cohort.","volume":"68","author":"Dolan","year":"2010","journal-title":"Ann Neurol"},{"issue":"4","key":"2021121018253243200_B43","doi-asserted-by":"crossref","first-page":"e60718","DOI":"10.1371\/journal.pone.0060718","article-title":"Mitotic spindle defects and chromosome mis-segregation induced by LDL\/cholesterol-implications for Niemann-Pick C1, Alzheimer\u2019s disease, and atherosclerosis.","volume":"8","author":"Granic","year":"2013","journal-title":"PLoS One"},{"issue":"10","key":"2021121018253243200_B44","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1038\/ejcn.2013.137","article-title":"Resting energy expenditure and adiposity accretion among children with Down syndrome: a 3-year prospective study.","volume":"67","author":"Hill","year":"2013","journal-title":"Eur J Clin Nutr"},{"issue":"11","key":"2021121018253243200_B45","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1111\/j.1365-2788.2012.01605.x","article-title":"Is body mass index a useful measure of excess body fatness in adolescents and young adults with Down syndrome?","volume":"57","author":"Bandini","year":"2013","journal-title":"J Intellect Disabil Res"},{"issue":"4","key":"2021121018253243200_B46","first-page":"417","article-title":"Macrocytosis in Down syndrome.","volume":"95","author":"Wachtel","year":"1991","journal-title":"Am J Ment Retard"},{"issue":"6","key":"2021121018253243200_B47","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1007\/s00125-006-0231-6","article-title":"Increased prevalence of Down\u2019s syndrome in individuals with type 1 diabetes in Denmark: a nationwide population-based study.","volume":"49","author":"Bergholdt","year":"2006","journal-title":"Diabetologia"},{"issue":"6","key":"2021121018253243200_B48","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1007\/s00125-010-1686-z","article-title":"Down\u2019s syndrome in diabetic patients aged &lt;20 years: an analysis of metabolic status, glycaemic control and autoimmunity in comparison with type 1 diabetes.","volume":"53","author":"Rohrer","year":"2010","journal-title":"Diabetologia"},{"issue":"11","key":"2021121018253243200_B49","doi-asserted-by":"crossref","first-page":"2942","DOI":"10.1016\/j.ridd.2014.07.038","article-title":"Evaluation of the impact of abdominal obesity on glucose and lipid metabolism disorders in adults with Down syndrome.","volume":"35","author":"Real de Asua","year":"2014","journal-title":"Res Dev Disabil"},{"issue":"12","key":"2021121018253243200_B50","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1111\/j.1365-2788.2012.01633.x","article-title":"Management and quality indicators of diabetes mellitus in people with intellectual disabilities.","volume":"57","author":"Taggart","year":"2013","journal-title":"J Intellect Disabil Res"},{"key":"2021121018253243200_B51","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/1472-6823-12-22","article-title":"Leptin, insulin and thyroid hormones in a cohort of Egyptian obese Down syndrome children: a comparative study.","volume":"12","author":"Yahia","year":"2012","journal-title":"BMC Endocr Disord"},{"issue":"5","key":"2021121018253243200_B52","doi-asserted-by":"crossref","first-page":"e1006033","DOI":"10.1371\/journal.pgen.1006033","article-title":"A syntenic cross species aneuploidy genetic screen links RCAN1 expression to beta-cell mitochondrial dysfunction in type 2 diabetes","volume":"12","author":"Peiris","year":"2016","journal-title":"PLoS Genet"},{"issue":"19","key":"2021121018253243200_B53","doi-asserted-by":"crossref","first-page":"12363","DOI":"10.1073\/pnas.192445199","article-title":"A role for glutathione peroxidase in protecting pancreatic beta cells against oxidative stress in a model of glucose toxicity.","volume":"99","author":"Tanaka","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"2021121018253243200_B54","doi-asserted-by":"crossref","first-page":"E87","DOI":"10.1152\/ajpendo.00218.2011","article-title":"Glucokinase activation repairs defective bioenergetics of islets of Langerhans isolated from type 2 diabetics.","volume":"302","author":"Doliba","year":"2012","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"1","key":"2021121018253243200_B55","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.cmet.2012.12.005","article-title":"Adaptive downregulation of mitochondrial function in down syndrome.","volume":"17","author":"Helguera","year":"2013","journal-title":"Cell Metab"},{"issue":"5","key":"2021121018253243200_B56","doi-asserted-by":"crossref","first-page":"867","DOI":"10.5664\/jcsm.7126","article-title":"Prevalence of obstructive sleep apnea in children with Down syndrome: a meta-analysis.","volume":"14","author":"Lee","year":"2018","journal-title":"J Clin Sleep Med"},{"issue":"4","key":"2021121018253243200_B57","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1183\/13993003.01430-2015","article-title":"Impact of obstructive sleep apnoea on insulin resistance in nonobese and obese children.","volume":"47","author":"Koren","year":"2016","journal-title":"Eur Respir J"},{"issue":"6","key":"2021121018253243200_B58","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1111\/j.2047-6310.2013.00198.x","article-title":"Obstructive sleep apnoea in obese adolescents and cardiometabolic risk markers.","volume":"9","author":"Watson","year":"2014","journal-title":"Pediatr Obes"}],"container-title":["Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/publications.aap.org\/pediatrics\/article-pdf\/doi\/10.1542\/peds.2019-0137\/1077829\/peds_20190137.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/publications.aap.org\/pediatrics\/article-pdf\/doi\/10.1542\/peds.2019-0137\/1077829\/peds_20190137.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,21]],"date-time":"2024-07-21T03:28:18Z","timestamp":1721532498000},"score":1,"resource":{"primary":{"URL":"https:\/\/publications.aap.org\/pediatrics\/article\/144\/2\/e20190137\/38477\/Cardiometabolic-Risk-and-Body-Composition-in-Youth"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8,1]]},"references-count":58,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2019,8,1]]},"published-print":{"date-parts":[[2019,8,1]]}},"URL":"https:\/\/doi.org\/10.1542\/peds.2019-0137","relation":{},"ISSN":["0031-4005","1098-4275"],"issn-type":[{"value":"0031-4005","type":"print"},{"value":"1098-4275","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,8,1]]},"article-number":"e20190137"}}