{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T17:13:00Z","timestamp":1790615580807,"version":"4.1.0"},"reference-count":32,"publisher":"American Academy of Pediatrics (AAP)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,10,1]]},"abstract":"<jats:sec>\n                  <jats:title>BACKGROUND:<\/jats:title>\n                  <jats:p>Despite the standardization of care, formula feeding varied across sites of the Ohio Perinatal Quality Collaborative (OPQC). We used orchestrated testing (OT) to learn from this variation and improve nonpharmacologic care of infants with neonatal abstinence syndrome (NAS) requiring pharmacologic treatment in Ohio.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS:<\/jats:title>\n                  <jats:p>To test the impact of formula on length of stay (LOS), treatment failure, and weight loss among infants hospitalized with NAS, we compared caloric content (high versus standard) and lactose content (low versus standard) using a 22 factorial design. During October 2015 to June 2016, OPQC sites joined 1 of 4 OT groups. We used response plots to examine the effect of each factor and control charts to track formula use and LOS. We used the OT results to revise the nonpharmacologic bundle and implemented it during 2017.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS:<\/jats:title>\n                  <jats:p>Forty-seven sites caring for 546 NAS infants self-selected into the 4 OT groups. Response plots revealed the benefit of high-calorie formula (HCF) on weight loss, treatment failure, and LOS. The nonpharmacologic treatment bundle was updated to recommend HCF when breastfeeding was not possible. During implementation, HCF use increased, and LOS decreased from 17.1 to 16.4 days across the OPQC.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS:<\/jats:title>\n                  <jats:p>OT revealed that HCF was associated with shorter LOS in OPQC sites. Implementation of a revised nonpharmacologic care bundle was followed by additional LOS improvement in Ohio. Despite some challenges in the implementation of OT, our findings support its usefulness for learning in improvement networks.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1542\/peds.2019-0914","type":"journal-article","created":{"date-parts":[[2020,9,10]],"date-time":"2020-09-10T12:38:15Z","timestamp":1599741495000},"source":"Crossref","is-referenced-by-count":17,"title":["Orchestrated Testing of Formula Type to Reduce Length of Stay in Neonatal Abstinence Syndrome"],"prefix":"10.1542","volume":"146","author":[{"given":"Heather C.","family":"Kaplan","sequence":"first","affiliation":[{"name":"Department of Pediatrics, College of Medicine, University of Cincinnati, Cincinnati, Ohio;"},{"name":"Perinatal Institute,"},{"name":"James M. Anderson Center for Health Systems Excellence, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierce","family":"Kuhnell","sequence":"additional","affiliation":[{"name":"Division of Epidemiology and Biostatistics, Cincinnati Children\u2019s Hospital Medical Center, Cincinnati, Ohio;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele C.","family":"Walsh","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics, Rainbow Babies and Children\u2019s Hospital, Cleveland, Ohio;"},{"name":"Department of Pediatrics, Case Western Reserve University, Cleveland, Ohio;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moira","family":"Crowley","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics, Rainbow Babies and Children\u2019s Hospital, Cleveland, Ohio;"},{"name":"Department of Pediatrics, Case Western Reserve University, Cleveland, Ohio;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"McClead","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Nationwide Children\u2019s Hospital, Columbus, Ohio; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"Wexelblatt","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, College of Medicine, University of Cincinnati, Cincinnati, Ohio;"},{"name":"Perinatal Institute,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Ford","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics, Rainbow Babies and Children\u2019s Hospital, Cleveland, Ohio;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lloyd P.","family":"Provost","sequence":"additional","affiliation":[{"name":"Associates in Process Improvement, Austin, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carole","family":"Lannon","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, College of Medicine, University of Cincinnati, Cincinnati, Ohio;"},{"name":"James M. 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