{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T00:09:33Z","timestamp":1788307773170,"version":"build-2803163510"},"reference-count":24,"publisher":"American Academy of Pediatrics (AAP)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,12,1]]},"abstract":"<jats:p>The live-attenuated varicella vaccine, a routine immunization in the United States since 1995, is both safe and effective. Like wild-type varicella-zoster virus, however, vaccine Oka (vOka) varicella can establish latency and reactivate as herpes zoster, rarely leading to serious disease, particularly among immunocompromised hosts. All but one previously reported cases of reactivated vOka resulting in meningitis have been described in young children who received a single dose of varicella vaccine; less is known about vOka reactivation in older children after the 2-dose vaccine series. We present 2 adolescents with reactivated vOka meningitis, 1 immunocompetent and 1 immunocompromised, both of whom received 2 doses of varicella vaccine many years before as children. Pediatricians should be aware of the potential of vOka varicella to reactivate and cause clinically significant central nervous system disease in vaccinated children and adolescents.<\/jats:p>","DOI":"10.1542\/peds.2019-1522","type":"journal-article","created":{"date-parts":[[2019,11,27]],"date-time":"2019-11-27T13:29:10Z","timestamp":1574861350000},"source":"Crossref","is-referenced-by-count":20,"title":["Vaccine Oka Varicella Meningitis in Two Adolescents"],"prefix":"10.1542","volume":"144","author":[{"given":"Whitney E.","family":"Harrington","sequence":"first","affiliation":[{"name":"Seattle Children\u2019s Hospital, Seattle, Washington;"},{"name":"Department of Pediatrics, University of Washington, Seattle, Washington;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sayonara","family":"Mat\u00f3","sequence":"additional","affiliation":[{"name":"Randall Children\u2019s Hospital at Legacy Emanuel, Portland, Oregon;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauri","family":"Burroughs","sequence":"additional","affiliation":[{"name":"Seattle Children\u2019s Hospital, Seattle, Washington;"},{"name":"Department of Pediatrics, University of Washington, Seattle, Washington;"},{"name":"Fred Hutchinson Cancer Research Center, Seattle, Washington;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul A.","family":"Carpenter","sequence":"additional","affiliation":[{"name":"Seattle Children\u2019s Hospital, Seattle, Washington;"},{"name":"Department of Pediatrics, University of Washington, Seattle, Washington;"},{"name":"Fred Hutchinson Cancer Research Center, Seattle, Washington;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Gershon","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Vagelos School of Physicians and Surgeons, Columbia University, New York, New York; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. 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