{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T19:07:03Z","timestamp":1783019223488,"version":"3.54.6"},"reference-count":25,"publisher":"American Academy of Pediatrics (AAP)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,4,1]]},"abstract":"<jats:sec>\n                  <jats:title>BACKGROUND:<\/jats:title>\n                  <jats:p>The association of dietary fat distribution with markers of subclinical atherosclerosis during early life is unknown. We examined whether success in achieving the main target of an infancy-onset dietary intervention based on the distribution of dietary fat was associated with aortic and carotid intima-media thickness (IMT) and distensibility from childhood to young adulthood.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS:<\/jats:title>\n                  <jats:p>In the prospective randomized controlled Special Turku Coronary Risk Factor Intervention Project trial, personalized dietary counseling was given biannually to healthy children from infancy to young adulthood. The counseling was based on Nordic Nutrition Recommendations, with the main aim of improving the distribution of dietary fat in children\u2019s diets. IMT and distensibility of the abdominal aorta and common carotid artery were measured repeatedly at ages 11 (n = 439), 13 (n = 499), 15 (n = 506), 17 (n = 477), and 19 years (n = 429). The targeted distribution of dietary fat was defined as a ratio of saturated fatty acids to monounsaturated and polyunsaturated fatty acids of &amp;lt;1:2 and as an intake of saturated fatty acids of &amp;lt;10% of energy intake. Participants who met \u22651 of these 2 criteria were defined to achieve the main intervention target.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS:<\/jats:title>\n                  <jats:p>Individuals who achieved the main intervention target had lower aortic IMT (age- and sex-adjusted mean difference 10.4 \u00b5m; 95% confidence interval: 0.3 to 20.5 \u00b5m) and better aortic distensibility (0.13% per 10 mm\u2009Hg; 95% confidence interval: 0.00% to 0.26% per10 mm\u2009Hg) compared with their peers who did not meet the target.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS:<\/jats:title>\n                  <jats:p>Achieving the main target of an infancy-onset dietary intervention, reflecting dietary guidelines, was favorably associated with aortic IMT and distensibility during the early life course. These data support the recommendation of favoring unsaturated fat to enhance arterial health.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1542\/peds.2019-2786","type":"journal-article","created":{"date-parts":[[2020,3,24]],"date-time":"2020-03-24T12:34:20Z","timestamp":1585053260000},"source":"Crossref","is-referenced-by-count":23,"title":["Dietary Fats and Atherosclerosis From Childhood to Adulthood"],"prefix":"10.1542","volume":"145","author":[{"given":"Tomi T.","family":"Laitinen","sequence":"first","affiliation":[{"name":"Research Centre of Applied and Preventive Cardiovascular Medicine and Centre for Population Health Research and"},{"name":"Paavo Nurmi Centre, Sports and Exercise Medicine Unit, Departments of Physical Activity and Health and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel","family":"Nuotio","sequence":"additional","affiliation":[{"name":"Research Centre of Applied and Preventive Cardiovascular Medicine and Centre for Population Health Research and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suvi P.","family":"Rovio","sequence":"additional","affiliation":[{"name":"Research Centre of Applied and Preventive Cardiovascular Medicine and Centre for Population Health Research and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harri","family":"Niinikoski","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics and Adolescent Medicine,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Juonala","sequence":"additional","affiliation":[{"name":"Medicine, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Costan G.","family":"Magnussen","sequence":"additional","affiliation":[{"name":"Research Centre of Applied and Preventive Cardiovascular Medicine and Centre for Population Health Research and"},{"name":"Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eero","family":"Jokinen","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology, University of Helsinki and Hospital for Children and Adolescents, Helsinki, Finland; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanna","family":"Lagstr\u00f6m","sequence":"additional","affiliation":[{"name":"Public Health, University of Turku, Turku, Finland;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antti","family":"Jula","sequence":"additional","affiliation":[{"name":"Department of Chronic Disease Prevention, Institute for Health and Welfare, Turku, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorma S.A.","family":"Viikari","sequence":"additional","affiliation":[{"name":"Medicine, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tapani","family":"R\u00f6nnemaa","sequence":"additional","affiliation":[{"name":"Medicine, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olli","family":"Simell","sequence":"additional","affiliation":[{"name":"Research Centre of Applied and Preventive Cardiovascular Medicine and Centre for Population Health Research and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olli T.","family":"Raitakari","sequence":"additional","affiliation":[{"name":"Research Centre of Applied and Preventive Cardiovascular Medicine and Centre for Population Health Research and"},{"name":"Clinical Physiology and Nuclear Medicine, University of Turku and Turku University Hospital, Turku, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katja","family":"Pahkala","sequence":"additional","affiliation":[{"name":"Research Centre of Applied and Preventive Cardiovascular Medicine and Centre for Population Health Research and"},{"name":"Paavo Nurmi Centre, Sports and Exercise Medicine Unit, Departments of Physical Activity and Health and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"417","published-online":{"date-parts":[[2020,4,1]]},"reference":[{"issue":"4","key":"2021121013132484800_B1","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1161\/CIRCULATIONAHA.106.628875","article-title":"Prediction of clinical cardiovascular events with carotid intima-media thickness: a systematic review and meta-analysis","volume":"115","author":"Lorenz","year":"2007","journal-title":"Circulation"},{"issue":"2","key":"2021121013132484800_B2","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/j.atherosclerosis.2009.10.018","article-title":"Measurement of arterial distensibility and compliance to assess prognosis","volume":"209","author":"Haluska","year":"2010","journal-title":"Atherosclerosis"},{"key":"2021121013132484800_B3","doi-asserted-by":"crossref","DOI":"10.26530\/OAPEN_483279","volume-title":"Nordic Nutrition Recommendations 2012. 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