{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T21:16:14Z","timestamp":1790630174429,"version":"4.1.0"},"reference-count":34,"publisher":"American Academy of Pediatrics (AAP)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,12,1]]},"abstract":"<jats:p>Crohn disease (CD) is a chronic inflammatory disease, and its incidence in children is rising. Despite extensive reports and investigations, the pathogenesis of CD has not been clearly elucidated, particularly in regard to triggering factors. A genetic predisposition is considered important when investigating the mechanism leading to CD, and the discovery of new CD-associated genes has increased our understanding of its immunopathogenesis and improved the efficacy of its treatment of CD. Early detection and treatment (eg, as children) with gene-based precision therapy can effectively prevent complications related to CD. In this case, a Chinese Han boy with CD associated with a mutation of tumor necrosis factor \u03b1-induced protein 3 was treated with recombinant human tumor necrosis factor-a receptor II:IgG Fc fusion protein. We suspected the boy had CD because of chronic abdominal pain, aphthous stomatitis, moderate anemia, a high erythrocyte sedimentation rate (36\u201379 mm\/h), multiple intestinal ulcers, knee joint swelling, and a tumor necrosis factor \u03b1-induced protein 3 mutation. After total enteral nutrition and hormone therapy for 5 months, his abdominal pain and joint symptoms did not improve, so we started gene-based precision therapy with recombinant human tumor necrosis factor-a receptor II: IgG Fc fusion protein, which may play an important role in restricting TNF-\u03b1-induced NF-\u03baB signaling. After 3 weeks, inflammation indicators were within the normal range, and multiple ulcers and joint symptoms were relieved. The present case demonstrates a safe therapeutic schedule that leads to rapid improvements in the clinical and biochemical status of patients with CD.<\/jats:p>","DOI":"10.1542\/peds.2019-3416","type":"journal-article","created":{"date-parts":[[2020,11,11]],"date-time":"2020-11-11T13:25:13Z","timestamp":1605101113000},"source":"Crossref","is-referenced-by-count":8,"title":["Knee Joint Swelling at Presentation: A Case of Pediatric Crohn Disease With a TNFAIP3 Mutation"],"prefix":"10.1542","volume":"146","author":[{"given":"Dongmei","family":"Zou","sequence":"first","affiliation":[{"name":"Division of Gastroenterology, Shenzhen Children\u2019s Hospital, Shenzhen, Guangdong, China; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaoming","family":"Zhou","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Shenzhen Children\u2019s Hospital, Shenzhen, Guangdong, China; 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