{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T23:50:58Z","timestamp":1791417058688,"version":"4.3.3"},"reference-count":86,"publisher":"American Academy of Pediatrics (AAP)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,4,1]]},"abstract":"<jats:sec>\n                    <jats:title>CONTEXT:<\/jats:title>\n                    <jats:p>Migraine is a common neurologic disorder in children and adolescents. However, a comparison of multiple nonpharmacological treatments is lacking.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>OBJECTIVE:<\/jats:title>\n                    <jats:p>To examine whether nonpharmacological treatments are more effective than waiting list and whether there are differences between interventions regarding efficacy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DATA SOURCES:<\/jats:title>\n                    <jats:p>Systematic review and network meta-analysis of studies in Medline, Cochrane, Embase, and PsycINFO published through August 5, 2019.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>STUDY SELECTION:<\/jats:title>\n                    <jats:p>Randomized controlled trials of nonpharmacological treatments in children and adolescents diagnosed with episodic migraine.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DATA EXTRACTION:<\/jats:title>\n                    <jats:p>Effect sizes, calculated as standardized mean differences (SMDs) for the primary outcome efficacy, were assessed in a random-effects model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>Twelve studies (N = 576) were included. When interventions were classified into groups on the basis of similarity of treatment components, self-administered treatments, biofeedback, relaxation, psychological treatments, and psychological placebos were significantly more effective than waiting list with effect sizes ranging between SMD = 1.14 (95% confidence interval, 0.09 to 2.19) for long-term psychological placebos to SMD = 1.44 (95% confidence interval, 0.26 to 2.62) for short-term self-administered treatments. However, when all interventions were examined individually (ie, 1 node per intervention), none were significantly more effective compared with waiting list, mainly because of lack of statistical power.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>LIMITATIONS:<\/jats:title>\n                    <jats:p>Because of our focus on pediatric migraine, only a small number of studies could be included.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>Our findings reveal that components of nonpharmacological interventions are effective in treating pediatric migraine. Some effects have to be interpreted carefully because they are based on small studies. Future researchers should identify factors associated with individual responses in large, multicentered studies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1542\/peds.2019-4107","type":"journal-article","created":{"date-parts":[[2021,3,9]],"date-time":"2021-03-09T04:25:56Z","timestamp":1615263956000},"source":"Crossref","is-referenced-by-count":17,"title":["Nonpharmacological Interventions for Pediatric Migraine: A Network Meta-analysis"],"prefix":"10.1542","volume":"147","author":[{"given":"Helen","family":"Koechlin","sequence":"first","affiliation":[{"name":"Division of Clinical Psychology and Psychotherapy, University of Basel, Basel, Switzerland;"},{"name":"Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children\u2019s Hospital, Harvard Medical School, Harvard University, Boston, Massachusetts;"},{"name":"Contributed equally as co-first authors."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joe","family":"Kossowsky","sequence":"additional","affiliation":[{"name":"Division of Clinical Psychology and Psychotherapy, University of Basel, Basel, Switzerland;"},{"name":"Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children\u2019s Hospital, Harvard Medical School, Harvard University, Boston, Massachusetts;"},{"name":"Contributed equally as co-first authors."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thanh Lan","family":"Lam","sequence":"additional","affiliation":[{"name":"Institute of Medical Psychology, LMU Munich, Munich, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Barthel","sequence":"additional","affiliation":[{"name":"Institute of Medical Psychology, LMU Munich, Munich, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"Gaab","sequence":"additional","affiliation":[{"name":"Division of Clinical Psychology and Psychotherapy, University of Basel, Basel, Switzerland;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles B.","family":"Berde","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children\u2019s Hospital, Harvard Medical School, Harvard University, Boston, Massachusetts;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guido","family":"Schwarzer","sequence":"additional","affiliation":[{"name":"Institute of Medical Biometry and Statistics, University of Freiburg, Breisgau, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"Linde","sequence":"additional","affiliation":[{"name":"Institute of General Practice and Health Services Research, School of Medicine, Technical University Munich, Munich, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"Meissner","sequence":"additional","affiliation":[{"name":"Institute of Medical Psychology, LMU Munich, Munich, Germany;"},{"name":"Division of Integrative Health Promotion, Coburg University of Applied Sciences, Coburg, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cosima","family":"Locher","sequence":"additional","affiliation":[{"name":"Division of Clinical Psychology and Psychotherapy, University of Basel, Basel, Switzerland;"},{"name":"Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children\u2019s Hospital, Harvard Medical School, Harvard University, Boston, Massachusetts;"},{"name":"Faculty of Health, University of Plymouth, Plymouth, United Kingdom; 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