{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T06:21:59Z","timestamp":1774333319930,"version":"3.50.1"},"reference-count":9,"publisher":"American Academy of Pediatrics (AAP)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,4,1]]},"abstract":"<jats:p>Coronavirus disease 2019 is associated with a postinfectious multisystem inflammatory syndrome in children (MIS-C). This syndrome is marked by cytokine storm and multiorgan dysfunction, often affecting the gastrointestinal tract, the heart, and the hematopoietic system. We describe the case of a 16-year-old boy with an initial presentation of severe inflammatory bowel disease and concurrent MIS-C. He presented with abdominal pain, diarrhea, and hematochezia and met criteria for the systemic inflammatory response syndrome. Laboratory inflammatory profiling revealed markedly elevated ferritin, D-dimer, C-reactive protein, soluble interleukin 2, and interleukin 6 levels. Endoscopy and colonoscopy revealed severe active gastroduodenitis, patchy colitis, and a normal-appearing terminal ileum. The patient was treated with a combination of steroids, intravenous immunoglobulin, and infliximab, and his symptoms slowly resolved over a 3-week period. In this case, we describe coincident MIS-C with a remarkably severe and difficult-to-treat initial presentation of inflammatory bowel disease and highlight the need to investigate the effect of coronavirus disease 2019 and MIS-C on inflammatory disorders.<\/jats:p>","DOI":"10.1542\/peds.2020-027763","type":"journal-article","created":{"date-parts":[[2021,1,7]],"date-time":"2021-01-07T09:40:06Z","timestamp":1610012406000},"source":"Crossref","is-referenced-by-count":20,"title":["Inflammatory Bowel Disease Presenting With Concurrent COVID-19 Multisystem Inflammatory Syndrome"],"prefix":"10.1542","volume":"147","author":[{"given":"Katherine F.","family":"Sweeny","sequence":"first","affiliation":[{"name":"Division of Gastroenterology, Hepatology and Nutrition and"},{"name":"Contributed equally as co-first authors"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanjia J.","family":"Zhang","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology and Nutrition and"},{"name":"Contributed equally as co-first authors"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bonnie","family":"Crume","sequence":"additional","affiliation":[{"name":"Departments of Medicine, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Colin A.","family":"Martz","sequence":"additional","affiliation":[{"name":"Departments of Medicine, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melissa M.","family":"Blessing","sequence":"additional","affiliation":[{"name":"Pathology, Boston Children\u2019s Hospital, Boston, Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stacy A.","family":"Kahn","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology and Nutrition 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