{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T23:42:06Z","timestamp":1788306126424,"version":"build-2803163510"},"reference-count":28,"publisher":"American Academy of Pediatrics (AAP)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,9,1]]},"abstract":"<jats:sec>\n                    <jats:title>OBJECTIVES<\/jats:title>\n                    <jats:p>To characterize the demographics, comorbidities, symptoms, in-hospital treatments, and health outcomes among children and adolescents diagnosed or hospitalized with coronavirus disease 2019 (COVID-19) and to compare them in secondary analyses with patients diagnosed with previous seasonal influenza in 2017\u20132018.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>International network cohort using real-world data from European primary care records (France, Germany, and Spain), South Korean claims and US claims, and hospital databases. We included children and adolescents diagnosed and\/or hospitalized with COVID-19 at age &amp;lt;18 between January and June 2020. We described baseline demographics, comorbidities, symptoms, 30-day in-hospital treatments, and outcomes including hospitalization, pneumonia, acute respiratory distress syndrome, multisystem inflammatory syndrome in children, and death.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>A total of 242\u2009158 children and adolescents diagnosed and 9769 hospitalized with COVID-19 and 2\u2009084\u2009180 diagnosed with influenza were studied. Comorbidities including neurodevelopmental disorders, heart disease, and cancer were more common among those hospitalized with versus diagnosed with COVID-19. Dyspnea, bronchiolitis, anosmia, and gastrointestinal symptoms were more common in COVID-19 than influenza. In-hospital prevalent treatments for COVID-19 included repurposed medications (&amp;lt;10%) and adjunctive therapies: systemic corticosteroids (6.8%\u20137.6%), famotidine (9.0%\u201328.1%), and antithrombotics such as aspirin (2.0%\u201321.4%), heparin (2.2%\u201318.1%), and enoxaparin (2.8%\u201314.8%). Hospitalization was observed in 0.3% to 1.3% of the cohort diagnosed with COVID-19, with undetectable (n &amp;lt; 5 per database) 30-day fatality. Thirty-day outcomes including pneumonia and hypoxemia were more frequent in COVID-19 than influenza.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>Despite negligible fatality, complications including hospitalization, hypoxemia, and pneumonia were more frequent in children and adolescents with COVID-19 than with influenza. Dyspnea, anosmia, and gastrointestinal symptoms could help differentiate diagnoses. A wide range of medications was used for the inpatient management of pediatric COVID-19.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1542\/peds.2020-042929","type":"journal-article","created":{"date-parts":[[2021,5,28]],"date-time":"2021-05-28T04:33:38Z","timestamp":1622176418000},"source":"Crossref","is-referenced-by-count":43,"title":["Thirty-Day Outcomes of Children and Adolescents With COVID-19: An International Experience"],"prefix":"10.1542","volume":"148","author":[{"given":"Talita","family":"Duarte-Salles","sequence":"first","affiliation":[{"name":"aFundaci\u00f3 Institut Universitari per a la Recerca a l\u2019Atenci\u00f3 Prim\u00e0ria de Salut Jordi Gol i Gurina, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Vizcaya","sequence":"additional","affiliation":[{"name":"bBayer Pharmaceuticals, Sant Joan Despi, 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Clinical management of COVID-19: living guidance. Available at: https:\/\/www.who.int\/publications\/i\/item\/clinical-management-of-covid-19. Accessed June 11, 2020"},{"key":"2022081818421345300_B10","unstructured":"Royal College of Paediatrics and Child Health\n          . COVID-19 - guidance for paediatric services. Available at: https:\/\/www.rcpch.ac.uk\/resources\/covid-19-guidance-paediatric-services. Accessed June 11, 2020"},{"key":"2022081818421345300_B11","unstructured":"National Institutes of Health\n          . COVID-19 treatment guidelines: special considerations in children. Available at: https:\/\/www.covid19treatmentguidelines.nih.gov\/special-populations\/children\/. 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