{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T11:45:47Z","timestamp":1778586347109,"version":"3.51.4"},"reference-count":22,"publisher":"American Academy of Pediatrics (AAP)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,11,1]]},"abstract":"<jats:p>Lymphomatous involvement of the larynx is a rare entity. We present a case of atypical laryngotracheitis as the initial manifestation of non-Hodgkin\u2019s lymphoma in a pediatric patient. The diagnosis was aided through the use of microbial cell-free DNA (mcfDNA) testing, which detected the presence of Epstein-Barr virus in the patient\u2019s plasma. This enabled the consideration of an Epstein-Barr virus\u2013related lymphoproliferative process, leading to additional workup and the final diagnosis of lymphoma. To our knowledge, this is the first case of mcfDNA testing leading not simply to an infectious organism, but further to a new oncologic diagnosis. Plasma mcfDNA testing has the potential to inform clinical practice beyond classic infectious disease manifestations. In this article, we review both the possible future applications and the areas of further investigation that remain.<\/jats:p>","DOI":"10.1542\/peds.2020-047662","type":"journal-article","created":{"date-parts":[[2021,10,29]],"date-time":"2021-10-29T08:30:17Z","timestamp":1635496217000},"source":"Crossref","is-referenced-by-count":2,"title":["Next-Generation Sequencing as an Auxiliary Tool in Pediatric Laryngeal Lymphoma Diagnosis"],"prefix":"10.1542","volume":"148","author":[{"given":"Tina","family":"Munjal","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2014Head & Neck Surgery, School of Medicine, Stanford University, Palo Alto, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neelaysh","family":"Vukkadala","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head & Neck Surgery, School of Medicine, Stanford University, Palo Alto, 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