{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T22:58:26Z","timestamp":1777417106982,"version":"3.51.4"},"reference-count":25,"publisher":"American Academy of Pediatrics (AAP)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,8,1]]},"abstract":"<jats:sec><jats:title>OBJECTIVES:<\/jats:title><jats:p>Acute nystagmus (AN) is an uncommon neurologic sign in children presenting to pediatric emergency departments. We described the epidemiology, clinical features, and underlying causes of AN in a large cohort of children, aiming at identifying features associated with higher risk of severe underlying urgent conditions (UCs).<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS:<\/jats:title><jats:p>Clinical records of all patients aged 0 to 18 years presenting for AN to the pediatric emergency departments of 9 Italian hospitals in an 8-year period were retrospectively reviewed. Clinical and demographic features and the underlying causes were analyzed. A logistic regression model was applied to detect predictive variables associated with a higher risk of UCs.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS:<\/jats:title><jats:p>A total of 206 patients with AN were included (male-to-female ratio: 1.01; mean age: 8 years 11 months). The most frequently associated symptoms were headache (43.2%) and vertigo (42.2%). Ataxia (17.5%) and strabismus (13.1%) were the most common neurologic signs. Migraine (25.7%) and vestibular disorders (14.1%) were the most common causes of AN. Idiopathic infantile nystagmus was the most common cause in infants &amp;lt;1 year of age. UCs accounted for 18.9% of all cases, mostly represented by brain tumors (8.3%). Accordant with the logistic model, cranial nerve deficits, ataxia, or strabismus were strongly associated with an underlying UC. Presence of vertigo or attribution of a nonurgent triage code was associated with a reduced risk of UCs.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS:<\/jats:title><jats:p>AN should be considered an alarming finding in children given the risk of severe UCs. Cranial nerve palsy, ataxia, and strabismus should be considered red flags during the assessment of a child with AN.<\/jats:p><\/jats:sec>","DOI":"10.1542\/peds.2020-0484","type":"journal-article","created":{"date-parts":[[2020,7,30]],"date-time":"2020-07-30T12:25:25Z","timestamp":1596111925000},"source":"Crossref","is-referenced-by-count":9,"title":["Characteristics of Acute Nystagmus in the Pediatric Emergency Department"],"prefix":"10.1542","volume":"146","author":[{"given":"Giacomo","family":"Garone","sequence":"first","affiliation":[{"name":"University Hospital Pediatric Department, Bambino Ges\u00f9 Children\u2019s Hospital, IRCCS, Tor Vergata University, Rome Italy;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agnese","family":"Suppiej","sequence":"additional","affiliation":[{"name":"Neurophtalmology Programme, Padova Paediatric University Hospital, Padova, Italy;"},{"name":"Pediatric Section, Department of Medical Sciences, University of Ferrara, Ferrara, 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