{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T01:57:56Z","timestamp":1790560676951,"version":"4.1.0"},"reference-count":32,"publisher":"American Academy of Pediatrics (AAP)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,8,1]]},"abstract":"<jats:sec>\n                  <jats:title\/>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>OBJECTIVES<\/jats:title>\n                  <jats:p>In a large health system, we evaluated the effectiveness of electronic health record patient portal reminders in increasing pediatric influenza vaccination rates.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>We conducted an intention-to-treat randomized clinical trial of 22\u2009046 children from 6 months to &amp;lt;18 years of age in 53 primary care practices. Patients (or parent and\/or proxies) who were active portal users were randomly assigned to receive reminder messages framed as gains or losses or no messages. They were separately randomly assigned to receive a precommitment message before the influenza season. The primary outcome was receipt of \u22651 seasonal influenza vaccinations. Additionally, children 6 months to &amp;lt;3 years of age due for a second influenza vaccine were randomly assigned to receive a reminder or no reminder for the second vaccination.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>First-dose influenza vaccination rates were 56.9% in the control group, 58.0% in the loss-frame reminders group (P = .07), and 58.0% in the gain-frame group (P = .47). Rates were 58.3% in the precommitment group versus 57.0% in the control group (P = .11). Adjusted risk ratios for first vaccination were 1.02 (95% confidence interval [CI]: 1.00\u20131.04) for loss-frame reminders, 1.01 (95% CI: 0.98\u20131.05) for gain-frame reminders, and 1.02 (95% CI: 1.00\u20131.04) for precommitment messages versus controls. Second-dose vaccination rates were 44.1% in the control group and 55.0% in the reminder group, with an adjusted risk ratio of 1.25 (95% CI: 1.07\u20131.45).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>Patient portal reminders for influenza vaccines in children, whether framed as gains or losses, did not increase first-dose influenza vaccination rates but were highly effective for the second dose of the vaccine.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1542\/peds.2020-048413","type":"journal-article","created":{"date-parts":[[2021,7,28]],"date-time":"2021-07-28T08:25:16Z","timestamp":1627460716000},"source":"Crossref","is-referenced-by-count":17,"title":["Patient Portal Reminders for Pediatric Influenza Vaccinations: A Randomized Clinical Trial"],"prefix":"10.1542","volume":"148","author":[{"given":"Carlos","family":"Lerner","sequence":"first","affiliation":[{"name":"Department of Pediatrics and Mattel Children\u2019s Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Albertin","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Mattel Children\u2019s Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandra","family":"Casillas","sequence":"additional","affiliation":[{"name":"Department of Medicine, David Geffen School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O. 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