{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T03:33:54Z","timestamp":1790220834721,"version":"4.1.0"},"reference-count":33,"publisher":"American Academy of Pediatrics (AAP)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,7,1]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND AND OBJECTIVES:<\/jats:title>\n                    <jats:p>Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a newly identified pathogen that mainly spreads by droplets. Most published studies have been focused on adult patients with coronavirus disease 2019 (COVID-19), but data concerning pediatric patients are limited. In this study, we aimed to determine epidemiological characteristics and clinical features of pediatric patients with COVID-19.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>We reviewed and analyzed data on pediatric patients with laboratory-confirmed COVID-19, including basic information, epidemiological history, clinical manifestations, laboratory and radiologic findings, treatment, outcome, and follow-up results.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>A total of 74 pediatric patients with COVID-19 were included in this study. Of the 68 case patients whose epidemiological data were complete, 65 (65 of 68; 95.59%) were household contacts of adults. Cough (32.43%) and fever (27.03%) were the predominant symptoms of 44 (59.46%) symptomatic patients at onset of the illness. Abnormalities in leukocyte count were found in 23 (31.08%) children, and 10 (13.51%) children presented with abnormal lymphocyte count. Of the 34 (45.95%) patients who had nucleic acid testing results for common respiratory pathogens, 19 (51.35%) showed coinfection with other pathogens other than SARS-CoV-2. Ten (13.51%) children had real-time reverse transcription polymerase chain reaction analysis for fecal specimens, and 8 of them showed prolonged existence of SARS-CoV-2 RNA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>Pediatric patients with COVID-19 presented with distinct epidemiological, clinical, and radiologic characteristics from adult patients. Nearly one-half of the infected children had coinfection with other common respiratory pathogens. It is not uncommon for pediatric patients to have prolonged fecal shedding of SARS-CoV-2 RNA during the convalescent phase.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1542\/peds.2020-0961","type":"journal-article","created":{"date-parts":[[2020,5,6]],"date-time":"2020-05-06T08:25:11Z","timestamp":1588753511000},"source":"Crossref","is-referenced-by-count":189,"title":["Coinfection and Other Clinical Characteristics of COVID-19 in Children"],"prefix":"10.1542","volume":"146","author":[{"given":"Qin","family":"Wu","sequence":"first","affiliation":[{"name":"Qingdao Women and Children\u2019s Hospital of Qingdao University, Qingdao, China;"},{"name":"Contributed equally as co-first authors."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhan","family":"Xing","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China; and"},{"name":"Contributed equally as co-first authors."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Shi","sequence":"additional","affiliation":[{"name":"Qingdao Women and Children\u2019s Hospital of Qingdao University, Qingdao, China;"},{"name":"Contributed equally as co-first authors."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjie","family":"Li","sequence":"additional","affiliation":[{"name":"Qingdao Women and Children\u2019s Hospital of Qingdao University, Qingdao, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Gao","sequence":"additional","affiliation":[{"name":"Qingdao Women and Children\u2019s Hospital of Qingdao University, Qingdao, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silin","family":"Pan","sequence":"additional","affiliation":[{"name":"Qingdao Women and Children\u2019s Hospital of Qingdao University, Qingdao, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Wang","sequence":"additional","affiliation":[{"name":"Wuhan Children\u2019s Hospital and Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendi","family":"Wang","sequence":"additional","affiliation":[{"name":"Qingdao Women and Children\u2019s Hospital of Qingdao University, Qingdao, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quansheng","family":"Xing","sequence":"additional","affiliation":[{"name":"Qingdao Women and Children\u2019s Hospital of Qingdao University, Qingdao, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"417","published-online":{"date-parts":[[2020,7,1]]},"reference":[{"key":"2021121021252738500_B1","unstructured":"World Health Organization\n          . 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