{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T22:58:42Z","timestamp":1789253922636,"version":"build-2803163510"},"reference-count":40,"publisher":"American Academy of Pediatrics (AAP)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,3,1]]},"abstract":"<jats:sec><jats:title>BACKGROUND AND OBJECTIVES:<\/jats:title><jats:p>Previous studies suggest that children of mothers with certain chronic conditions may be at increased risk of cerebral palsy (CP). We explored possible associations between 17 maternal chronic conditions and CP in offspring.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS:<\/jats:title><jats:p>We conducted a prospective cohort study of Norwegian children born in 1990\u20132012 and surviving to 2 years of age. Information on maternal chronic conditions during pregnancy were extracted from the Medical Birth Registry of Norway (1990\u20132012). Information on chronic conditions in mothers and fathers recorded in the Norwegian Patient Registry (2008\u20132014) was available for a subset of children. CP diagnoses were extracted from the National Insurance Scheme (1990\u20132014) and the Norwegian Patient Registry (2008\u20132014). We estimated relative risks (RRs) and 95% confidence intervals (CIs) of CP in offspring of parents with chronic conditions compared with the general population using log binominal regression models.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS:<\/jats:title><jats:p>A total of 1\u2009360\u2009149 Norwegian children, including 3575 children with CP (2.6 per 1000 live births), fulfilled the inclusion criteria. The highest risk of CP was among offspring of mothers with type 2 diabetes (RR 3.2; 95% CI 1.8\u20135.4), lupus erythematosus (RR 2.7; 95% CI 0.9\u20138.3), type 1 diabetes (RR 2.2; 95% CI 1.4\u20133.4), and Crohn disease (RR 2.1; 95% CI 1.0\u20134.1) during pregnancy. No increased risks were seen for offspring of fathers with chronic conditions.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS:<\/jats:title><jats:p>Several maternal chronic conditions were associated with increased risk of CP in offspring. Maternal autoimmune disorders carried a particular risk.<\/jats:p><\/jats:sec>","DOI":"10.1542\/peds.2020-1137","type":"journal-article","created":{"date-parts":[[2021,2,18]],"date-time":"2021-02-18T09:27:02Z","timestamp":1613640422000},"source":"Crossref","is-referenced-by-count":19,"title":["Maternal Chronic Conditions and Risk of Cerebral Palsy in Offspring: A National Cohort Study"],"prefix":"10.1542","volume":"147","author":[{"given":"Marianne S.","family":"Str\u00f8m","sequence":"first","affiliation":[{"name":"Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway;"},{"name":"Department of Pediatrics, Haukeland University Hospital, Bergen, Norway;"},{"name":"Department of Health Registry Research and Development, Norwegian Institute of Public Health, Bergen, Norway;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mette C.","family":"Toll\u00e5nes","sequence":"additional","affiliation":[{"name":"Norwegian Organization for Quality Improvement of Laboratory Examinations, Haraldsplass Deaconess Hospital, Bergen, Norway;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allen J.","family":"Wilcox","sequence":"additional","affiliation":[{"name":"Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Durham, North Carolina; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rolv Terje","family":"Lie","sequence":"additional","affiliation":[{"name":"Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway;"},{"name":"Centre for Fertility and Health, Norwegian Institute of Public Health, Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingeborg","family":"Forthun","sequence":"additional","affiliation":[{"name":"Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dag","family":"Moster","sequence":"additional","affiliation":[{"name":"Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway;"},{"name":"Department of Pediatrics, Haukeland University Hospital, Bergen, Norway;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"417","published-online":{"date-parts":[[2021,3,1]]},"reference":[{"key":"2021120906343553700_B1","first-page":"8","article-title":"A report: the definition and classification of cerebral palsy April 2006. 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