{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T22:41:46Z","timestamp":1772232106244,"version":"3.50.1"},"reference-count":15,"publisher":"American Academy of Pediatrics (AAP)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,8,1]]},"abstract":"<jats:p>We describe 2 children with persistent fever and profuse diarrhea who developed signs of mucocutaneous involvement (conjunctivitis, fissured lips, skin rash, erythema, and edema of the hands and feet). Blood tests revealed elevated markers of inflammation, lymphopenia, thrombocytopenia, and complement consumption. Afterward, diffuse edema with hypoalbuminemia appeared in the context of a capillary leak syndrome. In both patients, repeated nasal swabs were negative for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), but each patient had high titers of immunoglobulin G and immunoglobulin M against the SARS-CoV-2 virus. The negative PCR results in the presence of immunoglobulin M and immunoglobulin G suggested that the inflammatory response developed in the late phase of viral infection, when SARS-CoV-2 was not detectable in the upper airway. In this report, we describe patients with what we propose to name as SARS-CoV-2\u2013induced Kawasaki-like hyperinflammatory syndrome. SARS-CoV-2\u2013induced Kawasaki-like hyperinflammatory syndrome seems to be caused by a delayed response to SARS-CoV-2. It resembles Kawasaki disease complicated by macrophage activation syndrome, although it has peculiar features, such as prodromal diarrhea, capillary leak syndrome, and myocardial dysfunction. Intravenous corticosteroid treatment appears to be helpful.<\/jats:p>","DOI":"10.1542\/peds.2020-1711","type":"journal-article","created":{"date-parts":[[2020,5,21]],"date-time":"2020-05-21T08:25:18Z","timestamp":1590049518000},"source":"Crossref","is-referenced-by-count":187,"title":["SARS-CoV-2\u2013Induced Kawasaki-Like Hyperinflammatory Syndrome: A Novel COVID Phenotype in Children"],"prefix":"10.1542","volume":"146","author":[{"given":"Francesco","family":"Licciardi","sequence":"first","affiliation":[{"name":"Department of Pediatric and Public Health Sciences, University of Torino, Turin, Italy;"},{"name":"Regina Margherita Children\u2019s Hospital, AOU Citt\u00e0 della Salute e della Scienza di Torino, Turin, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giulia","family":"Pruccoli","sequence":"additional","affiliation":[{"name":"Department of Pediatric and Public Health Sciences, University of Torino, Turin, Italy;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Denina","sequence":"additional","affiliation":[{"name":"Department of Pediatric and Public Health Sciences, University of Torino, Turin, Italy;"},{"name":"Regina Margherita Children\u2019s Hospital, AOU Citt\u00e0 della Salute e della Scienza di Torino, Turin, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emilia","family":"Parodi","sequence":"additional","affiliation":[{"name":"Department of Pediatric and Public Health Sciences, University of Torino, Turin, Italy;"},{"name":"Regina Margherita Children\u2019s Hospital, AOU Citt\u00e0 della Salute e della Scienza di Torino, Turin, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuela","family":"Taglietto","sequence":"additional","affiliation":[{"name":"Regina Margherita Children\u2019s Hospital, AOU Citt\u00e0 della Salute e della Scienza di Torino, Turin, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergio","family":"Rosati","sequence":"additional","affiliation":[{"name":"Department of Veterinary Sciences, University of Turin, Turin, Italy; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Davide","family":"Montin","sequence":"additional","affiliation":[{"name":"Department of Pediatric and Public Health Sciences, University of Torino, Turin, Italy;"},{"name":"Regina Margherita Children\u2019s Hospital, AOU Citt\u00e0 della Salute e della Scienza di Torino, Turin, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"417","published-online":{"date-parts":[[2020,8,1]]},"reference":[{"issue":"10223","key":"2021121019503976700_B1","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0140-6736(20)30183-5","article-title":"Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China","volume":"395","author":"Huang","year":"2020","journal-title":"Lancet"},{"key":"2021121019503976700_B2","unstructured":"Task force COVID-19 del Dipartimento Malattie Infettive e Servizio di Informatica Istituto Superiore di Sanit\u00e0\n          . 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