{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T03:00:29Z","timestamp":1792119629067,"version":"4.4.0"},"reference-count":47,"publisher":"American Academy of Pediatrics (AAP)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,12,1]]},"abstract":"<jats:sec>\n                  <jats:title>OBJECTIVES<\/jats:title>\n                  <jats:p>Safety studies assessing the association between the entire recommended childhood immunization schedule and autoimmune diseases, such as type 1 diabetes mellitus (T1DM), are lacking. To examine the association between the recommended immunization schedule and T1DM, we conducted a retrospective cohort study of children born between 2004 and 2014 in 8 US health care organizations that participate in the Vaccine Safety Datalink.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>Three measures of the immunization schedule were assessed: average days undervaccinated (ADU), cumulative antigen exposure, and cumulative aluminum exposure. T1DM incidence was identified by International Classification of Disease codes. Cox proportional hazards models were used to analyze associations between the 3 exposure measures and T1DM incidence. Adjusted hazard ratios (aHRs) and 95% confidence intervals (CIs) were calculated. Models were adjusted for sex, race and ethnicity, birth year, mother\u2019s age, birth weight, gestational age, number of well-child visits, and study site.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>In a cohort of 584\u2009171 children, the mean ADU was 38 days, the mean cumulative antigen exposure was 263 antigens (SD = 54), and the mean cumulative aluminum exposure was 4.11 mg (SD = 0.73). There were 1132 incident cases of T1DM. ADU (aHR = 1.01; 95% CI, 0.99\u20131.02) and cumulative antigen exposure (aHR = 0.98; 95% CI, 0.97\u20131.00) were not associated with T1DM. Cumulative aluminum exposure &amp;gt;3.00 mg was inversely associated with T1DM (aHR = 0.77; 95% CI, 0.60\u20130.99).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>The recommended schedule is not positively associated with the incidence of T1DM in children. These results support the safety of the recommended childhood immunization schedule.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1542\/peds.2021-051910","type":"journal-article","created":{"date-parts":[[2021,11,8]],"date-time":"2021-11-08T09:25:15Z","timestamp":1636363515000},"source":"Crossref","is-referenced-by-count":12,"title":["The Childhood Vaccination Schedule and the Lack of Association With Type 1 Diabetes"],"prefix":"10.1542","volume":"148","author":[{"given":"Jason M.","family":"Glanz","sequence":"first","affiliation":[{"name":"aInstitute for Health Research, Kaiser Permanente Colorado, Denver, Colorado"},{"name":"bDepartment of Epidemiology, Colorado School of Public Health, University of Colorado, Aurora, Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina L.","family":"Clarke","sequence":"additional","affiliation":[{"name":"aInstitute for Health Research, Kaiser Permanente Colorado, Denver, Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew F.","family":"Daley","sequence":"additional","affiliation":[{"name":"aInstitute for Health Research, Kaiser Permanente Colorado, Denver, Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo Ann","family":"Shoup","sequence":"additional","affiliation":[{"name":"aInstitute for Health Research, Kaiser Permanente Colorado, Denver, Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon J.","family":"Hambidge","sequence":"additional","affiliation":[{"name":"cDenver Health and Hospital Authority, Denver, Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua T.B.","family":"Williams","sequence":"additional","affiliation":[{"name":"cDenver Health and Hospital Authority, Denver, Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holly C.","family":"Groom","sequence":"additional","affiliation":[{"name":"dKaiser 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