{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T19:18:12Z","timestamp":1793992692594,"version":"4.8.0"},"reference-count":37,"publisher":"American Academy of Pediatrics (AAP)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,6,1]]},"abstract":"<jats:sec>\n                    <jats:title\/>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>Development of cardiovascular disease in adults has been directly linked to an adverse metabolic phenotype. While there is evidence that development of these risk factors in childhood persists into adulthood and the development of cardiovascular disease, less is known about whether these risk factors are associated with target organ damage during adolescence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>We collected data from 379 adolescents (mean age 15.5, 60% male) with blood pressure between the 75th and 95th percentile to determine if there is a metabolic phenotype that predicts cardiovascular changes (left ventricular mass, systolic and diastolic function, pulse wave velocity, and renal function). We determined the number of risk factors for cardiovascular disease (hypertension, dyslipidemia, obesity, and insulin resistance) present in each participant. Generalized linear models were constructed to determine if the number of cardiovascular risk factors (CVRFs) were associated with measures of target organ damage.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>The number of CVRFs present were associated with statistically significant differences in increased left ventricular mass index, increased pulse wave velocity, decreased peak longitudinal strain, urine albumin to creatine ratio and echocardiographic parameters of diastolic dysfunction. Generalized linear models showed that dyslipidemia and insulin resistance were independently associated with markers of diastolic dysfunction (P \u2264 .05) while increased blood pressure was associated with all makers of target organ damage (P \u2264 .03).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>These data suggest the of the number of CVRFs present is independently associated with early changes in markers of target organ damage during adolescence.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1542\/peds.2021-054201","type":"journal-article","created":{"date-parts":[[2022,5,3]],"date-time":"2022-05-03T04:15:18Z","timestamp":1651551318000},"source":"Crossref","is-referenced-by-count":31,"title":["Cardiovascular Risk Factors and Target Organ Damage in Adolescents: The SHIP AHOY Study"],"prefix":"10.1542","volume":"149","author":[{"given":"Joshua J","family":"Price","sequence":"first","affiliation":[{"name":"aSeattle Children\u2019s Hospital, Seattle, Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elaine M.","family":"Urbina","sequence":"additional","affiliation":[{"name":"bCincinnati Children\u2019s Hospital, Cincinnati, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristen","family":"Carlin","sequence":"additional","affiliation":[{"name":"aSeattle Children\u2019s Hospital, Seattle, Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Becker","sequence":"additional","affiliation":[{"name":"bCincinnati Children\u2019s Hospital, Cincinnati, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen R","family":"Daniels","sequence":"additional","affiliation":[{"name":"cChildren\u2019s Hospital of Colorado, Denver, Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bonita E","family":"Falkner","sequence":"additional","affiliation":[{"name":"dDepartments of Pediatrics and Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Ferguson","sequence":"additional","affiliation":[{"name":"eChildrens Hospital Boston, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Coral","family":"Hanevold","sequence":"additional","affiliation":[{"name":"aSeattle Children\u2019s Hospital, Seattle, Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen R","family":"Hooper","sequence":"additional","affiliation":[{"name":"fSchool of Medicine, University of North Carolina, Chapel Hill, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie R","family":"Ingelfinger","sequence":"additional","affiliation":[{"name":"jMass General Hospital for Children at MGH, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc B.","family":"Lande","sequence":"additional","affiliation":[{"name":"gDepartment of Pediatrics, University of Rochester Medical Center, Rochester, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa J","family":"Martin","sequence":"additional","affiliation":[{"name":"bCincinnati Children\u2019s Hospital, Cincinnati, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Meyers","sequence":"additional","affiliation":[{"name":"hChildrens Hospital of Philadelphia, Philadelphia, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Mitsnefes","sequence":"additional","affiliation":[{"name":"bCincinnati Children\u2019s Hospital, Cincinnati, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Rosner","sequence":"additional","affiliation":[{"name":"iDepartment of MedicineHarvard University, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua","family":"Samuels","sequence":"additional","affiliation":[{"name":"kUniversity of Texas Health Sciences Center, Houston, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph T.","family":"Flynn","sequence":"additional","affiliation":[{"name":"aSeattle Children\u2019s Hospital, Seattle, Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"417","published-online":{"date-parts":[[2022,5,3]]},"reference":[{"issue":"17","key":"2023110214102158600_B1","doi-asserted-by":"crossref","first-page":"2735","DOI":"10.1161\/CIRCULATIONAHA.105.169404","article-title":"Diagnosis and management of the metabolic syndrome: an American Heart Association\/National Heart, Lung, and Blood Institute scientific 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