{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T06:56:46Z","timestamp":1793861806092,"version":"4.6.1"},"reference-count":13,"publisher":"American Academy of Pediatrics (AAP)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,6,1]]},"abstract":"<jats:p>Although rare in pediatrics, ischemic priapism carries significant risk of erectile dysfunction if not treated promptly. We report a case of idiopathic ischemic priapism in a male aged 14 years, refractory to traditional therapies, including aspiration\/irrigation, phenylephrine injection, and distal shunt. However, the priapism resolved after intracavernosal injections of tissue plasminogen activator (tPA) with preservation of normal erectile function. To our knowledge, this is the first reported case of intracavernosal tPA for treatment of pediatric priapism. tPA may be a useful management option for recalcitrant ischemic priapism in pediatric patients and may prevent devastating outcomes such as lifelong erectile dysfunction.<\/jats:p>","DOI":"10.1542\/peds.2021-054941","type":"journal-article","created":{"date-parts":[[2022,5,11]],"date-time":"2022-05-11T08:09:03Z","timestamp":1652256543000},"source":"Crossref","is-referenced-by-count":3,"title":["Acute Management of Prolonged, Recalcitrant Priapism in a Pediatric Patient"],"prefix":"10.1542","volume":"149","author":[{"given":"Rachael","family":"Sherrer","sequence":"first","affiliation":[{"name":"aDepartments of Urology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Otto","sequence":"additional","affiliation":[{"name":"bDivision of Hematology, Oncology & Bone Marrow Transplant, Department of Pediatrics, University of Wisconsin, Madison, Wisconsin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sushant","family":"Srinivasan","sequence":"additional","affiliation":[{"name":"cPediatrics"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krista","family":"Grinde","sequence":"additional","affiliation":[{"name":"bDivision of Hematology, Oncology & Bone Marrow Transplant, Department of Pediatrics, University of Wisconsin, Madison, Wisconsin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walid A.","family":"Farhat","sequence":"additional","affiliation":[{"name":"aDepartments of Urology"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"417","published-online":{"date-parts":[[2022,5,11]]},"reference":[{"issue":"1","key":"2023110214095944900_B1","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.jpurol.2013.07.024","article-title":"Priapism in children: a comprehensive review and clinical guideline","volume":"10","author":"Donaldson","year":"2014","journal-title":"J Pediatr Urol"},{"issue":"5","key":"2023110214095944900_B2","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1016\/S0090-4295(01)00941-4","article-title":"Incidence of priapism in the general population","volume":"57","author":"Eland","year":"2001","journal-title":"Urology"},{"issue":"6","key":"2023110214095944900_B3","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1097\/00043426-199911000-00013","article-title":"Prevalence of priapism in children and adolescents with sickle cell anemia","volume":"21","author":"Mantadakis","year":"1999","journal-title":"J Pediatr Hematol Oncol"},{"issue":"8","key":"2023110214095944900_B4","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1007\/BF03022958","article-title":"Management of priapism in a child with sickle cell anemia; successful outcome using epidural analgesia","volume":"54","author":"McHardy","year":"2007","journal-title":"Can J Anaesth"},{"issue":"7","key":"2023110214095944900_B5","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1111\/aas.12314","article-title":"Priapism following continuous thoracic epidural anaesthesia: emergency or a benign condition?","volume":"58","author":"Fransen van de Putte","year":"2014","journal-title":"Acta Anaesthesiol Scand"},{"issue":"2","key":"2023110214095944900_B6","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1016\/S0022-5347(05)66012-0","article-title":"Successful treatment of recalcitrant priapism using intercorporeal injection of tissue plasminogen activator","volume":"166","author":"Rutchik","year":"2001","journal-title":"J Urol"},{"issue":"8","key":"2023110214095944900_B7","doi-asserted-by":"crossref","first-page":"e1118","DOI":"10.1097\/MPH.0000000000001998","article-title":"Stuttering priapism in a teenage boy: lesson to be learnt","volume":"43","author":"Sachdeva","year":"2021","journal-title":"J Pediatr Hematol Oncol"},{"issue":"23","key":"2023110214095944900_B8","doi-asserted-by":"crossref","first-page":"3551","DOI":"10.1182\/blood-2014-09-551887","article-title":"How I treat priapism","volume":"125","author":"Anele","year":"2015","journal-title":"Blood"},{"issue":"6","key":"2023110214095944900_B9","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1093\/bja\/87.6.935","article-title":"Epidural analgesia in a child with sickle cell disease complicated by acute abdominal pain and priapism","volume":"87","author":"Labat","year":"2001","journal-title":"Br J Anaesth"},{"issue":"6","key":"2023110214095944900_B10","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1177\/0310057X9302100627","article-title":"Treatment of priapism with epidural anaesthesia","volume":"21","author":"Corke","year":"1993","journal-title":"Anaesth Intensive Care"},{"issue":"11","key":"2023110214095944900_B11","doi-asserted-by":"crossref","first-page":"2082","DOI":"10.1016\/j.jpedsurg.2008.02.006","article-title":"A modification of Winter\u2019s shunt in the treatment of pediatric low-flow priapism","volume":"43","author":"Raveenthiran","year":"2008","journal-title":"J Pediatr Surg"},{"issue":"6","key":"2023110214095944900_B12","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1016\/S0022-5347(17)49370-0","article-title":"Intracorporeal cavernosa streptokinase as adjuvant therapy in the delayed treatment of idiopathic priapism","volume":"133","author":"Gibel","year":"1985","journal-title":"J Urol"},{"issue":"3","key":"2023110214095944900_B13","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1016\/S0022-5347(17)36752-6","article-title":"A new therapeutic concept for long-lasting iatrogenic priapism: a case report","volume":"148","author":"Freymann","year":"1992","journal-title":"J Urol"}],"container-title":["Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/publications.aap.org\/pediatrics\/article-pdf\/doi\/10.1542\/peds.2021-054941\/1554342\/peds_2021054941.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/publications.aap.org\/pediatrics\/article-pdf\/doi\/10.1542\/peds.2021-054941\/1554342\/peds_2021054941.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,2]],"date-time":"2023-11-02T14:10:25Z","timestamp":1698934225000},"score":1,"resource":{"primary":{"URL":"https:\/\/publications.aap.org\/pediatrics\/article\/149\/6\/e2021054941\/187011\/Acute-Management-of-Prolonged-Recalcitrant"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,11]]},"references-count":13,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2022,5,11]]},"published-print":{"date-parts":[[2022,6,1]]}},"URL":"https:\/\/doi.org\/10.1542\/peds.2021-054941","relation":{},"ISSN":["0031-4005","1098-4275"],"issn-type":[{"value":"0031-4005","type":"print"},{"value":"1098-4275","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,11]]},"article-number":"e2021054941"}}