{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T03:01:31Z","timestamp":1774926091197,"version":"3.50.1"},"reference-count":31,"publisher":"American Academy of Pediatrics (AAP)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,11,1]]},"abstract":"<jats:sec>\n                  <jats:title>OBJECTIVES<\/jats:title>\n                  <jats:p>To evaluate outcomes of neonates born to mothers with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection during pregnancy, the dynamics of placental transfer of maternal antibodies, and its persistence during infancy.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>Cohort study enrolling neonates born to mothers with SARS-CoV-2 infection in pregnancy. All infants were evaluated at birth. Those born to women with infection onset within 2 weeks before delivery were excluded from further analyses. Remaining infants underwent cerebral and abdominal ultrasound, fundoscopy evaluation, and were enrolled in a 12 month follow-up. Qualitative immunoglobulin G (IgG)\/immunoglobulin M and quantitative IgG to S1\/S2 subunits of spike protein were assessed in mother\u2013neonate dyads within 48 hours postdelivery and during follow-up.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>Between April 2020 and April 2021, 130 of 2745 (4.7%) neonates were born to mothers with SARS-CoV-2 infection in pregnancy, with 106 of 130 infections diagnosed before 2 weeks before delivery. Rates of preterm and cesarean delivery were comparable between women with and without infection (6% vs 8%, P = .57; 22% vs 32%, P = .06). No clinical or instrumental abnormalities were detected at birth or during follow-up. There was a positive correlation between maternal and neonatal SARS-CoV-2 IgG levels (r = 0.81, P &amp;lt; .001). Transplacental transfer ratio was higher after second-trimester maternal infections as compared with first and third trimester (P = .03). SARS-CoV-2 IgG level progressively decreased in all infants, with 89 of 92 (97%) infants seronegative at 6 months of age.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>Clinical outcomes were favorable in all infants. Matching peak IgG level after infection and higher IgG transplacental transfer might result in the most durable neonatal passive immunity.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1542\/peds.2022-056206","type":"journal-article","created":{"date-parts":[[2022,10,26]],"date-time":"2022-10-26T08:15:33Z","timestamp":1666772133000},"source":"Crossref","is-referenced-by-count":18,"title":["Infants Born Following SARS-CoV-2 Infection in Pregnancy"],"prefix":"10.1542","volume":"150","author":[{"given":"Maria Grazia","family":"Capretti","sequence":"first","affiliation":[{"name":"aNICU"},{"name":"*Co-first authors."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Concetta","family":"Marsico","sequence":"additional","affiliation":[{"name":"aNICU"},{"name":"gDepartments of Medical and Surgical Sciences"},{"name":"*Co-first authors."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liliana","family":"Gabrielli","sequence":"additional","affiliation":[{"name":"bMicrobiology Unit"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caterina","family":"Vocale","sequence":"additional","affiliation":[{"name":"cRegional Reference Center for Microbiological Emergencies (CRREM)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Santo","family":"Arcuri","sequence":"additional","affiliation":[{"name":"aNICU"},{"name":"gDepartments of Medical and Surgical Sciences"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuliana","family":"Simonazzi","sequence":"additional","affiliation":[{"name":"bMicrobiology Unit"},{"name":"dObstetric Unit"},{"name":"gDepartments of Medical and Surgical Sciences"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna Rita","family":"Piccinini","sequence":"additional","affiliation":[{"name":"eOphthalmology Unit"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Brandolini","sequence":"additional","affiliation":[{"name":"fOtorhinolaryngology and Audiology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tiziana","family":"Lazzarotto","sequence":"additional","affiliation":[{"name":"bMicrobiology Unit"},{"name":"hSpecialized, Experimental, and Diagnostic Medicine, University of Bologna, Bologna, Italy"},{"name":"**Co-last authors."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luigi Tommaso","family":"Corvaglia","sequence":"additional","affiliation":[{"name":"aNICU"},{"name":"gDepartments of Medical and Surgical Sciences"},{"name":"**Co-last authors."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"417","published-online":{"date-parts":[[2022,10,26]]},"reference":[{"issue":"8","key":"2023110816582764900_B1","doi-asserted-by":"crossref","first-page":"920","DOI":"10.5858\/arpa.2020-0211-SA","article-title":"Infections in pregnancy with COVID-19 and other respiratory RNA virus diseases are rarely, if ever, transmitted to the fetus: experiences with coronaviruses, parainfluenza, metapneumovirus respiratory syncytial virus, and influenza","volume":"144","author":"Schwartz","year":"2020","journal-title":"Arch Pathol Lab Med"},{"key":"2023110816582764900_B2","unstructured":"World Health Organization\n          . Definition and categorization of the timing of mother-to-child transmission of SARS-CoV-2. Available at: https:\/\/www.who.int\/publications\/i\/item\/WHO-2019-nCoV-mother-to-child-transmission-2021.1. 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