{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T05:40:47Z","timestamp":1791265247531,"version":"4.1.0"},"reference-count":39,"publisher":"American Academy of Pediatrics (AAP)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,8,1]]},"abstract":"<jats:sec>\n                  <jats:title>BACKGROUND<\/jats:title>\n                  <jats:p>It is important to examine adolescent and young adult (AYA) children\u2019s long-term psychosocial and behavioral adaptation to disclosure of maternal BRCA-positive carrier status (BRCA+) to inform approaches for familial cancer risk communication, education, and counseling.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>Mothers underwent BRCA genetic testing 1 to 5 years earlier. Group differences in AYAs' self-reported outcomes were analyzed by maternal health and carrier status, and child age and sex.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>A total of N = 272 AYAs were enrolled: 76.1% of their mothers were breast or ovarian cancer survivors and 17.3% were BRCA+. AYAs\u2019 cancer risk behavior (tobacco and alcohol use, physical activity) and psychologic distress levels did not vary by maternal status. In bivariate analyses, AYAs of cancer-surviving mothers believed themselves to be at greater risk for, and were more knowledgeable about, cancer than AYAs of mothers without cancer. AYAs of BRCA+ mothers were more concerned about cancer, held stronger beliefs about genetic risk, and placed a higher value on learning about genetics. In adjusted models, maternal cancer history (not BRCA+) remained associated with AYAs\u2019 greater perceptions of cancer risk (P = .002), and knowledge about cancer (P = .03) and its causes (P = .002).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>Disclosing maternal BRCA+ status did not influence children\u2019s lifestyle behavior or adversely affect quality of life long term. AYAs of BRCA+ mothers were more aware of and interested in genetic risk information. Such families may benefit from support to promote open communication about genetic testing choices.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1542\/peds.2022-056339","type":"journal-article","created":{"date-parts":[[2022,7,21]],"date-time":"2022-07-21T03:08:54Z","timestamp":1658372934000},"source":"Crossref","is-referenced-by-count":5,"title":["Long-Term Adaptation Among Adolescent and Young Adult Children to Familial Cancer Risk"],"prefix":"10.1542","volume":"150","author":[{"given":"Glynnis A.","family":"McDonnell","sequence":"first","affiliation":[{"name":"aLombardi Comprehensive Cancer Center, Georgetown University, Washington, District of Columbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beth N.","family":"Peshkin","sequence":"additional","affiliation":[{"name":"aLombardi Comprehensive Cancer Center, Georgetown University, Washington, District of Columbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiffani 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