{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T00:00:25Z","timestamp":1788307225388,"version":"build-2803163510"},"reference-count":22,"publisher":"American Academy of Pediatrics (AAP)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,9,1]]},"abstract":"<jats:p>Rubella vaccine is usually given in combination with measles and mumps vaccines as a measles-mumps-rubella vaccination. Because it contains live attenuated virus, its use is contraindicated during pregnancy. However, since the introduction of rubella vaccine, no cases of congenital rubella syndrome have been reported following vaccination during pregnancy. We report a case of a female infant, born to a woman inadvertently vaccinated with measles-mumps-rubella vaccination early in pregnancy, who manifested a phenotype of cardiac and neurologic defects, neurodevelopmental delay, and lymphocytopenia consistent with congenital rubella syndrome.<\/jats:p>","DOI":"10.1542\/peds.2022-057627","type":"journal-article","created":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T04:18:54Z","timestamp":1692937134000},"source":"Crossref","is-referenced-by-count":12,"title":["Congenital Rubella Syndrome Following Rubella Vaccination During Pregnancy"],"prefix":"10.1542","volume":"152","author":[{"given":"Elise","family":"Bouthry","sequence":"first","affiliation":[{"name":"aDepartment of Virology, Angers University Hospital, Angers, France"},{"name":"bGroupe de Recherche sur les Infections pendant la Grossesse (GRIG), Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Crystele","family":"Queinnec","sequence":"additional","affiliation":[{"name":"cPaediatric Medicine Department, Cornouaille Hospital Centre, Quimper, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Vauzelle","sequence":"additional","affiliation":[{"name":"dD\u00e9partement de Sant\u00e9 Publique, Centre de R\u00e9f\u00e9rence sur les Agents T\u00e9ratog\u00e8nes (CRAT), AP-HP.Sorbonne Universit\u00e9, H\u00f4pital Trousseau, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christelle","family":"Vauloup-Fellous","sequence":"additional","affiliation":[{"name":"bGroupe de Recherche sur les Infections pendant la Grossesse (GRIG), Paris, France"},{"name":"eDivision of Virology, WHO Rubella National Reference Laboratory, Department of Biology Genetics and PUI, Paris Saclay University Hospital, APHP, Paris, France"},{"name":"fINSERM U1193, Universit\u00e9 Paris Saclay, Villejuif, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"417","published-online":{"date-parts":[[2023,8,25]]},"reference":[{"issue":"RR-8","key":"2023111414370904700_B1","first-page":"1","article-title":"Measles, mumps, and rubella--vaccine use and strategies for elimination of measles, rubella, and congenital rubella syndrome and control of mumps: recommendations of the Advisory Committee on Immunization Practices (ACIP)","volume":"47","author":"Watson","year":"1998","journal-title":"MMWR Recomm Rep"},{"issue":"1","key":"2023111414370904700_B2","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1002\/ajmg.a.30225","article-title":"Pregnancy outcome following rubella vaccination: a prospective controlled study","volume":"130A","author":"Bar-Oz","year":"2004","journal-title":"Am J Med Genet A"},{"issue":"17","key":"2023111414370904700_B3","doi-asserted-by":"crossref","first-page":"3558","DOI":"10.1016\/j.vaccine.2006.02.001","article-title":"Inadvertent rubella vaccination of pregnant women: evaluation of possible transplacental infection with rubella vaccine","volume":"24","author":"Hamkar","year":"2006","journal-title":"Vaccine"},{"key":"2023111414370904700_B4","doi-asserted-by":"crossref","first-page":"S722","DOI":"10.1093\/infdis\/jir408","article-title":"Pregnancy outcomes following rubella vaccination: a prospective study in the state of Rio de Janeiro, Brazil, 2001-2002","volume":"204","author":"da Silva e S\u00e1","year":"2011","journal-title":"J Infect Dis"},{"issue":"1","key":"2023111414370904700_B5","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.reprotox.2007.09.002","article-title":"Prospective evaluation of pregnant women vaccinated against rubella in southern Brazil","volume":"25","author":"Minussi","year":"2008","journal-title":"Reprod Toxicol"},{"key":"2023111414370904700_B6","doi-asserted-by":"crossref","first-page":"S713","DOI":"10.1093\/infdis\/jir489","article-title":"Rubella vaccination of unknowingly pregnant women during mass campaigns for rubella and congenital rubella syndrome elimination, the Americas 2001-2008","volume":"204","author":"Castillo-Sol\u00f3rzano","year":"2011","journal-title":"J Infect Dis"},{"issue":"9","key":"2023111414370904700_B7","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1097\/INF.0b013e318124a9f4","article-title":"Fetal risk associated with rubella vaccination during pregnancy","volume":"26","author":"Badilla","year":"2007","journal-title":"Pediatr Infect Dis J"},{"key":"2023111414370904700_B8","doi-asserted-by":"crossref","first-page":"S737","DOI":"10.1093\/infdis\/jir419","article-title":"Rubella vaccination of unknowingly pregnant women: the S\u00e3o Paulo experience, 2001","volume":"204","author":"Sato","year":"2011","journal-title":"J Infect Dis"},{"key":"2023111414370904700_B9","doi-asserted-by":"crossref","first-page":"S745","DOI":"10.1093\/infdis\/jir442","article-title":"Rubella vaccination of unknowingly pregnant women during 2006 mass campaign in Argentina","volume":"204","author":"Pardon","year":"2011","journal-title":"J Infect Dis"},{"key":"2023111414370904700_B10","volume-title":"Manual for the Laboratory Diagnosis of Measles and Rubella Virus Infection","author":"World Health Organization","year":"2007","edition":"2nd ed."},{"issue":"32","key":"2023111414370904700_B11","first-page":"337","article-title":"Rubella virus nomenclature update: 2013","volume":"88","year":"2013","journal-title":"Wkly Epidemiol Rec"},{"issue":"10332","key":"2023111414370904700_B12","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1016\/S0140-6736(21)02691-X","article-title":"Rubella","volume":"399","author":"Winter","year":"2022","journal-title":"Lancet"},{"issue":"5","key":"2023111414370904700_B13","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1016\/j.vaccine.2019.11.070","article-title":"Safety profile of rubella vaccine administered to pregnant women: a systematic review of pregnancy related adverse events following immunisation, including congenital rubella syndrome and congenital rubella infection in the foetus or infant","volume":"38","author":"Mangtani","year":"2020","journal-title":"Vaccine"},{"issue":"1","key":"2023111414370904700_B14","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1002\/(SICI)1096-9071(200005)61:1<155::AID-JMV25>3.0.CO;2-O","article-title":"Persistent fetal rubella vaccine virus infection following inadvertent vaccination during early pregnancy","volume":"61","author":"Hofmann","year":"2000","journal-title":"J Med Virol"},{"key":"2023111414370904700_B15","doi-asserted-by":"crossref","first-page":"S178","DOI":"10.1086\/522136","article-title":"Varicella vaccine exposure during pregnancy: data from 10 Years of the pregnancy registry","volume":"197","author":"Wilson","year":"2008","journal-title":"J Infect Dis"},{"issue":"RR-4","key":"2023111414370904700_B16","first-page":"1","article-title":"Prevention of varicella: recommendations of the Advisory Committee on Immunization Practices (ACIP)","volume":"56","author":"Marin","year":"2007","journal-title":"MMWR Recomm Rep"},{"issue":"6","key":"2023111414370904700_B17","doi-asserted-by":"crossref","first-page":"taaa138","DOI":"10.1093\/jtm\/taaa138","article-title":"Safety of yellow fever vaccination in pregnancy: findings from a cohort of active duty US military women","volume":"27","author":"Hall","year":"2020","journal-title":"J Travel Med"},{"issue":"3","key":"2023111414370904700_B18","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/0035-9203(93)90156-K","article-title":"Yellow fever vaccination and pregnancy: a four-year prospective study","volume":"87","author":"Nasidi","year":"1993","journal-title":"Trans R Soc Trop Med Hyg"},{"issue":"2","key":"2023111414370904700_B19","doi-asserted-by":"crossref","first-page":"359","DOI":"10.4269\/ajtmh.2012.11-0525","article-title":"The safety of yellow fever vaccine 17D or 17DD in children, pregnant women, HIV+ individuals, and older persons: systematic review","volume":"86","author":"Thomas","year":"2012","journal-title":"Am J Trop Med Hyg"},{"key":"2023111414370904700_B20","unstructured":"Centers for Disease Control and Prevention\n          . Yellow fever vaccine, pregnancy, and conception. Available at: https:\/\/www.cdc.gov\/yellowfever\/vaccine\/vaccine-pregnancy.html. Accessed December 3, 2021"},{"key":"2023111414370904700_B21","unstructured":"Mes Vaccins.net\n          . Stamaril. Available at: https:\/\/www.mesvaccins.net\/web\/vaccines\/35-stamaril#vaccin_grossesse. Accessed December 3, 2021"},{"key":"2023111414370904700_B22","unstructured":"World Health Organization\n          . International travel and health. Available at: https:\/\/www.who.int\/ith\/ITH_EN_2012_WEB_1.2.pdf. Accessed December 3, 2021"}],"container-title":["Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/publications.aap.org\/pediatrics\/article-pdf\/doi\/10.1542\/peds.2022-057627\/1567401\/peds.2022-057627.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/publications.aap.org\/pediatrics\/article-pdf\/doi\/10.1542\/peds.2022-057627\/1567401\/peds.2022-057627.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,14]],"date-time":"2023-11-14T09:39:35Z","timestamp":1699954775000},"score":1,"resource":{"primary":{"URL":"https:\/\/publications.aap.org\/pediatrics\/article\/152\/3\/e2022057627\/193758\/Congenital-Rubella-Syndrome-Following-Rubella"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,25]]},"references-count":22,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2023,8,25]]},"published-print":{"date-parts":[[2023,9,1]]}},"URL":"https:\/\/doi.org\/10.1542\/peds.2022-057627","relation":{},"ISSN":["0031-4005","1098-4275"],"issn-type":[{"value":"0031-4005","type":"print"},{"value":"1098-4275","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,8,25]]},"article-number":"e2022057627"}}