{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T08:44:29Z","timestamp":1769071469398,"version":"3.49.0"},"reference-count":19,"publisher":"American Academy of Pediatrics (AAP)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,8,1]]},"abstract":"<jats:p>Aortic dissection is often a fatal condition if not recognized and treated emergently. Fortunately, it is extremely rare in children and adolescents. We report a case of an adolescent boy who survived an aortic dissection due to severe aortic root dilation. A comprehensive history and physical examination, including family history, can facilitate an early diagnosis of connective tissue diseases, such as Loeys-Dietz syndrome (LDS).<\/jats:p>","DOI":"10.1542\/peds.2022-057694","type":"journal-article","created":{"date-parts":[[2023,7,14]],"date-time":"2023-07-14T08:08:55Z","timestamp":1689322135000},"source":"Crossref","is-referenced-by-count":3,"title":["Aortic Dissection in a Young Patient With Unsuspected Aortopathy"],"prefix":"10.1542","volume":"152","author":[{"given":"Yalile","family":"Perez","sequence":"first","affiliation":[{"name":"aDepartment of Pediatric and Adolescent Medicine, Division of Pediatric Cardiology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. Yasir","family":"Qureshi","sequence":"additional","affiliation":[{"name":"aDepartment of Pediatric and Adolescent Medicine, Division of Pediatric Cardiology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dusica","family":"Babovic-Vuksanovic","sequence":"additional","affiliation":[{"name":"bDepartment of Clinical Genomics, Mayo Clinic, Rochester, Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bryan","family":"Cannon","sequence":"additional","affiliation":[{"name":"aDepartment of Pediatric and Adolescent Medicine, Division of Pediatric Cardiology"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"417","published-online":{"date-parts":[[2023,7,14]]},"reference":[{"issue":"1","key":"2023111414362172300_B1","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1378\/chest.122.1.311","article-title":"Clinical, diagnostic, and management perspectives of aortic dissection","volume":"122","author":"Khan","year":"2002","journal-title":"Chest"},{"issue":"2","key":"2023111414362172300_B2","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1177\/000992280003900201","article-title":"Etiologic factors of acute aortic dissection in children and young adults","volume":"39","author":"Fikar","year":"2000","journal-title":"Clin Pediatr (Phila)"},{"issue":"1","key":"2023111414362172300_B3","doi-asserted-by":"crossref","first-page":"e46","DOI":"10.1016\/j.jccase.2010.08.001","article-title":"Aortic dissection and rupture in an 11-year-old child: a case report","volume":"3","author":"Eun","year":"2010","journal-title":"J Cardiol Cases"},{"issue":"2","key":"2023111414362172300_B4","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1159\/000094530","article-title":"Weight lifting and aortic dissection: more evidence for a connection","volume":"107","author":"Hatzaras","year":"2007","journal-title":"Cardiology"},{"issue":"9","key":"2023111414362172300_B5","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1016\/j.amjcard.2007.06.039","article-title":"Role of exertion or emotion as inciting events for acute aortic dissection","volume":"100","author":"Hatzaras","year":"2007","journal-title":"Am J Cardiol"},{"issue":"2","key":"2023111414362172300_B6","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1510\/icvts.2009.202234","article-title":"Acute aortic dissection occurring during the butterfly stroke in a 12-year-old boy","volume":"9","author":"Uchida","year":"2009","journal-title":"Interact Cardiovasc Thorac Surg"},{"issue":"6","key":"2023111414362172300_B7","doi-asserted-by":"crossref","first-page":"E23","DOI":"10.1002\/clc.20383","article-title":"Aortic dissection in childhood and adolescence: an analysis of occurrences over a 10-year interval in New York State","volume":"32","author":"Fikar","year":"2009","journal-title":"Clin Cardiol"},{"issue":"4","key":"2023111414362172300_B8","doi-asserted-by":"crossref","first-page":"215","DOI":"10.4070\/kcj.2013.43.4.215","article-title":"Aortopathy in congenital heart disease in adults: aortic dilatation with decreased aortic elasticity that impacts negatively on left ventricular function","volume":"43","author":"Niwa","year":"2013","journal-title":"Korean Circ J"},{"issue":"1","key":"2023111414362172300_B9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000135646","article-title":"Neurological symptoms in aortic dissection: a challenge for neurologists","volume":"26","author":"Gaul","year":"2008","journal-title":"Cerebrovasc Dis"},{"issue":"7","key":"2023111414362172300_B10","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1001\/jama.283.7.897","article-title":"The International Registry of Acute Aortic Dissection (IRAD): new insights into an old disease","volume":"283","author":"Hagan","year":"2000","journal-title":"JAMA"},{"issue":"6","key":"2023111414362172300_B11","doi-asserted-by":"crossref","first-page":"582","DOI":"10.21037\/acs.2017.11.03","article-title":"Differences in manifestations of Marfan syndrome, Ehlers-Danlos syndrome, and Loeys-Dietz syndrome","volume":"6","author":"Meester","year":"2017","journal-title":"Ann Cardiothorac Surg"},{"issue":"1","key":"2023111414362172300_B12","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/0735-1097(94)90516-9","article-title":"Ebstein\u2019s anomaly: presentation and outcome from fetus to adult","volume":"23","author":"Celermajer","year":"1994","journal-title":"J Am Coll Cardiol"},{"key":"2023111414362172300_B13","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.ijporl.2018.10.026","article-title":"Prevalence of bifid uvula in primary school children","volume":"116","author":"Feka","year":"2019","journal-title":"Int J Pediatr Otorhinolaryngol"},{"issue":"3","key":"2023111414362172300_B14","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1016\/j.athoracsur.2015.05.071","article-title":"Total aortic replacement for a 9-year-old boy with loeys-dietz syndrome","volume":"101","author":"Inoue","year":"2016","journal-title":"Ann Thorac Surg"},{"issue":"2","key":"2023111414362172300_B15","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/j.athoracsur.2011.04.003","article-title":"Valve-sparing aortic root replacement in Loeys-Dietz syndrome","volume":"92","author":"Patel","year":"2011","journal-title":"Ann Thorac Surg"},{"issue":"5","key":"2023111414362172300_B16","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1002\/ajmg.a.61508","article-title":"Homozygous deletion of exons 2-7 within TGFB3 gene in a child with severe Loeys-Dietz syndrome and Marfan-like features","volume":"182","author":"M\u00e9garban\u00e9","year":"2020","journal-title":"Am J Med Genet A"},{"issue":"5","key":"2023111414362172300_B17","first-page":"E72","article-title":"ACC\/AHA guideline for the management of patients with valvular heart disease: a report of the American College of Cardiology\/American Heart Association Joint Committee on Clinical Practice Guidelines","volume":"143","author":"Otto","year":"2021","journal-title":"Circulation"},{"issue":"22","key":"2023111414362172300_B18","doi-asserted-by":"crossref","first-page":"e292","DOI":"10.1161\/CIR.0000000000000241","article-title":"Eligibility and disqualification recommendations for competitive athletes with cardiovascular abnormalities: Task Force 5: valvular heart disease: a scientific statement from the American Heart Association and American College of Cardiology","volume":"132","author":"Bonow","year":"2015","journal-title":"Circulation"},{"issue":"22","key":"2023111414362172300_B19","doi-asserted-by":"crossref","first-page":"e262","DOI":"10.1161\/CIR.0000000000000237","article-title":"Eligibility and disqualification recommendations for competitive athletes with cardiovascular abnormalities: Task Force 1: classification of sports: dynamic, static, and impact: a scientific statement from the American Heart Association and American College of Cardiology","volume":"132","author":"Levine","year":"2015","journal-title":"Circulation"}],"container-title":["Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/publications.aap.org\/pediatrics\/article-pdf\/doi\/10.1542\/peds.2022-057694\/1567035\/peds_2022057694.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/publications.aap.org\/pediatrics\/article-pdf\/doi\/10.1542\/peds.2022-057694\/1567035\/peds_2022057694.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,14]],"date-time":"2023-11-14T14:38:12Z","timestamp":1699972692000},"score":1,"resource":{"primary":{"URL":"https:\/\/publications.aap.org\/pediatrics\/article\/152\/2\/e2022057694\/192776\/Aortic-Dissection-in-a-Young-Patient-With"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,14]]},"references-count":19,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2023,7,14]]},"published-print":{"date-parts":[[2023,8,1]]}},"URL":"https:\/\/doi.org\/10.1542\/peds.2022-057694","relation":{},"ISSN":["0031-4005","1098-4275"],"issn-type":[{"value":"0031-4005","type":"print"},{"value":"1098-4275","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7,14]]},"article-number":"e2022057694"}}