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The therapeutic management of pediatric IBD has evolved by taking into account predictors of poor outcome, which justifies the upfront use of anti-tumor necrosis factor therapy for patients at high risk for complicated disease. In treating patients with IBD, biochemical or endoscopic remission, rather than clinical remission, is the therapeutic goal because intestinal inflammation often persists despite resolution of abdominal symptoms. Pediatric IBD comes with unique additional challenges, such as growth impairment, pubertal delay, the psychology of adolescence, and development of body image. Even after remission has been achieved, many patients with IBD continue to experience nonspecific symptoms like abdominal pain and fatigue. Transfer to adult care is a well-recognized risk for disease relapse, which highlights patient vulnerability and the need for a transition program that is continued by the adult-oriented IBD team. The general pediatrician is an invaluable link in integrating these challenges in the clinical care of patients with IBD and optimizing their outcomes. This state-of-the-art review aims to provide general pediatricians with an update on pediatric IBD to facilitate interactions with pediatric gastrointestinal specialists.<\/jats:p>","DOI":"10.1542\/peds.2022-058037","type":"journal-article","created":{"date-parts":[[2022,12,22]],"date-time":"2022-12-22T03:08:31Z","timestamp":1671678511000},"source":"Crossref","is-referenced-by-count":129,"title":["Pediatric Inflammatory Bowel Disease"],"prefix":"10.1542","volume":"151","author":[{"given":"Marleen","family":"Bouhuys","sequence":"first","affiliation":[{"name":"Department of Pediatric Gastroenterology, Hepatology and Nutrition, University of Groningen, University Medical Centre Groningen, Beatrix Children\u2019s Hospital, Groningen, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Willem S.","family":"Lexmond","sequence":"additional","affiliation":[{"name":"Department of Pediatric Gastroenterology, Hepatology and Nutrition, University of Groningen, University Medical Centre Groningen, Beatrix Children\u2019s Hospital, Groningen, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick F.","family":"van Rheenen","sequence":"additional","affiliation":[{"name":"Department of Pediatric Gastroenterology, Hepatology and Nutrition, University of Groningen, University Medical Centre Groningen, Beatrix Children\u2019s Hospital, Groningen, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"417","published-online":{"date-parts":[[2022,12,22]]},"reference":[{"key":"2023111013544674500_B1","doi-asserted-by":"crossref","first-page":"11779322211055285","DOI":"10.1177\/11779322211055285","article-title":"Genetic variants assessing Crohn\u2019s disease pattern in pediatric inflammatory bowel disease patients by a clinical exome survey. 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