{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T20:15:25Z","timestamp":1793996125745,"version":"4.8.0"},"reference-count":52,"publisher":"American Academy of Pediatrics (AAP)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,8,1]]},"abstract":"<jats:sec>\n                  <jats:title\/>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>OBJECTIVES<\/jats:title>\n                  <jats:p>Describe clinical and epidemiologic patterns of pediatric allergy using longitudinal electronic health records (EHRs) from a multistate consortium of US practices.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>Using the multistate Comparative Effectiveness Research through Collaborative Electronic Reporting EHR database, we defined a cohort of 218\u2009485 children (0\u201318 years) who were observed for \u22655 years between 1999 and 2020. Children with atopic dermatitis (AD), immunoglobulin E\u2013mediated food allergy (IgE-FA), asthma, allergic rhinitis (AR), and eosinophilic esophagitis (EoE) were identified using a combination of diagnosis codes and medication prescriptions. We determined age at diagnosis, cumulative incidence, and allergic comorbidity.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>Allergic disease cumulative (and peak age of) incidence was 10.3% (4 months) for AD, 4.0% (13 months) for IgE-FA, 20.1% (13 months) for asthma, 19.7% (26 months) for AR, and 0.11% (35 months) for EoE. The most diagnosed IgE-FAs were peanut (1.9%), egg (0.8%), and shellfish (0.6%). A total of 13.4% of children had \u22652 allergic conditions, and respiratory allergies (ie, asthma, AR) were commonly comorbid with each other, and with other allergic conditions.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>We detail pediatric allergy patterns using longitudinal, health care provider-based data from EHR systems across multiple US states and varied pediatric practice types. Our results support the population-level allergic march progression and indicate high rates of comorbidity among children with food and respiratory allergies.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1542\/peds.2022-060531","type":"journal-article","created":{"date-parts":[[2023,7,25]],"date-time":"2023-07-25T08:18:00Z","timestamp":1690273080000},"source":"Crossref","is-referenced-by-count":46,"title":["Patterns in the Development of Pediatric Allergy"],"prefix":"10.1542","volume":"152","author":[{"given":"Stanislaw J.","family":"Gabryszewski","sequence":"first","affiliation":[{"name":"aDivision of Allergy and Immunology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesse","family":"Dudley","sequence":"additional","affiliation":[{"name":"bClinical Futures, Department of Biomedical and Health Informatics, Department of Pediatrics, Children\u2019s Hospital of Philadelphia, Philadelphia, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Di","family":"Shu","sequence":"additional","affiliation":[{"name":"bClinical Futures, Department of Biomedical and Health Informatics, Department of Pediatrics, Children\u2019s Hospital of Philadelphia, Philadelphia, Pennsylvania"},{"name":"cDepartment of Biostatistics, Epidemiology and Informatics"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer A.","family":"Faerber","sequence":"additional","affiliation":[{"name":"bClinical Futures, Department of Biomedical and Health Informatics, Department of Pediatrics, Children\u2019s Hospital of Philadelphia, Philadelphia, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert W.","family":"Grundmeier","sequence":"additional","affiliation":[{"name":"bClinical Futures, Department of Biomedical and Health Informatics, Department of Pediatrics, Children\u2019s Hospital of Philadelphia, Philadelphia, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander G.","family":"Fiks","sequence":"additional","affiliation":[{"name":"bClinical Futures, Department of Biomedical and Health Informatics, Department of Pediatrics, Children\u2019s Hospital of Philadelphia, Philadelphia, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Hill","sequence":"additional","affiliation":[{"name":"aDivision of Allergy and Immunology"},{"name":"dDepartment of Pediatrics and Institute for Immunology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"417","published-online":{"date-parts":[[2023,7,25]]},"reference":[{"issue":"11","key":"2023111414355393200_B1","doi-asserted-by":"crossref","first-page":"100591","DOI":"10.1016\/j.waojou.2021.100591","article-title":"Allergic diseases in infancy: I - 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