{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T13:13:33Z","timestamp":1791983613186,"version":"4.4.0"},"reference-count":22,"publisher":"American Academy of Pediatrics (AAP)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,7,1]]},"abstract":"<jats:sec>\n                  <jats:title>OBJECTIVES<\/jats:title>\n                  <jats:p>Although children who survive sepsis are at risk for readmission, identification of patient-level variables associated with readmission has been limited by administrative datasets. We determined frequency and cause of readmission within 90 days of discharge and identified patient-level variables associated with readmission using a large, electronic health record-based registry.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>This retrospective observational study included 3464 patients treated for sepsis or septic shock between January 2011 and December 2018 who survived to discharge at a single academic children\u2019s hospital. We determined frequency and cause of readmission through 90 days post-discharge and identified patient-level variables associated with readmission. Readmission was defined as inpatient treatment within 90 days post-discharge from a prior sepsis hospitalization. Outcomes were frequency of and reasons for 7-, 30-, and 90-day (primary) readmission. Patient variables were tested for independent associations with readmission using multivariable logistic regression.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>Following index sepsis hospitalization, frequency of readmission at 7, 30, and 90 days was 7% (95% confidence interval 6%\u20138%), 20% (18%\u201321%), and 33% (31%\u201334%). Variables independently associated with 90-day readmission were age \u2264 1 year, chronic comorbid conditions, lower hemoglobin and higher blood urea nitrogen at sepsis recognition, and persistently low white blood cell count \u2264 2 thous\/\u00b5L. These variables explained only a small proportion of overall risk (pseudo-R2 range 0.05\u20130.13) and had moderate predictive validity (area under the receiver operating curve range 0.67\u20130.72) for readmission.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>Children who survive sepsis were frequently readmitted, most often for infections. Risk for readmission was only partly indicated by patient-level variables.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1542\/peds.2022-060819","type":"journal-article","created":{"date-parts":[[2023,6,27]],"date-time":"2023-06-27T08:15:10Z","timestamp":1687853710000},"source":"Crossref","is-referenced-by-count":10,"title":["Frequency of and Risk Factors Associated With Hospital Readmission After Sepsis"],"prefix":"10.1542","volume":"152","author":[{"given":"Hannah S.","family":"Dashefsky","sequence":"first","affiliation":[{"name":"aDepartments of Anesthesiology and Critical Care"},{"name":"bPediatric Sepsis Program"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyan","family":"Liu","sequence":"additional","affiliation":[{"name":"cData Science and Biostatistics Unit, Department of Biomedical and Health Informatics, Children\u2019s Hospital of Philadelphia, Philadelphia, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katie","family":"Hayes","sequence":"additional","affiliation":[{"name":"bPediatric Sepsis Program"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather","family":"Griffis","sequence":"additional","affiliation":[{"name":"cData Science and Biostatistics Unit, Department of Biomedical and Health Informatics, Children\u2019s Hospital of Philadelphia, Philadelphia, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa","family":"Vaughan","sequence":"additional","affiliation":[{"name":"aDepartments of Anesthesiology and Critical Care"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianne","family":"Chilutti","sequence":"additional","affiliation":[{"name":"dBiomedical and Health Informatics"},{"name":"eArcus Program, Children\u2019s Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran","family":"Balamuth","sequence":"additional","affiliation":[{"name":"bPediatric Sepsis Program"},{"name":"fPediatrics"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah R.","family":"Stinson","sequence":"additional","affiliation":[{"name":"aDepartments of Anesthesiology and Critical Care"},{"name":"bPediatric Sepsis Program"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie C.","family":"Fitzgerald","sequence":"additional","affiliation":[{"name":"aDepartments of Anesthesiology and Critical Care"},{"name":"bPediatric Sepsis Program"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin F.","family":"Carlton","sequence":"additional","affiliation":[{"name":"gDivision of Critical Care Medicine, Department of Pediatrics, University of Michigan, Ann Arbor, Michigan"},{"name":"hSusan B. Meister Child Health Evaluation and Research Center, Department of Pediatrics, University of Michigan, Ann Arbor, Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott L.","family":"Weiss","sequence":"additional","affiliation":[{"name":"aDepartments of Anesthesiology and Critical Care"},{"name":"bPediatric Sepsis Program"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"417","published-online":{"date-parts":[[2023,6,27]]},"reference":[{"issue":"9","key":"2023111414261939200_B1","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1097\/PCC.0000000000000225","article-title":"Pediatric severe sepsis in U.S. children's hospitals","volume":"15","author":"Balamuth","year":"2014","journal-title":"Pediatr Crit Care Med"},{"issue":"3","key":"2023111414261939200_B2","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S2213-2600(18)30063-8","article-title":"The global burden of paediatric and neonatal sepsis: a systematic review","volume":"6","author":"Fleischmann-Struzek","year":"2018","journal-title":"Lancet Respir Med"},{"issue":"9","key":"2023111414261939200_B3","first-page":"828","article-title":"Pediatric severe sepsis: current trends and outcomes from the Pediatric Health Information Systems database. 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