{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T06:26:55Z","timestamp":1771482415306,"version":"3.50.1"},"reference-count":28,"publisher":"American Academy of Pediatrics (AAP)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,8,1]]},"abstract":"<jats:sec>\n                  <jats:title\/>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>BACKGROUND AND OBJECTIVES<\/jats:title>\n                  <jats:p>Former premature infants with bronchopulmonary dysplasia (BPD) are at risk for hypoxemia during air travel, but it is unclear until what age. We aimed to determine pass rates for high altitude simulation testing (HAST) by age in children with BPD and identify risks for failure.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>Retrospective, observational analysis of HAST in children with BPD at Boston Children\u2019s Hospital, using interval censoring to estimate the time-to-event curve of first pass. Curves were stratified by neonatal risk factors. Pass was considered lowest Spo2 \u2265 90%, or \u226594% for subjects with ongoing pulmonary hypertension (PH).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>Ninety four HAST studies were analyzed from 63 BPD subjects; 59 studies (63%) were passed. At 3 months corrected gestational age (CGA), 50% of subjects had passed; at 6 months CGA, 67% has passed; at 12 and 18 months CGA, 72% had passed; and at 24 months CGA, 85% had passed. Neonatal factors associated with delayed time-to-pass included postnatal corticosteroid use, respiratory support at NICU discharge, and tracheostomy. BPD infants who did not require respiratory support at 36 weeks were likely to pass (91%) at 6 months CGA. At 24 months, children least likely to pass included those with a history of PH (63%) and those discharged from the NICU with oxygen or respiratory support (71%).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>Children with BPD on respiratory support at 36 weeks should be considered for preflight hypoxemia challenges through at least 24 months CGA, and longer if they had PH or went home from NICU on respiratory support.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1542\/peds.2022-061001","type":"journal-article","created":{"date-parts":[[2023,7,28]],"date-time":"2023-07-28T08:18:11Z","timestamp":1690532291000},"source":"Crossref","is-referenced-by-count":7,"title":["Pre-Flight Hypoxemia Challenge Testing in Bronchopulmonary Dysplasia"],"prefix":"10.1542","volume":"152","author":[{"given":"Jonathan C.","family":"Levin","sequence":"first","affiliation":[{"name":"aDivision of Newborn Medicine, Boston Children's Hospital, Boston, Massachusetts"},{"name":"bDivision of Pulmonary Medicine, Boston Children\u2019s Hospital, Boston, Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine A.","family":"Sheils","sequence":"additional","affiliation":[{"name":"bDivision of Pulmonary Medicine, Boston Children\u2019s Hospital, Boston, Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lystra P.","family":"Hayden","sequence":"additional","affiliation":[{"name":"bDivision of Pulmonary Medicine, Boston Children\u2019s Hospital, Boston, Massachusetts"},{"name":"cChanning Division of Network Medicine, Brigham and Women\u2019s Hospital, Boston, 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