{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T22:10:55Z","timestamp":1793139055414,"version":"4.5.0"},"reference-count":40,"publisher":"American Academy of Pediatrics (AAP)","issue":"Supplement 2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,9,1]]},"abstract":"<jats:p>Children with inherited and\/or acquired respiratory disorders often arrive in adolescence and adulthood with diminished lung function that might have been detected and prevented had better mechanisms been available to identify and to assess progression of disease. Fortunately, advances in genetic assessments, low-cost diagnostics, and minimally- invasive novel biomarkers are being developed to detect and to treat respiratory diseases before they give rise to loss of life or lung function. This paper summarizes the Developing Biomarkers for Pulmonary Health sessions of the National Heart, Lung, and Blood Institute- sponsored 2021 Defining and Promoting Pediatric Pulmonary Health workshop. These sessions discussed genetic testing, pulse oximetry, exhaled nitric oxide, and novel biomarkers related to childhood lung diseases.<\/jats:p>","DOI":"10.1542\/peds.2023-062292c","type":"journal-article","created":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T12:47:01Z","timestamp":1693572421000},"source":"Crossref","is-referenced-by-count":3,"title":["Defining and Promoting Pediatric Pulmonary Health: Developing Biomarkers for Pulmonary Health"],"prefix":"10.1542","volume":"152","author":[{"given":"Michael D.","family":"Davis","sequence":"first","affiliation":[{"name":"aWells Center for Pediatric Research and Division of Pulmonology, Allergy, and Sleep Medicine, Riley Hospital for Children at Indiana University, Indianapolis, Indiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joe G.","family":"Zein","sequence":"additional","affiliation":[{"name":"bDepartment of Pulmonary Medicine, Respiratory Institute and Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Carraro","sequence":"additional","affiliation":[{"name":"cUnit of Pediatric Allergy and Respiratory Medicine, Women\u2019s and Children\u2019s Health Department, University of Padova, Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Gaston","sequence":"additional","affiliation":[{"name":"aWells Center for Pediatric Research and Division of Pulmonology, Allergy, and Sleep Medicine, Riley Hospital for Children at Indiana University, Indianapolis, Indiana"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"417","published-online":{"date-parts":[[2023,9,1]]},"reference":[{"issue":"12","key":"2023090112455807200_B1","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1164\/rccm.200605-642ST","article-title":"An official American Thoracic Society\/European Respiratory Society statement: pulmonary function testing in preschool children","volume":"175","author":"Beydon","year":"2007","journal-title":"Am J Respir Crit Care Med"},{"issue":"11","key":"2023090112455807200_B2","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1164\/rccm.200408-1141ST","article-title":"ATS\/ERS statement: raised volume forced expirations in infants: guidelines for current practice","volume":"172","author":"American Thoracic Society","year":"2005","journal-title":"Am J Respir Crit Care Med"},{"issue":"2","key":"2023090112455807200_B3","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/S2213-2600(12)70057-7","article-title":"A new era in the treatment of cystic fibrosis: correction of the underlying CFTR defect","volume":"1","author":"Boyle","year":"2013","journal-title":"Lancet Respir Med"},{"key":"2023090112455807200_B4","first-page":"18","article-title":"Genetics and biology of primary ciliary dyskinesia","volume":"18","author":"Horani","year":"2016","journal-title":"Paediatr Respir Rev"},{"issue":"1","key":"2023090112455807200_B5","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1111\/all.12063","article-title":"Asthma severity in childhood and metabolomic profiling of breath condensate","volume":"68","author":"Carraro","year":"2013","journal-title":"Allergy"},{"key":"2023090112455807200_B6","first-page":"37","article-title":"Exhaled breath testing - a tool for the clinician and researcher","volume":"29","author":"Davis","year":"2019","journal-title":"Paediatr Respir Rev"},{"issue":"2","key":"2023090112455807200_B7","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1164\/rccm.201408-1537OC","article-title":"Exhaled biomarkers and gene expression at preschool age improve asthma prediction at 6 years of age","volume":"191","author":"Klaassen","year":"2015","journal-title":"Am J Respir Crit Care Med"},{"issue":"1","key":"2023090112455807200_B8","doi-asserted-by":"crossref","first-page":"e47","DOI":"10.1016\/S2214-109X(18)30408-X","article-title":"Global, regional, and national estimates of pneumonia morbidity and mortality in children younger than 5 years between 2000 and 2015: a systematic analysis","volume":"7","author":"McAllister","year":"2019","journal-title":"Lancet Glob Health"},{"issue":"7580","key":"2023090112455807200_B9","doi-asserted-by":"crossref","first-page":"S53","DOI":"10.1038\/nature16043","article-title":"Evaluating the impact of pulse oximetry on childhood pneumonia mortality in resource-poor settings","volume":"528","author":"Floyd","year":"2015","journal-title":"Nature"},{"issue":"4","key":"2023090112455807200_B10","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1097\/SLA.0b013e3182777fa4","article-title":"Implementation of the World Health Organization surgical safety checklist, including introduction of pulse oximetry, in a resource-limited setting","volume":"257","author":"Kwok","year":"2013","journal-title":"Ann Surg"},{"key":"2023090112455807200_B11","unstructured":"CFTR2\n          . The clinical and functional translation of CFTR. Available at: https:\/\/cftr2.org\/. 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