{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,11]],"date-time":"2026-11-11T01:57:57Z","timestamp":1794362277817,"version":"4.9.0"},"reference-count":27,"publisher":"American Academy of Pediatrics (AAP)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,3,1]]},"abstract":"\n \n <\/jats:sec>\n \n BACKGROUND<\/jats:title>\n Respiratory syncytial virus (RSV) is the leading cause of hospitalization in US infants. Accurate estimates of severe RSV disease inform policy decisions for RSV prevention.<\/jats:p>\n <\/jats:sec>\n \n METHODS<\/jats:title>\n We conducted prospective surveillance for children &lt;5 years old with acute respiratory illness from 2016 to 2020 at 7 pediatric hospitals. We interviewed parents, reviewed medical records, and tested midturbinate nasal \u00b1 throat swabs by reverse transcription polymerase chain reaction for RSV and other respiratory viruses. We describe characteristics of children hospitalized with RSV, risk factors for ICU admission, and estimate RSV-associated hospitalization rates.<\/jats:p>\n <\/jats:sec>\n \n RESULTS<\/jats:title>\n Among 13\u2009524 acute respiratory illness inpatients &lt;5 years old, 4243 (31.4%) were RSV-positive; 2751 (64.8%) of RSV-positive children had no underlying condition or history of prematurity. The average annual RSV-associated hospitalization rate was 4.0 (95% confidence interval [CI]: 3.8\u20134.1) per 1000 children &lt;5 years, was highest among children 0 to 2 months old (23.8 [95% CI: 22.5\u201325.2] per 1000) and decreased with increasing age. Higher RSV-associated hospitalization rates were found in premature versus term children (rate ratio = 1.95 [95% CI: 1.76\u20132.11]). Risk factors for ICU admission among RSV-positive inpatients included: age 0 to 2 and 3 to 5 months (adjusted odds ratio [aOR] = 1.97 [95% CI: 1.54\u20132.52] and aOR = 1.56 [95% CI: 1.18\u20132.06], respectively, compared with 24\u201359 months), prematurity (aOR = 1.32 [95% CI: 1.08\u20131.60]) and comorbid conditions (aOR = 1.35 [95% CI: 1.10\u20131.66]).<\/jats:p>\n <\/jats:sec>\n \n CONCLUSIONS<\/jats:title>\n Younger infants and premature children experienced the highest rates of RSV-associated hospitalization and had increased risk of ICU admission. RSV prevention products are needed to reduce RSV-associated morbidity in young infants.<\/jats:p>\n <\/jats:sec>","DOI":"10.1542\/peds.2023-062574","type":"journal-article","created":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T08:07:05Z","timestamp":1706774825000},"source":"Crossref","is-referenced-by-count":89,"title":["Respiratory Syncytial Virus-Associated Hospitalizations Among Children &lt;5 Years Old: 2016 to 2020"],"prefix":"10.1542","volume":"153","author":[{"given":"Aaron T.","family":"Curns","sequence":"first","affiliation":[{"name":"aCenters for Disease Control and Prevention, Atlanta, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Rha","sequence":"additional","affiliation":[{"name":"aCenters for Disease Control and Prevention, Atlanta, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joana Y.","family":"Lively","sequence":"additional","affiliation":[{"name":"aCenters for Disease Control and 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Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura S.","family":"Stewart","sequence":"additional","affiliation":[{"name":"eVanderbilt University Medical Center, Nashville, Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Schlaudecker","sequence":"additional","affiliation":[{"name":"fDepartment of Pediatrics, University of Cincinnati, Division of Infectious Diseases, Cincinnati Children\u2019s Hospital Medical Center, Cincinnati, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter G.","family":"Szilagyi","sequence":"additional","affiliation":[{"name":"lUCLA Mattel Children\u2019s Hospital, University of California at Los Angeles, Los Angeles, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eileen J.","family":"Klein","sequence":"additional","affiliation":[{"name":"cSeattle Children\u2019s Hospital, Seattle, 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