{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T01:15:22Z","timestamp":1785460522461,"version":"3.56.0"},"reference-count":12,"publisher":"American Academy of Pediatrics (AAP)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,3,1]]},"abstract":"<jats:p>Congenital kidney failure not only affects the homeostatic functions of the kidney, but also affects neonatal respiratory integrity. Until recently, extracorporeal membrane oxygenation (ECMO) support was not used in this population because the need for ECMO clearly established nonviability. Since 2016, 31 neonates have been admitted to the NICU at Children\u2019s of Alabama with congenital kidney failure. Five patients were placed on ECMO for severe respiratory distress unresponsive to conventional interventions. We evaluated neonates with congenital kidney failure and pulmonary hypoplasia\/hypertension refractory to conventional therapies who received ECMO support within the first 9 postnatal days. We describe the pre and postnatal diagnoses, ECMO course details, dialysis modalities, complications, procedures, and long-term outcomes of these patients. All 5 patients received kidney support therapy by postnatal day 7. Diagnoses included posterior urethral valves, bilateral renal dysplasia, and autosomal recessive polycystic kidney disease. Gestational age ranged from 35.6 to 37.1 weeks. Birth weight ranged from 2740 to 3140 g. Days on ECMO ranged from 4 to 23. Four survived and are living today. Pulmonary hypertension resolved in surviving patients. Three surviving patients require no oxygen support, and 1 patient requires nocturnal oxygen. Three survivors received a kidney transplant, and 1 awaits transplant evaluation. Patients with congenital kidney failure with severe pulmonary hypoplasia\/pulmonary hypertension no longer warrant a reflexive assignment of nonviability. Meticulous ECMO, respiratory, nutritional, and kidney support therapies may achieve a favorable long-term outcome. Further investigation of strategies for optimal outcome is needed.<\/jats:p>","DOI":"10.1542\/peds.2023-062717","type":"journal-article","created":{"date-parts":[[2024,2,2]],"date-time":"2024-02-02T08:08:00Z","timestamp":1706861280000},"source":"Crossref","is-referenced-by-count":10,"title":["Survival of Infants With Severe Congenital Kidney Disease After ECMO and Kidney Support Therapy"],"prefix":"10.1542","volume":"153","author":[{"given":"Kara","family":"Short","sequence":"first","affiliation":[{"name":"aPediatric and Infant Center for Acute Nephrology at Children\u2019s of Alabama"},{"name":"bChildren's of Alabama, Birmingham, Alabama"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martha","family":"McBride","sequence":"additional","affiliation":[{"name":"bChildren's of Alabama, Birmingham, Alabama"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"Anderson","sequence":"additional","affiliation":[{"name":"cDepartment of Surgery, Division of Pediatric Surgery, University of Alabama at Birmingham"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Miller","sequence":"additional","affiliation":[{"name":"bChildren's of Alabama, Birmingham, Alabama"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daryl","family":"Ingram","sequence":"additional","affiliation":[{"name":"aPediatric and Infant Center for Acute Nephrology at Children\u2019s of Alabama"},{"name":"bChildren's of Alabama, Birmingham, Alabama"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carl","family":"Coghill","sequence":"additional","affiliation":[{"name":"dDepartment of Neonatology, University of Alabama at Birmingham"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Sims","sequence":"additional","affiliation":[{"name":"dDepartment of Neonatology, University of Alabama at Birmingham"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Askenazi","sequence":"additional","affiliation":[{"name":"aPediatric and Infant Center for Acute Nephrology at Children\u2019s of Alabama"},{"name":"eDivision of Pediatric Nephrology, University of Alabama at Birmingham, Birmingham, Alabama"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"417","published-online":{"date-parts":[[2024,2,2]]},"reference":[{"issue":"9","key":"2024030103475709300_B1","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1136\/archdischild-2015-309784","article-title":"The outcome of antenatal ultrasound diagnosed anomalies of the kidney and urinary tract in a large Danish birth cohort","volume":"101","author":"Andr\u00e9s-Jensen","year":"2016","journal-title":"Arch Dis Child"},{"issue":"6","key":"2024030103475709300_B2","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1007\/s00467-011-2098-0","article-title":"Ultrasound mass screening 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