{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T17:37:38Z","timestamp":1793813858798,"version":"4.6.1"},"reference-count":43,"publisher":"American Academy of Pediatrics (AAP)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,12,1]]},"abstract":"<jats:sec>\n                    <jats:title>OBJECTIVES<\/jats:title>\n                    <jats:p>To assess the prevalence of residual cardiovascular pathology by cardiac MRI (CMR), ambulatory rhythm monitoring, and cardiopulmonary exercise testing (CPET) in patients \u223c6 months after multisystem inflammatory disease in children (MIS-C).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>Patients seen for MIS-C follow-up were referred for CMR, ambulatory rhythm monitoring, and CPET \u223c6 months after illness. Patients were included if they had \u22651 follow-up study performed by the time of data collection. MIS-C was diagnosed on the basis of the Centers for Disease Control and Prevention criteria. Myocardial injury during acute illness was defined as serum Troponin-I level &amp;gt;0.05 ng\/mL or diminished left ventricular systolic function on echocardiogram.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Sixty-nine of 153 patients seen for MIS-C follow-up had \u22651 follow-up cardiac study between October 2020\u2013June 2022. Thirty-seven (54%) had evidence of myocardial injury during acute illness. Of these, 12 of 26 (46%) had \u22651 abnormality on CMR, 4 of 33 (12%) had abnormal ambulatory rhythm monitor results, and 18 of 22 (82%) had reduced functional capacity on CPET. Of the 37 patients without apparent myocardial injury, 11 of 21 (52%) had \u22651 abnormality on CMR, 1 of 24 (4%) had an abnormal ambulatory rhythm monitor result, and 11 of 15 (73%) had reduced functional capacity on CPET. The prevalence of abnormal findings was not statistically significantly different between groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>The high prevalence of abnormal findings on follow-up cardiac studies and lack of significant difference between patients with and without apparent myocardial injury during hospitalization suggests that all patients treated for MIS-C warrant cardiology follow-up.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1542\/peds.2023-063002","type":"journal-article","created":{"date-parts":[[2023,11,15]],"date-time":"2023-11-15T03:15:56Z","timestamp":1700018156000},"source":"Crossref","is-referenced-by-count":14,"title":["Cardiovascular Follow-up of Patients Treated for MIS-C"],"prefix":"10.1542","volume":"152","author":[{"given":"Dayna","family":"Zimmerman","sequence":"first","affiliation":[{"name":"aDivision of 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