{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:00:04Z","timestamp":1753887604705,"version":"3.41.2"},"reference-count":18,"publisher":"American Academy of Pediatrics (AAP)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,4,1]]},"abstract":"<jats:p>Acquired hemophilia is caused by acquired autoantibodies to 1 of the factors of the coagulation cascade, usually factor VIII or IX, and is an exceedingly rare phenomenon in children. The finding of an acquired factor VIII inhibitor in a pediatric patient with idiopathic multicentric Castleman disease has never been reported. Patients with acquired hemophilia can have life-threatening bleeds that are refractory to blood product support, requiring bypassing agents to manage bleeding symptoms. We present the novel finding of acquired hemophilia resulting from an autoantibody to factor VIII in a pediatric patient with idiopathic multicentric Castleman disease and discuss the optimal management of bleeding in a patient with acquired hemophilia.<\/jats:p>","DOI":"10.1542\/peds.2023-063168","type":"journal-article","created":{"date-parts":[[2024,3,21]],"date-time":"2024-03-21T08:06:05Z","timestamp":1711008365000},"source":"Crossref","is-referenced-by-count":0,"title":["Acquired Hemophilia: A Rare Complication of Pediatric Idiopathic Multicentric Castleman Disease"],"prefix":"10.1542","volume":"153","author":[{"given":"Lauren E.","family":"Appell","sequence":"first","affiliation":[{"name":"aDepartment of Pediatrics, Division of Pediatric Hematology\/Oncology"},{"name":"bArkansas Children\u2019s Hospital, Little Rock Arkansas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joana M.","family":"Mack","sequence":"additional","affiliation":[{"name":"aDepartment of Pediatrics, Division of Pediatric Hematology\/Oncology"},{"name":"bArkansas Children\u2019s Hospital, Little Rock Arkansas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason E.","family":"Farrar","sequence":"additional","affiliation":[{"name":"aDepartment of Pediatrics, Division of Pediatric Hematology\/Oncology"},{"name":"bArkansas Children\u2019s Hospital, Little Rock Arkansas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sydney N.","family":"Roper","sequence":"additional","affiliation":[{"name":"cCollege of Medicine"},{"name":"dDepartment of Medicine & Pediatrics, University of Tennessee Health Science Center, Memphis, Tennessee"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew R.","family":"Savage","sequence":"additional","affiliation":[{"name":"cCollege of Medicine"},{"name":"eDepartment of Family Medicine, Baptist Health-University of Arkansas for Medical Sciences, Little Rock, Arkansas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soumya","family":"Pandey","sequence":"additional","affiliation":[{"name":"fDepartment of Pathology, University of Arkansas for Medical Sciences, Little Rock, Arkansas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shelley E.","family":"Crary","sequence":"additional","affiliation":[{"name":"aDepartment of Pediatrics, Division of Pediatric Hematology\/Oncology"},{"name":"bArkansas Children\u2019s Hospital, Little Rock Arkansas"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"417","published-online":{"date-parts":[[2024,3,21]]},"reference":[{"issue":"4","key":"2024040102521022900_B1","doi-asserted-by":"crossref","first-page":"e163","DOI":"10.1016\/S2352-3026(16)00006-5","article-title":"Idiopathic multicentric Castleman\u2019s disease: a systematic literature review","volume":"3","author":"Liu","year":"2016","journal-title":"Lancet Haematol"},{"key":"2024040102521022900_B2","first-page":"1","article-title":"TAFRO syndrome: a case report and review of the literature","volume":"10","author":"Hou","year":"2017","journal-title":"Hum Pathol (N Y)"},{"issue":"2","key":"2024040102521022900_B3","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1111\/j.1365-2141.1972.tb03468.x","article-title":"The mode of action of antibodies which destroy factor VIII. 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