{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T19:58:14Z","timestamp":1793995094046,"version":"4.8.0"},"reference-count":33,"publisher":"American Academy of Pediatrics (AAP)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,8,1]]},"abstract":"<jats:sec>\n                    <jats:title>OBJECTIVES<\/jats:title>\n                    <jats:p>This study described disease characteristics and long-term outcomes in patients diagnosed with very early onset inflammatory bowel disease (VEOIBD) (diagnosed before 6 years of age) and infantile-IBD (before 2 years).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>Cases from 21 centers worldwide diagnosed with VEOIBD (2008\u20132018), with minimum 2 years of follow-up, were retrospectively reviewed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>The cohort included 243 patients (52% males, median follow-up of 5.8 [range 2\u221218] years, including 69 [28%]) with infantile-IBD. IBD subtypes included Crohn\u2019s disease (CD), ulcerative colitis (UC), or IBD-unclassified (IBDU) in 30%, 59%, and 11%, respectively. Among patients with CD, 94% had colonic involvement, and among patients with UC\/IBDU, 75% had pancolitis. Patients with infantile-IBD presented with higher rates of IBDU, lower hemoglobin and albumin levels, and higher C-reactive protein, and had lower response rates to first-induction therapy and corticosteroids therapy (P &amp;lt; .05 for all). Colectomy and diversion surgeries were performed in 11% and 4%, respectively, with no significant differences between age groups. Corticosteroid-free remission rates were 74% and 78% after 3 and 5 years, respectively, and 86% at end of follow-up. Genetic testing was performed in 96 (40%) patients. Among tested population, 15 (16%) were identified with monogenic disease. This group demonstrated lower response rates to induction therapies, higher rates of surgical intervention, and higher rates of major infections (P &amp;lt; .05 for all).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>Patients with VEOIBD, including infantile-IBD, exhibit low rate of complications and surgical interventions at the long term. Patients with monogenic IBD are at risk for more severe disease course.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1542\/peds.2023-064546","type":"journal-article","created":{"date-parts":[[2024,7,17]],"date-time":"2024-07-17T04:05:41Z","timestamp":1721189141000},"source":"Crossref","is-referenced-by-count":22,"title":["Infantile and Very Early Onset Inflammatory Bowel Disease: A Multicenter Study"],"prefix":"10.1542","volume":"154","author":[{"given":"Anat","family":"Guz-Mark","sequence":"first","affiliation":[{"name":"aInstitute of Gastroenterology, Nutrition and Liver Diseases, Schneider Children\u2019s Medical Center of Israel, Petach Tikva, Tel-Aviv University, Tel-Aviv, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Aloi","sequence":"additional","affiliation":[{"name":"bPediatric and Gastroenterology Unit, Sapienza University of Rome-Umberto I Hospital, Rome, 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