{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T12:40:08Z","timestamp":1793796008321,"version":"4.6.1"},"reference-count":83,"publisher":"American Academy of Pediatrics (AAP)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,5,1]]},"abstract":"<jats:sec>\n                  <jats:title\/>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title\/>\n                  <jats:p>A multidisciplinary committee developed evidence-based guidelines for the management of cystic fibrosis transmembrane conductance regulator-related metabolic syndrome\/cystic fibrosis screen-positive, inconclusive diagnosis (CRMS\/CFSPID). A total of 24 patient, intervention, comparison, and outcome questions were generated based on surveys sent to people with CRMS\/CFSPID and clinicians caring for these individuals, previous recommendations, and expert committee input. Four a priori working groups (genetic testing, monitoring, treatment, and psychosocial\/communication issues) were used to provide structure to the committee. A systematic review of the evidence was conducted, and found numerous case series and cohort studies, but no randomized clinical trials. A total of 30 recommendations were graded using the US Preventive Services Task Force methodology. Recommendations that received \u226580% consensus among the entire committee were approved. The resulting recommendations were of moderate to low certainty for the majority of the statements because of the low quality of the evidence. Highlights of the recommendations include thorough evaluation with genetic sequencing, deletion\/duplication analysis if &amp;lt;2 disease-causing variants were noted in newborn screening; repeat sweat testing until at least age 8 but limiting further laboratory testing, including microbiology, radiology, and pulmonary function testing; minimal use of medications, which when suggested, should lead to shared decision-making with families; and providing communication with emphasis on social determinants of health and shared decision-making to minimize barriers which may affect processing and understanding of this complex designation. Future research will be needed regarding medication use, antibiotic therapy, and the use of chest imaging for monitoring the development of lung disease.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1542\/peds.2023-064657","type":"journal-article","created":{"date-parts":[[2024,4,5]],"date-time":"2024-04-05T08:10:29Z","timestamp":1712304629000},"source":"Crossref","is-referenced-by-count":35,"title":["Cystic Fibrosis Foundation Evidence-Based Guideline for the Management of CRMS\/CFSPID"],"prefix":"10.1542","volume":"153","author":[{"given":"Deanna M.","family":"Green","sequence":"first","affiliation":[{"name":"aJohns Hopkins All Children\u2019s Hospital, St Petersburg, Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Lahiri","sequence":"additional","affiliation":[{"name":"bUniversity of Vermont Children\u2019s Hospital, Burlington, Vermont"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen S.","family":"Raraigh","sequence":"additional","affiliation":[{"name":"cJohns Hopkins University School of Medicine, Baltimore, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fadel","family":"Ruiz","sequence":"additional","affiliation":[{"name":"dBaylor College of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacquelyn","family":"Spano","sequence":"additional","affiliation":[{"name":"eStanford University School of Medicine, Stanford, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Antos","sequence":"additional","affiliation":[{"name":"fMedical College of Wisconsin, Children\u2019s Wisconsin, Milwaukee, Wisconsin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynn","family":"Bonitz","sequence":"additional","affiliation":[{"name":"gCohen Children\u2019s Medical Center of NY\/Northwell Health, New Hyde Park, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lillian","family":"Christon","sequence":"additional","affiliation":[{"name":"hMedical University of South Carolina, Charleston, South Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myrtha","family":"Gregoire-Bottex","sequence":"additional","affiliation":[{"name":"iAdvanced Pediatric Pulmonology, Pllc, Miramar, Florida"},{"name":"jMemorial Health Network, Hollywood, Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaime E.","family":"Hale","sequence":"additional","affiliation":[{"name":"kUniversity of Massachusetts Chan Medical School, Worcester, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elinor","family":"Langfelder-Schwind","sequence":"additional","affiliation":[{"name":"lLenox Hill Hospital\/Northwell Health, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1lvaro","family":"La Parra Perez","sequence":"additional","affiliation":[{"name":"mJohn B. 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