{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T04:43:43Z","timestamp":1792039423099,"version":"4.4.0"},"reference-count":48,"publisher":"American Academy of Pediatrics (AAP)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,10,1]]},"abstract":"<jats:sec>\n                  <jats:title>OBJECTIVES<\/jats:title>\n                  <jats:p>To evaluate the developmental trajectory of key cognitive, social, and emotional features in girls with fragile X syndrome (FXS).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>This longitudinal, parallel cohort study collected data between January 2018 and December 2022. Participants were evaluated 3 times with \u223c12\u201318 months between visits. Participants included 65 girls with FXS, 6 to 16 years, and 52 age- and developmentally-matched girls without FXS. Participants\u2019 scores from direct assessment and caregiver report evaluated 3 cognitive domains (verbal abilities, nonverbal abilities, executive function) and 4 social\u2013emotional domains (depression, general anxiety, social behavior, and social anxiety).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>Participants included 117 girls (mean [M] [SD] age at study entry: FXS M = 10.59 [3.00]; comparison M = 10.45 [2.40])). Omnibus tests showed 4 domains with significant group differences: Verbal (P &amp;lt; .0001, eg, Differential Abilities Scale-II(DAS-II), Picture Vocabulary (\u22126.25 [1.87])), nonverbal (P &amp;lt; .0001, eg, Kaufman Test of Educational Achievement, Third Edition, Brief Form, Math (\u22128.56 [2.90])), executive function (P &amp;lt; .0001, eg, NIH Toolbox List Sorting (\u22126.26 [1.48])), and social anxiety (P &amp;lt; .03, eg, Anxiety, Depression, and Mood Scale (ADAMS) Social Avoidance (1.50 [0.65])). Three domains had significant group by age interaction: Verbal (P &amp;lt; .04, eg, DAS-II, Word Definitions (\u22121.33 [0.55])), social behavior (P &amp;lt; .01, eg, Social Responsiveness Scale-2 Social Communication (1.57 [0.51])), and social anxiety (P &amp;lt; .01, eg, ADAMS Social Avoidance (0.46 [0.19])).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>These findings support the development of early, disorder specific interventions for girls with FXS targeting verbal and nonverbal skills, executive function, social behavior, and social anxiety.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1542\/peds.2023-065145","type":"journal-article","created":{"date-parts":[[2024,9,12]],"date-time":"2024-09-12T08:30:17Z","timestamp":1726129817000},"source":"Crossref","is-referenced-by-count":3,"title":["Cognitive and Social\u2013Emotional Development in Girls With Fragile X 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