{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T12:59:01Z","timestamp":1786539541384,"version":"build-2736575974"},"reference-count":24,"publisher":"American Academy of Pediatrics (AAP)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,12,1]]},"abstract":"<jats:sec>\n                  <jats:title>BACKGROUND<\/jats:title>\n                  <jats:p>In 2023, nirsevimab, a monoclonal antibody against respiratory syncytial virus (RSV), was approved in the United States to be given to infants to prevent bronchiolitis, a leading cause of pediatric hospitalizations. We sought to better understand how parents of otherwise healthy newborns would respond to this recommendation.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>We conducted semistructured interviews of purposefully sampled parents of newborns admitted to the well newborn unit between November 2023 and February 2024. Interviews were performed in a constant comparative manner until thematic sufficiency was reached using the Health Beliefs Model as a conceptual framework.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>We conducted 28 interviews: 38% of participants planned to give nirsevimab to their newborn, 25% did not plan to, and 38% were unsure. Four major themes emerged: (1) Major knowledge gaps existed about RSV prophylaxis; (2) trust in pediatrician\u2019s recommendation and fear of RSV infection contributed to uptake; (3) parents deferring RSV prophylaxis were concerned about side effects, wanted more time to decide, felt the maternal RSV vaccine was sufficient, and trusted their own prevention measures; and (4) there was misinformation about nirsevimab among parents including a perception that nirsevimab is a new understudied vaccine with similarities to the COVID-19 vaccine. Application of the Health Beliefs Model highlighted actionable opportunities to positively influence decision making around perceived susceptibility and RSV disease severity, benefits, barriers, self-efficacy, and cues to action.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>Increasing overall awareness of both nirsevimab and RSV in infants, starting conversations during pregnancy to combat misinformation, leveraging trusting relationships with pediatricians and prenatal clinicians can help with future uptake.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1542\/peds.2024-067532","type":"journal-article","created":{"date-parts":[[2024,11,26]],"date-time":"2024-11-26T08:09:37Z","timestamp":1732608577000},"source":"Crossref","is-referenced-by-count":16,"title":["Parent Perspectives on Nirsevimab for Their Newborn"],"prefix":"10.1542","volume":"154","author":[{"given":"Sarah","family":"Hinderstein","sequence":"first","affiliation":[{"name":"aYale School of Public Health, New Haven, Connecticut"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Aragona","sequence":"additional","affiliation":[{"name":"bDepartment of Pediatrics, Yale School of Medicine, New Haven, Connecticut"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaspreet","family":"Loyal","sequence":"additional","affiliation":[{"name":"bDepartment of Pediatrics, Yale School of Medicine, New Haven, Connecticut"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"417","published-online":{"date-parts":[[2024,11,26]]},"reference":[{"issue":"6","key":"2024121614381303800_B1","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1056\/NEJMoa0804877","article-title":"The burden of respiratory syncytial virus infection in young children","volume":"360","author":"Hall","year":"2009","journal-title":"N Engl J Med"},{"key":"2024121614381303800_B2","unstructured":"National Foundation For Infectious Diseases. Respiratory syncytial virus (RSV). Available at: https:\/\/www.nfid.org\/infectious-disease\/rsv\/. Updated January 2024. Accessed May 9, 2024"},{"issue":"4","key":"2024121614381303800_B3","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1007\/s40121-017-0167-9","article-title":"Chronologic age at hospitalization for respiratory syncytial virus among preterm and term infants in the United States","volume":"6","author":"Parikh","year":"2017","journal-title":"Infect Dis Ther"},{"issue":"34","key":"2024121614381303800_B4","doi-asserted-by":"crossref","first-page":"920","DOI":"10.15585\/mmwr.mm7234a4","article-title":"Use of nirsevimab for the prevention of respiratory syncytial virus disease among infants and young children: recommendations of the Advisory Committee on Immunization Practices - United States, 2023","volume":"72","author":"Jones","year":"2023","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"2024121614381303800_B5","article-title":"Healthcare providers: RSV prevention information","author":"Center for Disease Control and Prevention","year":"2023"},{"issue":"9","key":"2024121614381303800_B6","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1542\/hpeds.2021-005977","article-title":"Trends in and documentation of refusal of common routine newborn interventions: 2013\u20132019","volume":"11","author":"Loyal","year":"2021","journal-title":"Hosp Pediatr"},{"issue":"2","key":"2024121614381303800_B7","doi-asserted-by":"crossref","first-page":"33","DOI":"10.15585\/mmwr.mm7202a3","article-title":"Vaccination coverage by age 24 months among children born during 2018\u20132019 - National Immunization Survey-Child, United States, 2019\u20132021","volume":"72","author":"Hill","year":"2023","journal-title":"MMWR Morb Mortal Wkly Rep"},{"issue":"3","key":"2024121614381303800_B8","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1542\/hpeds.2019-0228","article-title":"Refusal of intramuscular vitamin K by parents of newborns: a review","volume":"10","author":"Loyal","year":"2020","journal-title":"Hosp Pediatr"},{"issue":"45","key":"2024121614381303800_B9","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.15585\/mmwr.mm7245a2","article-title":"Coverage with selected vaccines and exemption from school vaccine requirements among children in kindergarten - United States, 2022\u201323 school year","volume":"72","author":"Seither","year":"2023","journal-title":"MMWR Morb Mortal Wkly Rep"},{"issue":"10","key":"2024121614381303800_B10","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1080\/14760584.2022.2108799","article-title":"Parental knowledge about respiratory syncytial virus (RSV) and attitudes to infant immunization with monoclonal antibodies","volume":"21","author":"Lee Mortensen","year":"2022","journal-title":"Expert Rev Vaccines"},{"issue":"7","key":"2024121614381303800_B11","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1016\/j.acap.2019.04.003","article-title":"Refusal of vitamin K by parents of newborns: a qualitative study","volume":"19","author":"Loyal","year":"2019","journal-title":"Acad Pediatr"},{"key":"2024121614381303800_B12","unstructured":"Centers for Disease Control and Prevention. Respiratory syncytial virus infection (RSV). Available at: https:\/\/www.cdc.gov\/vaccines\/vpd\/rsv\/index.html. Accessed July 26, 2024"},{"issue":"6","key":"2024121614381303800_B13","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1093\/intqhc\/mzm042","article-title":"Consolidated criteria for reporting qualitative research (COREQ): a 32-item checklist for interviews and focus groups","volume":"19","author":"Tong","year":"2007","journal-title":"Int J Qual Health Care"},{"key":"2024121614381303800_B14","volume-title":"Chapter 2 The health belief model","author":"Conner","year":"2015","edition":"3rd ed"},{"issue":"4","key":"2024121614381303800_B15","doi-asserted-by":"crossref","first-page":"816","DOI":"10.3390\/vaccines11040816","article-title":"How well the constructs of health belief model predict vaccination intention: a systematic review on COVID-19 primary series and booster vaccines","volume":"11","author":"Limbu","year":"2023","journal-title":"Vaccines (Basel)"},{"key":"2024121614381303800_B16","unstructured":"Center for Disease Control and Prevention. Nirsevimab receipt and intent for infants, United States. Updated March 12, 2024. Available at: https:\/\/www.cdc.gov\/vaccines\/imz-managers\/coverage\/rsvvaxview\/nirsevimab-coverage.html. Accessed May 9, 2024"},{"issue":"9","key":"2024121614381303800_B17","first-page":"687","article-title":"FDA approves long-acting RSV antibody","volume":"22","author":"Mullard","year":"2023","journal-title":"Nat Rev Drug Discov"},{"issue":"10","key":"2024121614381303800_B18","doi-asserted-by":"crossref","first-page":"e20002","DOI":"10.2196\/20002","article-title":"Parental online information access and childhood vaccination decisions in North America: scoping review","volume":"22","author":"Ashfield","year":"2020","journal-title":"J Med Internet Res"},{"issue":"3","key":"2024121614381303800_B19","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1177\/1090198118819716","article-title":"Vaccine information sources and parental trust in their child's health care provider","volume":"46","author":"Eller","year":"2019","journal-title":"Health Educ Behav"},{"issue":"6","key":"2024121614381303800_B20","doi-asserted-by":"crossref","first-page":"e20171117","DOI":"10.1542\/peds.2017-1117","article-title":"Web-based social media intervention to increase vaccine acceptance: a randomized controlled trial","volume":"140","author":"Glanz","year":"2017","journal-title":"Pediatrics"},{"issue":"5","key":"2024121614381303800_B21","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1542\/peds.2005-1728","article-title":"Qualitative analysis of mothers' decision-making about vaccines for infants: the importance of trust","volume":"117","author":"Benin","year":"2006","journal-title":"Pediatrics"},{"issue":"1","key":"2024121614381303800_B22","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1007\/s10995-012-0957-3","article-title":"Reasons why women accept or reject the trivalent inactivated influenza vaccine (TIV) during pregnancy","volume":"17","author":"Meharry","year":"2013","journal-title":"Matern Child Health J"},{"key":"2024121614381303800_B23","doi-asserted-by":"crossref","first-page":"1149125","DOI":"10.3389\/fped.2023.1149125","article-title":"The influence of pediatricians\u2019 recommendation on caregivers\u2019 COVID-19 vaccine acceptance for children: a nationwide cross-sectional survey study from USA","volume":"11","author":"Mondal","year":"2023","journal-title":"Front Pediatr"},{"issue":"1","key":"2024121614381303800_B24","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/s10900-021-01017-9","article-title":"Parental perspectives on immunizations: impact of the COVID-19 pandemic on childhood vaccine hesitancy","volume":"47","author":"He","year":"2022","journal-title":"J Community Health"}],"container-title":["Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/publications.aap.org\/pediatrics\/article-pdf\/doi\/10.1542\/peds.2024-067532\/1750482\/peds.2024-067532.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/publications.aap.org\/pediatrics\/article-pdf\/doi\/10.1542\/peds.2024-067532\/1750482\/peds.2024-067532.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,16]],"date-time":"2024-12-16T14:39:19Z","timestamp":1734359959000},"score":1,"resource":{"primary":{"URL":"https:\/\/publications.aap.org\/pediatrics\/article\/154\/6\/e2024067532\/199969\/Parent-Perspectives-on-Nirsevimab-for-Their"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,26]]},"references-count":24,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2024,11,26]]},"published-print":{"date-parts":[[2024,12,1]]}},"URL":"https:\/\/doi.org\/10.1542\/peds.2024-067532","relation":{},"ISSN":["0031-4005","1098-4275"],"issn-type":[{"value":"0031-4005","type":"print"},{"value":"1098-4275","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,26]]},"article-number":"e2024067532"}}