{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:03:04Z","timestamp":1753887784193,"version":"3.41.2"},"reference-count":20,"publisher":"American Academy of Pediatrics (AAP)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,5,1]]},"abstract":"<jats:p>Encephalopathy is a disturbance in neurologic function. It is commonly attributed to infectious and inflammatory etiologies but encompasses a wide differential. Hypereosinophilic syndrome (HES) is a rare cause of encephalopathy that is associated with underlying infection or malignancy. We present a pediatric patient who experienced several days of worsening encephalopathy and neurological deterioration associated with influenza B infection and hypereosinophilia. A thorough workup ultimately revealed a diagnosis of HES secondary to B cell acute lymphoblastic leukemia (B-ALL). This case exemplifies the importance of maintaining a broad approach to the diagnostic evaluation, treatment, and management of encephalopathy.<\/jats:p>","DOI":"10.1542\/peds.2024-068064","type":"journal-article","created":{"date-parts":[[2025,4,2]],"date-time":"2025-04-02T00:05:13Z","timestamp":1743552313000},"source":"Crossref","is-referenced-by-count":0,"title":["11-Year-Old Boy With B-ALL\u2013Induced Hypereosinophilic Syndrome Presenting as Acute Encephalopathy"],"prefix":"10.1542","volume":"155","author":[{"given":"Tristan","family":"Loveday","sequence":"first","affiliation":[{"name":"1Mayo Clinic College of Medicine and Health Sciences, Jacksonville, Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cintia","family":"da Hora","sequence":"additional","affiliation":[{"name":"1Mayo Clinic College of Medicine and Health Sciences, Jacksonville, Florida"},{"name":"3Department of Child and Adolescent Neurology, Nemours Children\u2019s Health, Jacksonville, Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rudolph","family":"Wells","sequence":"additional","affiliation":[{"name":"2Division of Pediatrics, University of Florida College of Medicine, Jacksonville, Florida"},{"name":"4Department of Hematology and Oncology, Nemours Children\u2019s Health, Jacksonville, Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lauren","family":"Chorny","sequence":"additional","affiliation":[{"name":"1Mayo Clinic College of Medicine and Health Sciences, Jacksonville, Florida"},{"name":"3Department of Child and Adolescent Neurology, Nemours Children\u2019s Health, Jacksonville, Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manisha","family":"Bansal","sequence":"additional","affiliation":[{"name":"1Mayo Clinic College of Medicine and Health Sciences, Jacksonville, Florida"},{"name":"2Division of Pediatrics, University of Florida College of Medicine, Jacksonville, 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