{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T16:02:13Z","timestamp":1787500933283,"version":"build-2736575974"},"reference-count":41,"publisher":"American Academy of Pediatrics (AAP)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,10,1]]},"abstract":"<jats:sec>\n                    <jats:title\/>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>OBJECTIVE<\/jats:title>\n                    <jats:p>To investigate the characteristics and trends of exposures to medications, dietary supplements, and psychoactive substances among children aged 6 to 12\u00a0years reported to US poison centers (PCs) with a focus on exposures associated with suspected self-harm or suicidal intent.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>STUDY DESIGN<\/jats:title>\n                    <jats:p>National Poison Data System data from 2000 to 2023 were analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>There were 1\u2009541\u2009565 primary substance exposures among 6- to 12-year-old children reported to US PCs from 2000 to 2023. Most involved a single substance (90.1%), involved boys (58.2%), or occurred in a residence (95.8%). Although most exposures were associated with minimal medical consequences, 3.5% of children were medically admitted, 4.0% experienced moderate effects, and 0.3% had major effects; there were 95 reported deaths. Therapeutic errors accounted for 48.6% of exposures. Although exposures associated with suspected self-harm or suicidal intent represented 4.7% of exposures overall, they accounted for 25.8% of exposures among 12-year-old children. Exposures associated with suspected self-harm or suicidal intent were more likely to be medically admitted (risk ratio [RR], 14.32; 95% CI, 14.10\u201314.56) or experience a serious medical outcome (RR, 8.04; 95% CI, 7.91\u20138.17) than other reasons for exposure. The overall rate of exposure increased by 53.8% from 2000 to 2023, whereas the exposure rate associated with suspected self-harm or suicidal intent increased by 311.2%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>The rate of exposure to medications, dietary supplements, and psychoactive substances among children aged 6 to 12\u00a0years increased from 2000 to 2023, especially exposures associated with suspected self-harm or suicidal intent. Additional targeted research and interventions are needed to prevent substance exposures among 6- to 12-year-old children, especially exposures associated with suspected self-harm or suicidal intent among 11- to 12-year-old children.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1542\/peds.2024-069753","type":"journal-article","created":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T00:02:27Z","timestamp":1757289747000},"source":"Crossref","is-referenced-by-count":2,"title":["Poison Center Calls About Self-Harm or Suicidal Intent and Other Exposure Reasons in 6- to 12-Year-Old Children"],"prefix":"10.1542","volume":"156","author":[{"given":"Matthew J.","family":"Ruge","sequence":"first","affiliation":[{"name":"1Center for Injury Research and Policy, The Abigail Wexner Research Institute at Nationwide Children\u2019s Hospital, Columbus, Ohio"},{"name":"2Central Michigan University College of Medicine, Mount Pleasant, 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