{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T21:43:30Z","timestamp":1787867010228,"version":"build-2784847793"},"reference-count":41,"publisher":"American Academy of Pediatrics (AAP)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,9,1]]},"abstract":"<jats:p>Sickle cell disease (SCD) is a complex pathophysiology with a wide range of symptoms. More than one-third of pediatric SCD emergency department encounters are due to fever. Patients with SCD are immunocompromised because of hyposplenism. Therefore, infection is a serious concern in any febrile patient with SCD. Although bacteremia is seen in only 1.1% of febrile patients with SCD, it remains the leading cause of death globally. However, several noninfectious causes of fever can be seen in SCD, which should be considered in appropriate settings.<\/jats:p>\n                  <jats:p>We present a case of an adolescent female patient with SCD who had an unusually prolonged fever and a complicated disease course that was initially attributed to infection but failed to resolve by appropriate antibiotics. Further investigations identified noninfectious etiologies of fever in the patient.<\/jats:p>","DOI":"10.1542\/peds.2024-070158","type":"journal-article","created":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T00:02:16Z","timestamp":1755561736000},"source":"Crossref","is-referenced-by-count":1,"title":["Fever in Sickle Cell Disease: Thinking Beyond Bacteremia"],"prefix":"10.1542","volume":"156","author":[{"given":"Sweta","family":"Dubey","sequence":"first","affiliation":[{"name":"1Department of Pediatrics, SUNY Downstate Health Sciences University, Brooklyn, New York"},{"name":"2NYC Health\u2009+\u2009Hospitals\/Kings County, Brooklyn, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shubhangi","family":"Tuli","sequence":"additional","affiliation":[{"name":"1Department of Pediatrics, SUNY Downstate Health Sciences University, Brooklyn, New York"},{"name":"2NYC Health\u2009+\u2009Hospitals\/Kings County, Brooklyn, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sana","family":"Usmani","sequence":"additional","affiliation":[{"name":"2NYC Health\u2009+\u2009Hospitals\/Kings County, Brooklyn, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Gesner","sequence":"additional","affiliation":[{"name":"1Department of Pediatrics, SUNY Downstate Health Sciences University, Brooklyn, New York"},{"name":"2NYC Health\u2009+\u2009Hospitals\/Kings County, Brooklyn, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Weaver","sequence":"additional","affiliation":[{"name":"1Department of Pediatrics, SUNY Downstate Health Sciences University, Brooklyn, New York"},{"name":"2NYC Health\u2009+\u2009Hospitals\/Kings County, Brooklyn, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ratna","family":"Basak","sequence":"additional","affiliation":[{"name":"2NYC Health\u2009+\u2009Hospitals\/Kings County, Brooklyn, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"417","published-online":{"date-parts":[[2025,8,19]]},"reference":[{"key":"2026050605370049600_r1","volume-title":"Evidence-Based Management of Sickle Cell Disease","author":"Expert Panel Report","year":"2014"},{"issue":"4","key":"2026050605370049600_r2","doi-asserted-by":"crossref","first-page":"e30879","DOI":"10.1002\/pbc.30879","article-title":"Oxygen saturation thresholds in managing sickle cell disease at US children\u2019s hospitals","volume":"71","author":"Yadav","year":"2024","journal-title":"Pediatr Blood Cancer."},{"key":"2026050605370049600_r3","article-title":"Deferasirox | Memorial Sloan Kettering Cancer Center","author":"Lexidrug Editorial Advisory Panel","year":"2023"},{"key":"2026050605370049600_r4","article-title":"Glutamine | Memorial Sloan Kettering Cancer Center","author":"Lexidrug Editorial Advisory Panel","year":"2022"},{"issue":"7","key":"2026050605370049600_r5","doi-asserted-by":"crossref","first-page":"e350","DOI":"10.1016\/S2352-3026(19)30080-8","article-title":"Revised international surveillance case definition of transfusion-associated circulatory overload: a classification agreement validation study","volume":"6","author":"Wiersum-Osselton","year":"2019","journal-title":"Lancet Haematol."},{"issue":"1","key":"2026050605370049600_r6","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1378\/chest.118.1.33","article-title":"Chest radiographs in acute pulmonary embolism. 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