{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T10:24:01Z","timestamp":1793701441934,"version":"4.5.1"},"reference-count":39,"publisher":"American Academy of Pediatrics (AAP)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,9,1]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND AND OBJECTIVES<\/jats:title>\n                    <jats:p>Previous studies have reported early undernutrition and growth delay in children born with esophageal atresia (EA). Our goal was to assess their long-term nutritional status.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>We longitudinally studied 204 children born with EA (91% with tracheoesophageal fistula) from birth to 16\u00a0years. Undernutrition (Z-score for body mass index [BMI]\u2009&amp;lt;\u2009\u22122 SD), and stunting (Z-score for height for age [HFA]\u2009&amp;lt;\u2009\u22122 SD) were evaluated. Risk factors were analyzed using regression models for interval-censored data.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>The mean Z-BMI and Z-HFA were lower in children with EA than the normal population from birth to age 16\u00a0years. At 12\u00a0years, the Z-BMI had increased closer to the normal range, but the Z-HFA still differed from the normal range. The cumulative incidence of wasting was 7% (95% CI, 5\u201312) among 1-year-olds with EA and 25% (95% CI, 19\u201331) of this population were undernourished at least once between ages 1 and 16\u00a0years. Undernutrition was significantly associated with congenital heart malformation (hazard ratio [HR] 2.7 [1.5\u20135.1]), prenatal EA diagnosis (HR 2.3 [1.2\u20134.3]), and use of proton pump inhibitors (PPIs) after 1\u00a0year of age (HR 3.6 [1.1\u201311.4]). Stunting was significantly associated with genetic anomalies (HR 6.0 [2.8\u201312.8]), multiple pregnancies (HR 2.4 [1.1\u20135.6]), gastrostomy (HR 2.3 [1.3\u20133.8]), and the use of PPI after 1\u00a0year (HR 7.8 [2.4\u201326.1]).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>Despite advances in care, children with EA remain at high risk of undernutrition and stunting from birth to age 16\u00a0years. Intensification of nutritional follow-up and early intervention are needed in high-risk patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1542\/peds.2025-070663","type":"journal-article","created":{"date-parts":[[2025,8,20]],"date-time":"2025-08-20T00:02:31Z","timestamp":1755648151000},"source":"Crossref","is-referenced-by-count":5,"title":["Long-Term Nutritional Status in Children Born With Esophageal Atresia"],"prefix":"10.1542","volume":"156","author":[{"given":"Madeleine","family":"Aumar","sequence":"first","affiliation":[{"name":"1University of Lille, Inserm, Centre Hospitalier Universitaire Lille, U1286, Institute for Translational Research in Inflammation, Lille, France"},{"name":"2Centre Hospitalier Universitaire Lille, Reference Center for Congenital Oesophageal Anomalies, Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzanne","family":"Depoortere","sequence":"additional","affiliation":[{"name":"2Centre Hospitalier Universitaire 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R\u00e9sultats de l\u2019\u00e9tude Esteban et \u00e9volution depuis 2006","volume":"13","author":"Verdot","year":"2017","journal-title":"Bull Epid\u00e9miol Hebd."},{"issue":"6","key":"2026050605425359200_r28","doi-asserted-by":"crossref","first-page":"705","DOI":"10.3345\/kjp.2010.53.6.705","article-title":"An 18-year experience of tracheoesophageal fistula and esophageal atresia","volume":"53","author":"Seo","year":"2010","journal-title":"Korean J Pediatr."},{"issue":"3","key":"2026050605425359200_r29","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1097\/MPG.0000000000000961","article-title":"Insufficient body weight of adults born with esophageal atresia","volume":"62","author":"Presse","year":"2016","journal-title":"J Pediatr Gastroenterol Nutr."},{"issue":"5","key":"2026050605425359200_r30","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/S1695-4033(01)77717-X","article-title":"Mortality in patients with esophageal atresia: influence of birth weight and 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