{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T21:13:18Z","timestamp":1790629998825,"version":"4.1.0"},"reference-count":36,"publisher":"American Academy of Pediatrics (AAP)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,12,1]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND AND OBJECTIVES<\/jats:title>\n                    <jats:p>Although tall stature is commonly associated with 47,XXY\/Klinefelter syndrome (KS), detailed childhood growth patterns are not well-defined. This study aimed to develop KS-specific growth charts for stature-for-age, weight-for-age, weight-for-length (0\u201324\u00a0months), and body mass index (BMI)-for-age (2\u201318\u00a0years).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>We conducted a population-based secondary analysis using clinical data from 6 US pediatric centers. The cohort included 1279 males aged younger than 20\u00a0years with a diagnosis of KS and at least 1 outpatient measurement of height and\/or weight. Nonparametric quantile regression was used to model age-related growth trajectories.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>A median of 6 longitudinal growth data points per individual contributed to the creation of KS-specific curves. Key differences from standard reference growth charts included the following: (1) approximately 20% of boys with KS aged younger than 4\u00a0years were below the 5th percentile for height, whereas\u2009approximately\u200925% exceeded the 95th percentile by late childhood; (2) height velocity increased in midchildhood (after age 6\u00a0years), but without a distinct pubertal growth spurt; and (3) BMI distribution was broader, with approximately 10% of individuals below the 5th percentile and\u2009approximately\u200925% above the 95th percentile.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>Boys with KS demonstrate distinct and variable growth trajectories compared with the general population. These KS-specific growth charts offer a valuable clinical tool for monitoring growth, guiding anticipatory counseling, and identifying atypical development patterns.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1542\/peds.2025-072193","type":"journal-article","created":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T00:02:51Z","timestamp":1762473771000},"source":"Crossref","is-referenced-by-count":1,"title":["Reference Growth Charts for Children With 47,XXY\/Klinefelter Syndrome"],"prefix":"10.1542","volume":"156","author":[{"given":"Shanlee M.","family":"Davis","sequence":"first","affiliation":[{"name":"1eXtraOrdinarY Kids Clinic and Research Program, Children\u2019s Hospital Colorado, Aurora, Colorado"},{"name":"2Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taylor E.","family":"Marshall","sequence":"additional","affiliation":[{"name":"3Department of Pediatrics, University of California Los Angeles, Los Angeles, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karli S.","family":"Swenson","sequence":"additional","affiliation":[{"name":"1eXtraOrdinarY Kids Clinic and Research Program, Children\u2019s Hospital Colorado, Aurora, Colorado"},{"name":"2Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha","family":"Bothwell","sequence":"additional","affiliation":[{"name":"1eXtraOrdinarY Kids Clinic and Research Program, Children\u2019s Hospital Colorado, Aurora, Colorado"},{"name":"2Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie J.","family":"Nokoff","sequence":"additional","affiliation":[{"name":"2Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amelia","family":"Middleton","sequence":"additional","affiliation":[{"name":"1eXtraOrdinarY Kids Clinic and Research Program, Children\u2019s Hospital Colorado, Aurora, Colorado"},{"name":"2Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Furniss","sequence":"additional","affiliation":[{"name":"4University of Colorado Adult and Child Consortium for Health Outcomes Research & Delivery Sciences (ACCORDS), Aurora, Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maram","family":"Alkhdour","sequence":"additional","affiliation":[{"name":"5Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitri 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Pediatrics, Nemours Children\u2019s Health Delaware, Wilmington, Delaware"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen I.","family":"Stone","sequence":"additional","affiliation":[{"name":"5Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria G.","family":"Vogiatzi","sequence":"additional","affiliation":[{"name":"9Department of Pediatrics, Division of Endocrinology, Children\u2019s Hospital of Philadelphia, Philadelphia, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole R.","family":"Tartaglia","sequence":"additional","affiliation":[{"name":"1eXtraOrdinarY Kids Clinic and Research Program, Children\u2019s Hospital Colorado, Aurora, Colorado"},{"name":"2Department of Pediatrics, University of Colorado School of Medicine, Aurora, 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