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According to a 2001 consensus paper from the American Academy of Pain Medicine, American Pain Society, and American Society of Addiction Medicine, dependence is defined as \u201ca state of adaptation that is manifested by a drug class specific withdrawal syndrome that can be produced by abrupt cessation, rapid dose reduction, decreasing blood level of the drug, or administration of an antagonist.\u201d The experience of children undergoing iatrogenic withdrawal symptoms is variable and may be mild and go unreported or can be severe and even life threatening. Guidance on opioid withdrawal is available only for adults and primarily for adults with substance use disorders. This report will summarize existing literature and provide readers with information on how to screen for symptoms of iatrogenic opioid withdrawal as well as mechanisms for opioid withdrawal prevention.<\/jats:p>","DOI":"10.1542\/peds.2025-073169","type":"journal-article","created":{"date-parts":[[2025,8,18]],"date-time":"2025-08-18T00:02:23Z","timestamp":1755475343000},"source":"Crossref","is-referenced-by-count":1,"title":["Recognition and Management of Iatrogenically Induced Opioid Dependence and Withdrawal in Children: Clinical Report"],"prefix":"10.1542","volume":"156","author":[{"given":"Adam C.","family":"Adler","sequence":"first","affiliation":[{"name":"1Department of Anesthesiology, Perioperative and Pain Medicine, Texas Children\u2019s Hospital, Baylor College of Medicine, Houston, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda B.","family":"Siegel","sequence":"additional","affiliation":[{"name":"2Northwell, New Hyde Park, New York; Department of Pediatrics, Division of Critical Care, Zucker School of Medicine, Cohen Children\u2019s Medical Center, Queens, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert T.","family":"Wilder","sequence":"additional","affiliation":[{"name":"3Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Good","sequence":"additional","affiliation":[{"name":"4Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford Medicine Children\u2019s Health, Stanford, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Committee on Drugs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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