{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T08:38:41Z","timestamp":1792658321019,"version":"4.5.0"},"reference-count":29,"publisher":"American Academy of Pediatrics (AAP)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,7,1]]},"abstract":"<jats:sec>\n                    <jats:title\/>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>OBJECTIVE<\/jats:title>\n                    <jats:p>Few studies have described long-term respiratory sequelae of adolescent (people aged 10\u201319\u00a0years) tuberculosis (TB) survivors. We hypothesized that compared with healthy adolescents with no history of TB, survivors of adolescent pulmonary TB have greater respiratory impairment (reduced lung function) and disability (symptoms and activity limitations).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>In this prospective cohort study in Lima, Peru, we used spirometry, oscillometry, and the St George\u2019s Respiratory Questionnaire (SGRQ) to evaluate, on 2 separate occasions, the lung health of adolescents successfully treated for pulmonary TB and matched healthy controls. TB survivors with abnormal lung function underwent chest computed tomography (CT). Using mixed-effects regression with an interaction term for time since treatment completion and random effects for individual and matched pairs, we modeled changes in lung function and disability over 24\u00a0months from treatment completion, comparing findings between TB survivors and controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Compared with 101 controls (median age 17\u00a0years, 56% male), 101 TB survivors (median age 18\u00a0years, 56% male) had less favorable forced expiratory volume in 1 second, forced vital capacity, total airway resistance (R5), small airway resistance (R5-20), and reactance area (AX). Over the study period, AX, R5, and R5-20 improved for TB survivors but remained worse than controls. TB survivors had persistently greater respiratory disability (measured by SGRQ). Chest CTs of TB survivors demonstrated architectural distortion, reticular patterns, nodules, and bronchiectasis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>Adolescent TB survivors experience persistent, symptomatic chronic lung disease despite bacteriological cure. Our findings highlight the need for respiratory assessments beyond treatment completion.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1542\/peds.2025-074970","type":"journal-article","created":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T00:02:57Z","timestamp":1782172977000},"source":"Crossref","is-referenced-by-count":1,"title":["Posttuberculosis Lung Disease in Adolescents in Lima, Peru"],"prefix":"10.1542","volume":"158","author":[{"given":"Silvia S.","family":"Chiang","sequence":"first","affiliation":[{"name":"1Department of Pediatrics, Warren Alpert Medical School, Brown University, Providence, Rhode Island"},{"name":"2Center for International Health Research, Brown University Health, Providence, Rhode Island"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Savvas","family":"Andronikou","sequence":"additional","affiliation":[{"name":"3Department of Radiology, Children\u2019s Hospital of Philadelphia, Philadelphia, Pennsylvania"},{"name":"4Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Betsabe","family":"Roman Sinche","sequence":"additional","affiliation":[{"name":"5Socios En Salud Sucursal Per\u00fa, Lima, Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Furman","sequence":"additional","affiliation":[{"name":"6Department of Radiology, Warren Alpert Medical School, Brown University, Providence, Rhode Island"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. Simon","family":"Schaaf","sequence":"additional","affiliation":[{"name":"7Desmond Tutu TB Centre, Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clemax C.","family":"Sant\u2019Anna","sequence":"additional","affiliation":[{"name":"8Departamento de Pediatria, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hansel J.","family":"Otero","sequence":"additional","affiliation":[{"name":"3Department of Radiology, Children\u2019s Hospital of Philadelphia, Philadelphia, Pennsylvania"},{"name":"4Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua Ray","family":"Tanzer","sequence":"additional","affiliation":[{"name":"1Department of Pediatrics, Warren Alpert Medical School, Brown University, Providence, Rhode Island"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonid","family":"Lecca","sequence":"additional","affiliation":[{"name":"5Socios En Salud Sucursal Per\u00fa, Lima, Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony L.","family":"Byrne","sequence":"additional","affiliation":[{"name":"9Faculty of Medicine, St Vincent\u2019s Clinical School, University of New South Wales, Sydney, New South Wales, Australia"},{"name":"10Department of Thoracic Medicine, Heart Lung Stream, St Vincent\u2019s Hospital, Sydney, New South Wales, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"417","published-online":{"date-parts":[[2026,6,23]]},"reference":[{"issue":"3","key":"2026102203471010400_r1","doi-asserted-by":"crossref","first-page":"e015368","DOI":"10.1136\/bmjgh-2024-015368","article-title":"Factors driving adolescent tuberculosis incidence by age and sex in 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