{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T12:02:09Z","timestamp":1791201729685,"version":"4.2.0"},"reference-count":16,"publisher":"American Academy of Pediatrics (AAP)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10,1]]},"abstract":"<jats:p>To report the successful use of continuous renal replacement therapy (CRRT) in a child with type 1 diabetes mellitus (T1DM) and intravenous immunoglobulin (IVIG)\u2013refractory Kawasaki disease shock syndrome (KDSS). A 3-year, 10-month-old boy with poorly controlled T1DM and autoimmune thyroiditis presented with KDSS and diabetic ketoacidosis. Despite IVIG and high-dose aspirin, he developed refractory shock and metabolic acidosis. Continuous venovenous hemodiafiltration was initiated, leading to rapid hemodynamic stabilization, resolution of hyperinflammation, and metabolic normalization. CRRT may serve as a rescue therapy in critically ill children with concurrent cytokine storm and metabolic crisis, particularly when standard immunomodulatory therapies fail.<\/jats:p>","DOI":"10.1542\/peds.2025-075282","type":"journal-article","created":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T00:03:05Z","timestamp":1788307385000},"source":"Crossref","is-referenced-by-count":0,"title":["Continuous Renal Replacement Therapy for Cytokine Storm in Diabetic Kawasaki Shock Syndrome"],"prefix":"10.1542","volume":"158","author":[{"given":"Zhijiang","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Emergency and Pediatric Critical Care Medicine, Guiyang Maternal and Child Health Care Hospital, Guiyang, Guizhou Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Ling","sequence":"additional","affiliation":[{"name":"Department of Emergency and Pediatric Critical Care Medicine, Guiyang Maternal and Child Health Care Hospital, Guiyang, Guizhou Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Emergency and Pediatric Critical Care Medicine, Guiyang Maternal and Child Health Care Hospital, Guiyang, Guizhou Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Emergency and Pediatric Critical Care Medicine, Guiyang Maternal and Child Health Care Hospital, Guiyang, Guizhou Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Emergency and Pediatric Critical Care Medicine, Guiyang Maternal and Child Health Care Hospital, Guiyang, Guizhou Province, 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