{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T12:52:55Z","timestamp":1791204775388,"version":"4.2.0"},"reference-count":37,"publisher":"American Academy of Pediatrics (AAP)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10,1]]},"abstract":"<jats:sec>\n                    <jats:title\/>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>BACKGROUND AND OBJECTIVE<\/jats:title>\n                    <jats:p>Consensus guidelines have recommended eye examinations for all newborns with congenital cytomegalovirus (cCMV) infection; however, structured ophthalmic examinations are seldom reported. Existing literature suggests ocular pathology is uncommon in cCMV, particularly asymptomatic cCMV. We aimed to assess utility of ophthalmology examination in every infant with cCMV identified on newborn screening and whether alternative, risk-based strategies should be considered.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DESIGN<\/jats:title>\n                    <jats:p>Eye examination records were reviewed for infants who screened positive for cCMV from routinely collected newborn dried blood spot between July 2019 and January 2022 in Ontario, Canada. Prevalence of cCMV-related ophthalmic findings in infants with symptomatic and asymptomatic cCMV infection was evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Of 394 infants who screened positive for cCMV, 347 (88.1%) had eye examinations; of these, 51 (14.7%) had symptomatic cCMV. Two infants with symptomatic cCMV had unilateral chorioretinal scars attributable to cCMV, constituting 0.58% of CMV-positive infants and 3.9% of infants with symptomatic cCMV. Both infants were referred to ophthalmology with clinically diagnosed cCMV with significant systemic manifestations, before their CMV screening results were known. No infant with asymptomatic infection had CMV-related ocular findings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>Eye abnormalities attributable to cCMV were rarely identified through this large, population-based screening program and were not found in infants with asymptomatic cCMV. This suggests eye examination for every newborn with cCMV detected on screening is not routinely indicated. Alternative criteria for ophthalmology referral may be considered, such as infants with symptomatic cCMV and those with coexisting features their physician deems relevant.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1542\/peds.2025-075586","type":"journal-article","created":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T00:03:01Z","timestamp":1789948981000},"source":"Crossref","is-referenced-by-count":1,"title":["Eye Findings Following Congenital Cytomegalovirus Newborn Screening"],"prefix":"10.1542","volume":"158","author":[{"given":"Kate E.","family":"Leahy","sequence":"first","affiliation":[{"name":"1Department of Ophthalmology and Vision Sciences, The Hospital for Sick Children, Toronto, Ontario, Canada"},{"name":"2Department of Ophthalmology and Vision Sciences, University of Toronto, Toronto, Ontario, Canada"},{"name":"3Department of Ophthalmology, Queensland Children\u2019s Hospital, Brisbane, Queensland, Australia"},{"name":"4Save Sight Institute, University of Sydney, Sydney, New South Wales, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica K. E.","family":"Dunn","sequence":"additional","affiliation":[{"name":"5Department of Pediatrics, Alberta Children\u2019s Hospital, University of Calgary, Calgary, Alberta, Canada"},{"name":"6Newborn Screening Ontario, Children\u2019s Hospital of Eastern Ontario, Ottawa, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren","family":"Gallagher","sequence":"additional","affiliation":[{"name":"6Newborn Screening Ontario, Children\u2019s Hospital of Eastern Ontario, Ottawa, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"Reuvers","sequence":"additional","affiliation":[{"name":"6Newborn Screening Ontario, Children\u2019s Hospital of Eastern Ontario, Ottawa, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pranesh","family":"Chakraborty","sequence":"additional","affiliation":[{"name":"6Newborn Screening Ontario, Children\u2019s Hospital of Eastern Ontario, Ottawa, Ontario, Canada"},{"name":"7Department of Pediatrics, Children\u2019s Hospital of Eastern Ontario, University of Ottawa, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ari","family":"Bitnun","sequence":"additional","affiliation":[{"name":"8Department of Pediatrics, Hospital for Sick Children, University of Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Barton","sequence":"additional","affiliation":[{"name":"9Department Pediatrics, Western University, London, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirk","family":"Leifso","sequence":"additional","affiliation":[{"name":"10Department of Pediatrics, Queen\u2019s University, Kingston, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey M.","family":"Pernica","sequence":"additional","affiliation":[{"name":"11Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason","family":"Brophy","sequence":"additional","affiliation":[{"name":"7Department of Pediatrics, Children\u2019s Hospital of Eastern Ontario, University of Ottawa, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"O\u2019Connor","sequence":"additional","affiliation":[{"name":"12Department of Ophthalmology, Children\u2019s Hospital of Eastern Ontario, University of Ottawa, Ottawa, Ontario, Canada"},{"name":"13Department of Ophthalmology, University of Ottawa, Ottawa, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inas","family":"Makar","sequence":"additional","affiliation":[{"name":"14Department of Ophthalmology, Western University, London, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sapna","family":"Sharan","sequence":"additional","affiliation":[{"name":"14Department of Ophthalmology, Western University, London, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiannis","family":"Iordanous","sequence":"additional","affiliation":[{"name":"14Department of Ophthalmology, Western University, London, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annick","family":"Fournier","sequence":"additional","affiliation":[{"name":"12Department of Ophthalmology, Children\u2019s Hospital of Eastern Ontario, University of Ottawa, Ottawa, Ontario, Canada"},{"name":"13Department of Ophthalmology, University of Ottawa, Ottawa, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kourosh","family":"Sabri","sequence":"additional","affiliation":[{"name":"15Department of Ophthalmology, McMaster University, Hamilton, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Solin","family":"Saleh","sequence":"additional","affiliation":[{"name":"12Department of Ophthalmology, Children\u2019s Hospital of Eastern Ontario, University of Ottawa, Ottawa, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi Ning J.","family":"Strube","sequence":"additional","affiliation":[{"name":"10Department of Pediatrics, Queen\u2019s University, Kingston, Ontario, Canada"},{"name":"16Department of Ophthalmology, Queen\u2019s University, Kingston, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asim","family":"Ali","sequence":"additional","affiliation":[{"name":"1Department of Ophthalmology and Vision Sciences, The Hospital for Sick Children, Toronto, Ontario, Canada"},{"name":"2Department of Ophthalmology and Vision Sciences, University of Toronto, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamiar","family":"Mireskandari","sequence":"additional","affiliation":[{"name":"1Department of Ophthalmology and Vision Sciences, The Hospital for Sick Children, Toronto, Ontario, 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