{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T13:45:00Z","timestamp":1792071900605,"version":"4.4.0"},"reference-count":45,"publisher":"American Academy of Pediatrics (AAP)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,6,1]]},"abstract":"<jats:sec>\n                    <jats:title>OBJECTIVES<\/jats:title>\n                    <jats:p>Hypothermia is a risk factor for poor outcomes in infants and children with sepsis or trauma, but its overall association with mortality among all children in the emergency department (ED) is unknown. We investigated the association between hypothermia and in-hospital mortality among children presenting to the ED.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>We performed a retrospective multicenter cohort study of pediatric (&amp;lt;18\u00a0years) ED encounters using the 2012\u20132021 Pediatric Emergency Care Applied Research Network registry. We evaluated the association between first-recorded temperature (as hypothermia [\u226436 \u00b0C], euthermia, or fever [\u226538 \u00b0C]) and in-hospital mortality in multivariable logistic regression models adjusted for demographics, vital signs, trauma, and medical complexity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Among 5\u2009308\u2009892 encounters (median age 4.92\u00a0years, IQR 1.68\u201310.7; 52.5% male), hypothermia and fever were present in 161\u2009111 (3.0%) and 715\u2009366 (13.5%), respectively. In-hospital mortality occurred in 1918 (0.04%) encounters (39.2% hypothermic, 13.3% febrile). Hypothermia at presentation was associated with in-hospital mortality overall (odds ratio [OR] 20.15, 95% CI 18.00\u201322.55). This association was present in all subgroup analyses, with greater effects in patients without medical complexity (OR 104.40, 95% CI 84.40\u2013129.14) compared with those with medical complexity (OR 8.81, 95% CI 7.68\u201310.11), and similar effects among patients with trauma (OR 25.33, 95% CI 15.82\u201340.53) and without trauma (OR 19.53, 95% CI 17.36\u201321.98).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>Hypothermia is an independent risk factor for mortality among children presenting to the ED, overall and within subgroups. Hypothermia may be an important measure to identify children at highest risk of poor outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1542\/peds.2025-075725","type":"journal-article","created":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T00:03:03Z","timestamp":1779235383000},"source":"Crossref","is-referenced-by-count":0,"title":["Hypothermia and Mortality Among Children in the Emergency Department"],"prefix":"10.1542","volume":"157","author":[{"given":"Lucy","family":"Campbell","sequence":"first","affiliation":[{"name":"1Northwestern University Feinberg School of Medicine, Chicago, Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aarthi","family":"Kottapalli","sequence":"additional","affiliation":[{"name":"1Northwestern University Feinberg School of Medicine, Chicago, Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leslie","family":"Hueschen","sequence":"additional","affiliation":[{"name":"2Department of Pediatrics, Division of Emergency Medicine, University of Missouri-Kansas City School of Medicine; Children\u2019s Mercy Hospital, Kansas City, Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan R.","family":"Higgins","sequence":"additional","affiliation":[{"name":"3Department of Pediatrics, Section of Emergency Medicine, University of Colorado Anschutz School of Medicine, Aurora, Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin J.","family":"Meyer","sequence":"additional","affiliation":[{"name":"4Department of Pediatrics, UMass Chan Medical School and UMass Memorial Children\u2019s Medical Center, Worcester, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura F.","family":"Sartori","sequence":"additional","affiliation":[{"name":"5Department of Pediatrics, Division of Emergency Medicine, Children\u2019s Hospital of Philadelphia, Philadelphia, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paria M.","family":"Wilson","sequence":"additional","affiliation":[{"name":"6Division of Emergency Medicine, Cincinnati Children\u2019s Hospital Medical Center, Cincinnati, Ohio"},{"name":"7Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naghma S.","family":"Khan","sequence":"additional","affiliation":[{"name":"8Department of Pediatrics, Division of Emergency Medicine, Emory University School of Medicine, Children\u2019s Healthcare of Atlanta, Atlanta, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Rogers","sequence":"additional","affiliation":[{"name":"9Departments of Emergency Medicine and Pediatrics, University of Michigan, Ann Arbor, Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sriram","family":"Ramgopal","sequence":"additional","affiliation":[{"name":"10Division of Emergency Medicine, Ann & Robert H. Lurie Children\u2019s Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago, Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"417","published-online":{"date-parts":[[2026,5,20]]},"reference":[{"issue":"5","key":"2026101508513503900_r1","doi-asserted-by":"crossref","first-page":"e20182459","DOI":"10.1542\/peds.2018-2459","article-title":"Pediatric readiness in the emergency department","volume":"142","author":"Remick","year":"2018","journal-title":"Pediatrics."},{"issue":"5","key":"2026101508513503900_r2","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1097\/01.ta.0000188647.03665.fd","article-title":"Is hypothermia simply a marker of shock and injury severity or an independent risk factor for mortality in trauma patients? 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Pediatr."},{"issue":"11","key":"2026101508513503900_r42","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1136\/emermed-2021-211753","article-title":"Questions persist on the emergency department management of hypothermic young infants","volume":"39","author":"Ramgopal","year":"2022","journal-title":"Emerg Med J."},{"key":"2026101508513503900_r43","doi-asserted-by":"crossref","first-page":"e66722","DOI":"10.2196\/66722","article-title":"Risk factors for serious bacterial infections among young infants with hypothermia: protocol for a multicenter, retrospective case-control study","volume":"14","author":"Ramgopal","year":"2025","journal-title":"JMIR Res Protoc."},{"key":"2026101508513503900_r44","doi-asserted-by":"crossref","first-page":"113407","DOI":"10.1016\/j.jpeds.2023.113407","article-title":"Prevalence of invasive bacterial infection in hypothermic young infants: a multisite study","volume":"258","author":"Raffaele","year":"2023","journal-title":"J 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