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When parents (or other appropriate surrogate decision makers) desire treatments for their child that are not medically recommended, these \u201cpotentially nonbeneficial\u201d interventions must be systematically considered in the context of contemporary ethical principles and relevant laws and regulations while keeping in mind the historical and cultural underpinnings that might be playing a role, the potential for racial bias and socioeconomic disparities, the role of spirituality and values in consideration of quality-of-life determinations and end-of-life care, and the nuance of probabilistic uncertainty. This technical report accompanies a clinical report of the same name and offers a stepwise approach for responding to parental requests for potentially nonbeneficial treatment to support pediatricians and other physicians in engaging and supporting patients, their families, and care teams in navigating these disagreements.<\/jats:p>","DOI":"10.1542\/peds.2026-076119","type":"journal-article","created":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T00:02:30Z","timestamp":1774224150000},"source":"Crossref","is-referenced-by-count":2,"title":["Responding to Parental Requests for Potentially Nonbeneficial Treatment in Life-Threatening Situations: Technical Report"],"prefix":"10.1542","volume":"157","author":[{"given":"Deena R.","family":"Levine","sequence":"first","affiliation":[{"name":"1Division of Quality of Life and Palliative Care, Department of Oncology, St. Jude Children\u2019s Research Hospital, Memphis, Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naomi T.","family":"Laventhal","sequence":"additional","affiliation":[{"name":"2Department of Pediatrics, Division of Neonatal Medicine, Center for Bioethics and Social Sciences in Medicine, University of Michigan, Ann Arbor, Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Macauley","sequence":"additional","affiliation":[{"name":"3Division of Palliative Care, Department of Pediatrics, Oregon Health & Science University, Portland, Oregon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Committee on Bioethics","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Macauley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ratna","family":"Basak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gina Marie","family":"Geis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naomi Tricot","family":"Laventhal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas J.","family":"Opel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"417","published-online":{"date-parts":[[2026,3,23]]},"reference":[{"issue":"4","key":"2026071613015663100_r1","doi-asserted-by":"crossref","first-page":"e2026076118","DOI":"10.1542\/peds.2026-076118","article-title":"Responding to parental requests for potentially nonbeneficial treatment in life-threatening situations: technical report","volume":"157","author":"Levine","year":"2026","journal-title":"Pediatrics."},{"issue":"3","key":"2026071613015663100_r2","doi-asserted-by":"crossref","first-page":"e20171961","DOI":"10.1542\/peds.2017-1961","article-title":"Pediatric integrative medicine","volume":"140","author":"McClafferty","year":"2017","journal-title":"Pediatrics."},{"key":"2026071613015663100_r3","article-title":"Choosing Wisely Campaign Toolkit","author":"American Academy of Pediatrics"},{"key":"2026071613015663100_r4","volume-title":"Methods in Medical Ethics","author":"Sugarman","year":"2010","edition":"2nd ed"},{"key":"2026071613015663100_r5","doi-asserted-by":"crossref","DOI":"10.1093\/oso\/9780195082890.001.0001","volume-title":"The Virtues in Medical Practice","author":"Pellegrino","year":"1993"},{"key":"2026071613015663100_r6","volume-title":"In a Different Voice: Psychological Theory and Women\u2019s Development","author":"Gilligan","year":"2003"},{"issue":"4","key":"2026071613015663100_r7","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1007\/BF00489890","article-title":"Casuistry as methodology in clinical ethics","volume":"12","author":"Jonsen","year":"1991","journal-title":"Theor Med."},{"key":"2026071613015663100_r8","volume-title":"Principles of biomedical ethics","author":"Beauchamp","year":"2009","edition":"6th ed"},{"issue":"3","key":"2026071613015663100_r9","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1378\/chest.10-2532","article-title":"A brief historical and theoretical perspective on patient autonomy and medical decision making: Part I: The beneficence model","volume":"139","author":"Will","year":"2011","journal-title":"Chest."},{"key":"2026071613015663100_r10","volume-title":"Hippocrates II","author":"Hippocrates","year":"1923"},{"key":"2026071613015663100_r11","volume-title":"Schloendoerff v. 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