{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T12:53:00Z","timestamp":1791204780941,"version":"4.2.0"},"reference-count":126,"publisher":"American Academy of Pediatrics (AAP)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10,1]]},"abstract":"<jats:p>Sydenham chorea (SC) has been conventionally recognized as a movement disorder that occurs in 10%\u201350% of pediatric patients with acute rheumatic fever. In this article, we review the research on SC\u2019s psychiatric aspects and detail how physicians writing in English have grappled with questions of SC\u2019s psychological and somatic etiology and symptoms over the past 150 years. We demonstrate that the current neuropsychiatric understanding of SC in Anglophone contexts is the result of decades of scientific dialogue, with its mental, emotional, and behavioral symptoms now identified as a feature of organic pathology. This examination provides a valuable perspective on the challenges of interpreting and understanding the central nervous system manifestations of autoimmune illness caused by Group A Streptococcus.<\/jats:p>","DOI":"10.1542\/peds.2026-076410","type":"journal-article","created":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:02:10Z","timestamp":1789516930000},"source":"Crossref","is-referenced-by-count":0,"title":["Perspectives on Psychiatric Features of Sydenham Chorea"],"prefix":"10.1542","volume":"158","author":[{"given":"Lisa","family":"Mendelman","sequence":"first","affiliation":[{"name":"1Division of Allergy, Immunology, and Rheumatology, Department of Pediatrics, Stanford University School of Medicine, Palo Alto, California"},{"name":"2Stanford Immune Behavioral Health Clinic and Research Program, Stanford University School of Medicine, Stanford Children\u2019s Health\/Lucile Packard Children\u2019s Hospital, Palo Alto, California"},{"name":"3Menlo College, Atherton, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Russell C.","family":"Dale","sequence":"additional","affiliation":[{"name":"4Kids Neuroscience Centre, Children\u2019s Hospital at Westmead Clinical School, University of Sydney, Sydney, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine","family":"Mackenzie","sequence":"additional","affiliation":[{"name":"5Division of Child Neurology, Department of Neurology, Stanford University and Stanford Children\u2019s Health\/Lucile Packard Children\u2019s Hospital, Palo Alto, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Michael","family":"Bostwick","sequence":"additional","affiliation":[{"name":"6Department of Psychiatry, Mayo Clinic, Rochester, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen R.","family":"Wald","sequence":"additional","affiliation":[{"name":"7Division of Infectious Disease, Department of Pediatrics, University of Wisconsin, Madison, Madison, Wisconsin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terence","family":"Sanger","sequence":"additional","affiliation":[{"name":"8Department of Neurology, Rady Children\u2019s Health Orange County and University of California, Irvine, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kate","family":"Miles","sequence":"additional","affiliation":[{"name":"1Division of Allergy, Immunology, and Rheumatology, Department of Pediatrics, Stanford University School of Medicine, Palo Alto, California"},{"name":"2Stanford Immune Behavioral Health Clinic and Research Program, 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